A5066854663- Protein Tyrosine Phosphatases
- Influenza Virus Research Studies
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- Nuclear Receptors and Signaling
- ATP Synthase and ATPases Research
- RNA Research and Splicing
- RNA modifications and cancer
- Respiratory viral infections research
- Olfactory and Sensory Function Studies
- Fetal and Pediatric Neurological Disorders
- Microtubule and mitosis dynamics
- Neurogenesis and neuroplasticity mechanisms
- Biochemical Analysis and Sensing Techniques
- Cerebrospinal fluid and hydrocephalus
- Animal Disease Management and Epidemiology
- Endoplasmic Reticulum Stress and Disease
- Diet and metabolism studies
- Genetic and Kidney Cyst Diseases
- DNA Repair Mechanisms
- Photochromic and Fluorescence Chemistry
- Metabolism and Genetic Disorders
- Viral Infections and Vectors
- interferon and immune responses
Kunming Institute of Zoology
2017-2024
Chinese Academy of Sciences
2016-2024
University of Chinese Academy of Sciences
2017-2022
Peking University
2021
University of North Carolina at Chapel Hill
2021
National Institutes for Food and Drug Control
2021
Chinese Institute for Brain Research
2021
Wuhan Institute of Virology
2016-2018
Long noncoding RNAs (lncRNAs) mediate important epigenetic regulation in a wide range of biological processes and diseases. We applied comprehensive analyses RNA-seq CAGE-seq (cap analysis gene expression sequencing) to characterize the dynamic changes lncRNA rhesus macaque ( Macaca mulatta ) brain four representative age groups. identified 18 anatomically diverse modules 14 mRNA representing spatial, age, sex specificities. Spatiotemporal- sex-biased were generally higher than those...
Abstract Cross‐protective and non‐invasively administered vaccines are attractive highly desired for the control of influenza. Self‐assembling nanotechnology provides an opportunity development with superior performance. In this study, intranasal nanovaccine is developed targeting conserved ectodomain influenza matrix protein 2(M2e). 3‐sequential repeats M2e (3M2e) presented on self‐assembling recombinant human heavy chain ferritin (rHF) cage to form 3M2e‐rHF nanoparticle. Intranasal...
Abstract In May 2014, China formally confirmed the first human infection with novel H5N6 avian influenza virus (AIV) in Sichuan Province. Before case was reported, surveillance of AIVs wild birds resulted detection three viruses faecal samples from migratory waterfowl Chenhu wetlands, Hubei Province, China. Genetic and phylogenetic analyses revealed that these were closely related to has caused infections since 2014. A Bayesian reconstruction all eight segments suggests multiple reassortment...
Endogenous DNA double-strand breaks (DSBs) formation and repair in neural stem/progenitor cells (NSPCs) play fundamental roles neurogenesis neurodevelopmental disorders. NSPCs exhibit heterogeneity terms of lineage fates activity. Whether also have heterogeneous regulations on DSB to accommodate region-specific has not been explored. Here, we identified a regional regulator Filia, which is predominantly expressed mouse hippocampal after birth regulates repair. On one hand, Filia protects...
Abstract Maintaining mitochondrial homeostasis is crucial for cell survival and organismal health, as evidenced by the links between dysfunction various diseases, including Alzheimer’s disease (AD). Here, we report that lncMtDloop , a non-coding RNA of unknown function encoded within D-loop region genome, maintains levels with age. expression decreased in brains both human AD patients 3xTg mouse models. Furthermore, binds to transcription factor A (TFAM), facilitates TFAM recruitment mtDNA...
In article number 1703207, Jianjun Chen, Zongqiang Cui, and co-workers develop an intranasal nanovaccine which provides protection against homo- heterosubtypic influenza. The 3M 2e-rHF is constructed by displaying three-sequential repeats of the influenza conserved antigen M2e on self-assembling recombinant human heavy chain ferritin (rHF) cage. Intranasal vaccination with 3M2e-rHF in absence adjuvants confers complete a lethal infection homosubtypic H1N1 H9N2 virus.
Abstract PTPRT (receptor‐type tyrosine‐protein phosphatase T), a brain‐specific type 1 transmembrane protein, plays an important role in neurodevelopment and synapse formation. However, whether abnormal signaling is associated with Alzheimer's disease (AD) remains elusive. Here, we report that Ptprt mRNA expression found to be downregulated the brains of both human mouse models AD. We further identified intracellular domain (PICD), which released by ADAM10‐ γ‐secretase‐dependent cleavage...
Abstract Maintaining mitochondrial homeostasis stands as a critical factor for cell survival and the health of organisms, evidenced by links between dysfunction spectrum diseases, including Alzheimer’s disease (AD). Here we report that lncMtDloop , lncRNA originating from mtDNA D-loop, upholds homeostasis. LncMtDloop demonstrates an affinity transcription A (TFAM), thereby facilitating TFAM’s recruitment to promoters enhancing gene transcription. We further observed decreased expression in...
Abstract Loss of mitochondrial homeostasis are evident in Alzheimer's disease (AD) 1 . However, the underlying mechanisms remain largely elusive. In this study, we report that lncMtDloop , an age-related and conserved long noncoding RNA derived from DNA (mtDNA) D-loop, is crucial for sustaining transcription homeostasis, associates with Alzheimer’s pathogenesis. Notably, level expression diminished brains human AD patients 3xTg mouse model, whereas failure to recruit factor A (TFAM) leads...
Abstract Background PTPRT (receptor-type tyrosine-protein phosphatase T), as a brain-specific type 1 transmembrane protein, plays an important function in neurodevelopment and synapse formation. However, whether PTPRT-dependent signaling is involved Alzheimer’s disease (AD) remains elusive. Methods We have begun to address these questions by investigation of the relationship between Ab both postmortem human AD brain tissues, APP/PS1 mice, different cell lines using biochemical histological...
Abstract BackgroundPTPRT (receptor-type tyrosine-protein phosphatase T), as a brain-specific type 1 transmembrane protein, plays an important function in neurodevelopment and synapse formation. However, whether PTPRT-dependent signaling is involved Alzheimer’s disease (AD) remains elusive.MethodsHere, we first applied biochemistry methods bioinformatic analysis to test quantify the processing expression of PTPRT both human mouse models. AAV delivery, primary culture system,...
Abstract PTPRT (receptor-type tyrosine-protein phosphatase T), as a brain-specific type 1 transmembrane protein, plays an important function in neurodevelopment and synapse formation. However, whether PTPRT-dependent signaling is involved Alzheimer’s disease (AD) remains elusive. Here, we identified that intracellular domain (PICD), which was released from ADAM10- presenilin 1-/γ-secretase-dependent cleavage of PTPRT, efficiently translocated to the nucleus via conserved nuclear localization...