A5055354451- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Chromosomal and Genetic Variations
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Protist diversity and phylogeny
- CRISPR and Genetic Engineering
- DNA Repair Mechanisms
- Microtubule and mitosis dynamics
- Ion channel regulation and function
- RNA regulation and disease
- Pain Mechanisms and Treatments
- Telomeres, Telomerase, and Senescence
- Synthesis and biological activity
- Ferroptosis and cancer prognosis
- Sirtuins and Resveratrol in Medicine
- Traditional Chinese Medicine Studies
- Cancer, Hypoxia, and Metabolism
- Marine Bivalve and Aquaculture Studies
- Cancer, Lipids, and Metabolism
- Biological Activity of Diterpenoids and Biflavonoids
- Cellular Mechanics and Interactions
University of Science and Technology of China
2016-2025
Hefei National Center for Physical Sciences at Nanoscale
2016-2023
Shaanxi Provincial People's Hospital
2022
Shanxi Medical University
2022
Anhui Provincial Hospital
2022
Linyi University
2022
Jiangxi Agricultural University
2018-2020
Center for Excellence in Molecular Cell Science
2016-2018
Howard Hughes Medical Institute
2008-2015
University of California, San Diego
2011-2015
The Cd 2+ -inducible metallothionein ( MTT1 ) gene was cloned from Tetrahymena thermophila . Northern blot analysis showed that mRNA is not detectable in the absence of , induced within 10 min its addition, expressed proportion to concentration, and rapidly disappears upon withdrawal. Similarly, when neo1 coding region flanked by noncoding sequences used disrupt locus, no transformants were observed number proportional increased concentration. neo3 cassette, which promoter replaced histone...
Abstract Cancer stem cells (CSCs), a minor subpopulation of tumor bulks with self-renewal and seeding capacity to generate new tumors, posit significant challenge develop effective long-lasting anti-cancer therapies. The emergence drug resistance appears upon failure chemo-/radiation therapy eradicate the CSCs, thereby leading CSC-mediated clinical relapse. Accumulating evidence suggests that transcription factor SOX2, master regulator embryonic induced pluripotent cells, drives cancer...
Chronic pain causes both physical suffering and comorbid mental symptoms such as anhedonia. However, the neural circuits molecular mechanisms underlying these maladaptive behaviors remain elusive. Here using a mouse model, we report pathway from vesicular glutamate transporter 3 neurons in dorsal raphe nucleus to dopamine ventral tegmental area (VGluT3DRN→DAVTA) wherein population-level activity response innocuous mechanical stimuli sucrose consumption is inhibited by chronic neuropathic...
Abstract Long non-coding RNAs (lncRNAs), which are extensively transcribed from the genome, have been proposed to be key regulators of diverse biological processes. However, little is known about role lncRNAs in regulating spermatogenesis human males. Here, using microarray technology, we show altered expression testes infertile men with maturation arrest (MA) or hypospermatogenesis (Hypo), 757 and 2370 differentially down-regulated 475 163 up-regulated MA Hypo, respectively. These findings...
Nautilus is the sole surviving externally shelled cephalopod from Palaeozoic. It unique within genealogy and critical to understanding evolutionary novelties of cephalopods. Here, we present a complete pompilius genome as fundamental genomic reference on innovations, such pinhole eye biomineralization. shows compact, minimalist with few encoding genes slow rates in both non-coding coding regions among known Importantly, multiple innovations including gene losses, independent contraction...
In recent years, researches focusing on PIWI-interacting RNAs (piRNAs) have increased rapidly. It has been revealed that piRNAs strong association with a wide range of diseases; thus, it becomes very important to understand piRNAs' role(s) in disease diagnosis, prognosis and assessment treatment response. We searched more than 2500 articles using keywords, such as `PIWI-interacting RNAs' `piRNAs', further scrutinized the collect piRNAs-disease data. These data are highly complex...
Three-dimensional chromatin structures undergo dynamic reorganization during mammalian spermatogenesis; however, their impacts on gene regulation remain unclear. Here, we focused understanding the structure-function of meiotic chromosomes by Hi-C and other omics techniques in mouse spermatogenesis across five stages. Beyond confirming recent reports regarding changes compartmentalization topologically associating domains (TADs), further demonstrated that loops are present prior to after, but...
PTPN12 is an important tumor suppressor that plays critical roles in various physiological processes. However, the molecular basis underlying substrate specificity of remains uncertain. Here, enzymological and crystallographic studies have enabled us to identify two distinct structural features are crucial determinants specificity: pY+1 site binding pocket specific basic charged residues along its surface loops. Key structurally plastic regions recognition different HER2 phosphorylation...
Abstract The brain is known to express many long noncoding RNAs (lncRNAs); however, whether and how these lncRNAs function in modulating synaptic stability remains unclear. Here, we report a cerebellum highly expressed lncRNA, Synage , regulating via at least two mechanisms. One through the of as sponge for microRNA miR-325-3p, regulate expression cerebellar synapse organizer Cbln1 . other serve scaffold organizing assembly LRP1-HSP90AA1-PSD-95 complex PF-PC synapses. Although somewhat...
Long noncoding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) is nuclear-located and transcribed from chromatin 11. To date, little known about the cellular functions regulatory mechanisms of NEAT1 in prostate cancer (PCa). In this study, whole-genome sequencing data were downloaded TCGA GEO databases. Biological information was used to analyze different expressions NEAT1. situ hybridization (ISH) performed detect expression PCa paracarcinoma clinical samples. Then, knocked down...
Enhancer–promoter communication is known to regulate spatiotemporal dynamics of gene expression. Several methods are available capture enhancer–promoter interactions, but they either require large amounts starting materials and costly, or provide a relative low resolution in chromatin contact maps. Here, we present nicking enzyme-assisted open interaction (NicE-C), method that leverages enzyme–mediated profiling chromosome conformation enable robust cost-effective detection interactions at...
It is known that the long noncoding RNAs (lncRNA) MALAT1 associated with tumorigenesis and progression in various cancers; however, its functions mechanisms prostate cancer (PCa) initiation are still unknown. In present study, our findings revealed plays a critical part regulating PCa proliferation glucose metabolism. Knockdown of affects protein mRNA levels MYBL2. addition, enhances phosphorylation level mTOR pathway by upregulating or MYBL2 cell lines significantly inhibits their capacity....