A5101754419- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Soil erosion and sediment transport
- Pharmacogenetics and Drug Metabolism
- vaccines and immunoinformatics approaches
- Viral Infections and Vectors
- Drug Transport and Resistance Mechanisms
- Medicinal Plants and Bioactive Compounds
- Soil Carbon and Nitrogen Dynamics
- Berberine and alkaloids research
- Animal Disease Management and Epidemiology
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer-related molecular mechanisms research
- Chemical Synthesis and Analysis
- Hydrology and Sediment Transport Processes
- Flavonoids in Medical Research
- Soil Geostatistics and Mapping
- Heme Oxygenase-1 and Carbon Monoxide
- Stroke Rehabilitation and Recovery
- Mosquito-borne diseases and control
- Chromosomal and Genetic Variations
- Pain Mechanisms and Treatments
- Endometriosis Research and Treatment
- Natural Antidiabetic Agents Studies
- Telomeres, Telomerase, and Senescence
Bahauddin Zakariya University
2023-2025
COMSATS University Islamabad
2018-2024
Aga Khan University Hospital Nairobi
2024
University of Science and Technology of China
2017-2019
Hefei National Center for Physical Sciences at Nanoscale
2019
Center for Excellence in Molecular Cell Science
2017
University of Agriculture Faisalabad
2016
The Ohio State University
2016
Purple soil is widely distributed in the hilly areas of Sichuan basin, southwest China, and highly susceptible to water erosion. The triggering this process related slope, rainfall intensity surface cover. Therefore, study assesses effects different simulated intensities with slopes on hydrological erosional processes un-mulched mulched purple soils. Results show that sediment losses increased an increase slope steepness. Generally, contribution (Sc) decreased increasing steepness under both...
In recent years, researches focusing on PIWI-interacting RNAs (piRNAs) have increased rapidly. It has been revealed that piRNAs strong association with a wide range of diseases; thus, it becomes very important to understand piRNAs' role(s) in disease diagnosis, prognosis and assessment treatment response. We searched more than 2500 articles using keywords, such as `PIWI-interacting RNAs' `piRNAs', further scrutinized the collect piRNAs-disease data. These data are highly complex...
Background/Objectives: Glimepiride (GLM), a commonly used sulphonylurea drug for the management of type 2 diabetes mellitus (T2DM), has been subject numerous studies exploring its kinetic behaviors. However, comprehensive evaluation that synthesizes all available pharmacokinetic (PK) data across diverse populations remains limited. This systematic review aims to provide detailed knowledge about pharmacokinetics (PK), associated pharmacodynamics (PD), and interactions GLM, which can be assess...
Abstract Ethnopharmacological relevance Aconitum tanguticum (Maxim.) Stapf (ATS) is a rare Tibetan medicinal plant that belongs to the Ranunculaceae family. This herb mainly distributed in high-altitude areas of Qinghai, Gansu provinces, and Autonomous Region China. In medicine, ATS used treat lung inflammation, hepatitis, gastrointestinal diseases, influenza, fever caused by infectious food poisoning, snake scorpion bites, yellow water disease. has anti-inflammatory, antiviral, other...
Background: ATP-binding cassette Super-family G member 2 protein is an active ATPbinding transporter with the potential to combat cancer stem cells. Objective: Due lack of inhibitors, we screened natural which could be a safe source control multidrug resistance by blocking regulation protein. Methods: Three-dimensional structure downloaded from databank and chemical structures 166 selected compounds training dataset were retrieved PubChem. Drug-likeness docking analysis was conducted...
Our previous research studies have shown that <em>Veratrilla baillonii</em> Franch (<em>V</em>. baillonii), a food supplement used by ethnic minorities in Southwest China, has multiple pharmacological activities, such as detoxification, anti-inflammatory, antioxidant, and anti-insulin resistance. However, the detailed signal pathways for its salutary effect on damages multiple organs due to type 2 diabetes mellitus...
This manuscript was aimed to explore the hepato-protective effect of water extract Veratrilla baillonii Franch. (Gentianaceae) (WVBF) on serious hepatic toxicity induced in mice treated with Aconitum brachypodum Diels (Ranunculaceae) at transcriptome level. The physiological and pathological symptoms were evaluated as markers for hepato by A. (CFA) extracted compounds. Moreover, gene chip method used compare investigate expression level WVBF CFA induced-liver identify potential target liver....
Secreted Frizzled-Related Protein 4 (SFRP4) is a glycoprotein that acts as competitor of both canonical and non-canonical Wnt pathways. SFRP4 mostly expressed in ovary plays significant role target molecule to cure ovarian carcinoma.Multiple chemical agonists are being used melanoma. We interested theoretically analyzing the compounds through computational approaches for their potential inhibitory effects against SFRP4.Compounds were sketched Chemsketch drawing tool minimized chimera tool....
Objective: The objective of the study was to explore potential signaling mechanism Aconitum tanguticum (Maxim.) Stapf (ATS) and its impact on intestinal fibrosis in vitro . Methods: Network pharmacology used screen active components ATS predict their targets fibrosis. protein–protein interaction network graph constructed using drug–disease intersection retrieved from Search Tool for Retrieval Interacting Genes/Proteins database. diagram analyzed Cytoscape 3.6.1’stopology function. gene...
<title>Abstract</title> <bold>Ethnopharmacological relevance</bold> <italic>Aconitum tanguticum</italic>(Maxim.) Stapf (ATS) is a rare Tibetan medicine belonging to the genus Ranunculaceae. This herb mainly distributed in high altitude’s areas of Qinghai, Gansu and Tibet province China. In medicine, ATS used for lung inflammation disease, hepatitis, gastrointestinal diseases, influenza, fever caused by infectious food poisoning, snake scorpion bite yellow water disease. contains...
Abstract Objective To elucidate the mechanism of therapeutic action Folium Artemisiae Argyi (FAA) on Neuropathic Pain (NP) based network pharmacology, molecular docking and experimental verification. Methods The components FAA were screened from Traditional Chinese Medicine Systems Pharmacology database (TCMSP) predicted their targets in Swiss Target Predication platform. Then, retrieving NP Genecards other disease databases. Thereby, common medicine out by Cytoscape 3.8.2 software, STRING...