A5059644378- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Parathyroid Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Dialysis and Renal Disease Management
- Bone Metabolism and Diseases
- Mitochondrial Function and Pathology
- Vitamin D Research Studies
- Complement system in diseases
- Blood Pressure and Hypertension Studies
- Bone health and osteoporosis research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Kidney Disease and Diabetes
- Urticaria and Related Conditions
- Gout, Hyperuricemia, Uric Acid
- Sodium Intake and Health
- Cancer Genomics and Diagnostics
- Erythrocyte Function and Pathophysiology
- Osteoarthritis Treatment and Mechanisms
- Sports injuries and prevention
- Breast Cancer Treatment Studies
- Potassium and Related Disorders
- Ferroptosis and cancer prognosis
- Clostridium difficile and Clostridium perfringens research
- Breast Lesions and Carcinomas
Cangzhou Central Hospital
2024-2025
First Affiliated Hospital of Jiangxi Medical College
2025
Jiangxi Provincial People's Hospital
2025
Perron Institute for Neurological and Translational Science
2019-2024
The University of Western Australia
2019-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
Chengdu University of Traditional Chinese Medicine
2024
Chongqing Public Health Medical Center
2024
Chongqing Medical University
2024
Summary Background and objectives Previous study revealed that complement activation products of the alternative pathway could be detected in renal specimens human ANCA-associated vasculitis. The current aimed to investigate clinical pathologic significance urine kidneys patients with Design, setting, participants, & measurements Renal biopsy from 29 vasculitis diagnosed at Peking University First Hospital January 2008 December 2010 were randomly collected. Urine samples 27 active stage...
The blood-brain barrier (BBB) acts as the crucial physical filtration structure in central nervous system. Here, we investigate role of a specific subset astrocytes regulation BBB integrity. We showed that Dmp1- expressing transfer mitochondria to endothelial cells via their endfeet for maintaining Deletion Mitofusin 2 ( Mfn2 ) gene Dmp1 -expressing inhibited mitochondrial and caused leakage. In addition, decrease MFN2 contributes age-associated reduction efficiency thus compromises...
The complement system is crucial for the development of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). In particular, C5a plays a central role. this study, plasma and urinary levels as well renal receptors (CD88 C5L2) expression were investigated in patients with AAV.Twenty-four AAV active phase, 19 remission 20 lupus nephritis (LN) included. Plasma measured enzyme-linked immunosorbent assay (ELISA). staining CD88 C5L2 specimens was detected immunohistochemistry.The...
Summary Testosterone (T) and vitamin D (VD) interact in androgen deficient men, however, this interaction subsequent semen quality bone mineral density (BMD) status is not clear infertile men. Our objective was to investigate T, VD, quality, BMD their relationships Chinese We conducted a cross‐sectional study of 559 men aged 20–40 years, including 195 fertile 9 with known risk factors for osteoporosis (WR) 355 without (WOR). WOR constituted 314 oligo‐, astheno‐, teratospermic or normospermic...
Although a high incidence of cardiovascular disease (CVD) is observed among chronic kidney (CKD) patients in developed countries, limited information available about CVD prevalence and risk factors the Chinese CKD population. The Cohort Chronic Kidney Disease (C-STRIDE) was established to investigate patients.
Mitochondrial transfer plays a crucial role in the regulation of tissue homeostasis and resistance to cancer chemotherapy. Osteocytes have interconnecting dendritic networks are model investigate its mechanism. We demonstrated, primary murine osteocytes with photoactivatable mitochondria (PhAM)floxed MLO-Y4 cells, mitochondrial visualized by high-resolution confocal imaging. Normal transferred adjacent metabolically stressed restored their metabolic function. The coordinated movement within...
Abstract Objective: We aimed to examine the association between dietary S e intake and CVD risk in Chinese adults. Design: This prospective cohort study included adults above 20 years old China Health Nutrition Survey (CHNS), they were followed up from 1997 2015 ( n 16 030). Dietary data retrieved CHNS, a 3-d, 24-h recall of food was used assess cumulative average e, which divided into quartiles. The Cox proportional hazards model adopted analyse incident risk. Setting: CHNS (1991, 1993,...
Abstract Inhibition of osteoclasts formation and bone resorption by estrogen is very important in the etiology postmenopausal osteoporosis. The mechanisms this process are still not fully understood. Recent studies implicated an role microRNAs estrogen‐mediated responses various cellular processes, including cell differentiation proliferation. Thus, we hypothesized that these regulatory molecules might be estrogen‐decreased resorption. Western blot, quantitative real‐time polymerase chain...
ABSTRACT Myasthenia gravis (MG) presents with symptoms that significantly affect patients' daily lives. Long‐term MG therapies may lead to substantial side effects, predominantly due prolonged immune suppression. Sirt6, which plays a vital role in maintaining cellular homeostasis and is recognised for its involvement cytokine production cells, has not yet been explored relation MG. PBMCs CD4 + T cells were isolated from blood samples. RT‐qPCR, western blot ELISA used assess the expression of...
Cisplatin (DDP) resistance remains a primary cause of chemotherapy failure and recurrence non-small cell lung cancer (NSCLC). Abnormal high microsomal glutathione transferase 1 (MGST1) expression has been found in DDP-resistant NSCLC cells. This study aimed to explore the function mechanism MGST1 DDP The levels target molecules were assessed by quantitative real-time polymerase chain reaction (RT-qPCR) western blotting. Cell proliferation was evaluated counting kit-8 (CCK-8) colony formation...
Abstract In a previous series we have shown poor short‐term (3–5 years) survival for patients with tumours overexpressing the c‐ erb B‐2 oncoprotein. this study employed archival paraffin‐embedded tissue from who underwent mastectomy 10–12 years prior to assessment ( n = 187). Immunohistochemical staining was carried out by an indirect immunoperoxidase technique using novel monoclonal antibody NCL‐CBll. Tumours were scored according intensity of membrane staining. Patient and tumour...
Abstract Osteoporosis and Alzheimer’s disease (AD) mainly affect older individuals, the possibility of an underlying link contributing to their shared epidemiological features has rarely been investigated. In current study, we investigated association between levels plasma sclerostin (SOST), a protein primarily produced by bone, brain amyloid-beta (Aβ) load, pathological hallmark AD. The study enrolled participants meeting set screening inclusion exclusion criteria were stratified into Aβ− (...
Background The complement system is crucial for the development of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). In particular, C5a and its receptor on neutrophils, CD88, play a central role. functional role second C5a, C5L2, remains unclear. current study, we investigated C5L2 in C5a-primed neutrophils ANCA-induced activation. Methods effect blocking by anti-human were tested respiratory burst degranulation activated with ANCA, as well membrane-bound proteinase 3...
Abstract 15-Lipoxygenase-1 (15-LO-1) is involved in many pathological processes. The purpose of this study was to determine the potential role 15-LO-1 osteoarthritis (OA). levels expression were measured by western blotting and quantitative real-time PCR articular cartilage from OA rat models patients. To further investigate effects on chondrocyte functions, such as extracellular matrix (ECM) secretion, release matrix-degrading enzymes, production reactive oxygen species (ROS), cell...
Background It is unclear whether short‐term blood pressure variability associated with renal outcomes in patients chronic kidney disease. Methods and Results This study analyzed data from participants the C‐ STRIDE (Chinese Cohort Study of Chronic Kidney Disease) who had disease stages 1 to 4. Short‐term was measured by calculating weighted SD (w‐ ) systolic ( SBP ). Renal were defined as dialysis initiation and/or transplantation. Risk factors w‐ evaluated linear regression. Associations...
Glucocorticoid (GC) is one of frequently used anti-inflammatory agents, but its administration unfortunately accompanied with bone loss. Although sporadic studies indicated that osteocytes are subject to a series pathological changes under GC stress, including overexpression cathepsin K, the definite role in GC-induced loss remains largely unclear.Gene expression Ctsk and protein levels K were assessed MLO-Y4 cell lines exposed dexamethasone (Dex) different time (0, 12, 24 hours) dose 10-8...
Background: Anti-neutrophil cytoplasmic antibody associated vasculitis (AAV) is a typical disease of the elderly. In AAV, there an age-specific increase in incidence with age being predictor outcome. this study, we aimed to determine contribution development AAV employing mouse model anti-myeloperoxidase (MPO) antibody-mediated glomerulonephritis. Methods: Anti-MPO IgG and lipopolysaccharide (LPS)-mediated glomerulonephritis was induced 3- 18-month-old C57Bl6 mice. Clinical pathological...