A5100445116- Renal Diseases and Glomerulopathies
- Blood Pressure and Hypertension Studies
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Bone health and osteoporosis research
- Sodium Intake and Health
- Cardiovascular Health and Disease Prevention
- Systemic Lupus Erythematosus Research
- Bone and Joint Diseases
- Cardiovascular Function and Risk Factors
- Sepsis Diagnosis and Treatment
- Renin-Angiotensin System Studies
- Kidney Stones and Urolithiasis Treatments
- Complement system in diseases
- Spondyloarthritis Studies and Treatments
- Cardiac Imaging and Diagnostics
- Organ Transplantation Techniques and Outcomes
- Pancreatitis Pathology and Treatment
- Cardiovascular Disease and Adiposity
- Lipid metabolism and disorders
- Thyroid Cancer Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Platelet Disorders and Treatments
- Hormonal Regulation and Hypertension
Peking University
2015-2025
Peking University First Hospital
2015-2025
Sichuan University
2017-2025
West China Hospital of Sichuan University
2017-2025
Peking University People's Hospital
2014-2025
Tongji University
2025
Tongji Hospital
2025
National Health and Family Planning Commission
2020-2024
First Affiliated Hospital of Nanchang University
2019-2024
Nanchang University
2019-2024
We sought to investigate the characteristics, survival and risk factors for mortality in Chinese patients with connective tissue disease (CTD)-associated pulmonary arterial hypertension (APAH) modern therapy era. 129 consecutive adult who visited one of three referral centres China a diagnosis CTD-APAH confirmed by right heart catheterisation during previous 5 years were enrolled. The end-point was all-cause death or data censoring. Systemic lupus erythematosus most common underlying CTD...
Acute kidney injury (AKI) is a frequent complication of cardiopulmonary bypass (CPB). Serum creatinine (SCr), the current standard, an inadequate marker for AKI since delay occurs before SCr rises. Biomarkers that are sensitive and rapidly measurable could allow early intervention improve patient outcomes. We investigated value serum cystatin C as biomarker after pediatric CPB.We analyzed data from 374 prospectively enrolled children undergoing CPB. samples were obtained at 2, 12, 24 hours...
<h3>BACKGROUND:</h3> Noninvasive ventilation (NIV) is increasingly used during ventilatory support. Neurally-adjusted assist (NAVA) a mode of mechanical that can improve patient-ventilator interaction. We conducted meta-analysis to compare interaction and clinical outcomes between NAVA pressure support (PSV) in adult subjects NIV. <h3>METHODS:</h3> The PubMed, Cochrane Library, Web Science, OpenGrey, Embase databases were searched for appropriate trials comparing NIV-NAVA with NIV-PSV...
Abstract Objectives To assess the risk of flare in systemic lupus erythematosus (SLE) patients after low-dose glucocorticoid (GC) discontinuation and to evaluate factors flare. Methods SLE who ever discontinued GCs were identified from Peking University First Hospital cohort. The disease profile GC was analysed. rate analysed using Kaplan–Meier analysis. Cox regression used determine effects variables on A prognostic nomogram proportional hazards modelling developed. Results total 132...
A dysfunctional endometrial renin–angiotensin system (RAS) could aid the growth and spread of cancer. To determine if RAS is altered in cancer, we measured gene expression protein levels 30 human formalin-fixed, paraffin-embedded (FFPE) endometrioid carcinomas their adjacent endometrium. All components were expressed most tumours endometrium; mRNA (pro)renin receptor ( ATP6AP2 ), angiotensin II type 1 AGTR1 angiotensin-converting enzyme ACE1 ) 2 ACE2 greater tumour tissue than non-cancerous...
To examine national trends in unhealthy lifestyle factors among adults with cardiovascular disease (CVD) the United States (US) between 1999 and 2018.We analyzed data from National Health Nutrition Examination Survey (NHANES), a nationally representative survey of participants CVD who were aged ≥20 years, which was conducted 2000 2017-2018. defined as self-report congestive heart failure, coronary disease, angina, attack, or stroke. The prevalence rate each factor calculated for 2-year cycle...
Abstract Background Oxidation-specific epitopes (OSEs) are rich in atherosclerotic plaques. Innate and adaptive immune responses to OSEs play an important role atherosclerosis. The purpose of this study was develop novel human single-chain variable fragment (scFv) antibody specific image inhibit Results Here, we screened a scFv antibody, named as ASA6, from phage-displayed library. ASA6 can bind oxidized LDL (Ox-LDL) Meanwhile, also the uptake Ox-LDL into macrophage reduce apoptosis. lesion...
Background and objectives Nocturnal hypertension is associated with adverse outcomes in patients CKD. However, the individual association of entities nocturnal according to achievement systolic and/or diastolic BP goals kidney failure cardiovascular CKD not clear. Design, setting, participants, & measurements Our study analyzed data from participants Chinese Cohort Study Chronic Kidney Disease. was categorized into three entities: isolated ≥70 mm Hg <120 Hg, ≥120 <70...
Introduction: The aim of this study was to explore the chronological trends in clinical features and utilization healthcare resources for hospitalized patients with urolithiasis China. Methods: Patients were extracted from Hospital Quality Monitoring System, a national database China, based on International Classification Diseases, Tenth Revision, codes. Variables including demographic characteristics, comorbidities, treatment modalities urolithiasis, length hospital stay, expenditures...
A20, also known as TNF-α-induced protein 3 (TNFAIP3), is a crucial negative regulator of inflammation and immune responses. Emerging evidence suggests that A20 involved in the regulation glucose metabolism plays significant role bone metabolic diseases by inhibiting nuclear factor (NF)-κB activation. However, potential relationship between serum level mineral density (BMD) patients with type 2 diabetes mellitus (T2DM) has not been explored. This study aims to investigate association BMD...
Abstract Background To investigate depression and anxiety related factors among patients receiving maintenance hemodialysis (MHD). Methods This cross-sectional study included underwent MHD in 3/2022 at Jinshan Hospital affiliated to Fudan University. Depression levels of were assessed using Beck Inventory (BDI) Anxiety (BAI), respectively. SF-36 was used assess patients’ quality life. Multiple linear regression analysis determine the variables associated with scores BDI/BAI. Results A total...
Oncologic immunotherapy is a form of therapy intended to reactivate the immune response tumor cells using agents that modulate checkpoints, such as programmed cell death protein 1 and its ligand (PD-1/PD-L), cytotoxic T-lymphocyte-associated antigen 4. Along with activation system tumors, immune-mediated kidney side effects have been reported, most which are cases interstitial nephritis. Glomerular disease, however, appears rare. Herein, we describe patient nephrotic syndrome related...
Angiotensin-(1-7) [ANG-(1-7)] acts at Mas receptors (MasR) to oppose effects of angiotensin II (ANG II). Previous studies demonstrated that protection female mice from obesity-induced hypertension was associated with increased systemic ANG-(1-7), whereas male obese hypertensive exhibited ANG II. We hypothesized MasR deficiency (MasR-/- ) augments in males and abolishes females. Male wild-type (MasR+/+ MasR-/- were fed a low-fat (LF) or high-fat (HF) diet for 16 wk. had no effect on obesity....
Objective: To investigate the prevalence rates of depression anxiety and suicidal ideation among Chinese general hospital inpatients to identify potential associations with sociodemographics.Method: A cross-sectional survey was applied in a hospital. questionnaire set, including sociodemographic variables, Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder Scale-7 (GAD-7), completed by participants. Clinically significant (CSD) clinically (CSA) were defined as score above...
First we aimed to evaluate the ability of neutrophil gelatinase-associated lipocalin (NGAL) and cystatin-C (CyC) in plasma urine discriminate between sustained, transient absent acute kidney injury (AKI), second their predictive performance for sustained AKI adult intensive care unit (ICU) patients.A prospective cohort study 700 patients was studied. Sample collection performed over 8 time points starting on admission.After exclusion 510 remained analysis. All biomarkers showed significant...