Measured at intensive care unit admission (ICU), the predictive value of neutrophil gelatinase-associated lipocalin (NGAL) for severe acute kidney injury (AKI) is unclear.To assess ability plasma and urine NGAL to predict AKI in adult critically ill patients.Prospective-cohort study consisting 632 consecutive patients.Samples were analyzed by Triage immunoassay expression. The primary outcome measure was occurrence based on Risk-Injury-Failure (RIFLE) classification during first week ICU...

Peripheral oxygen saturation (SpO2) measured by pulse oximetry is an unreliable surrogate marker for arterial oxygenation (SaO2) in critically ill patients. We hypothesized that a higher perfusion index (PFI) would be associated with better accuracy of SpO2 measurement. retrospectively collected SaO2, SpO2, and PFI data each blood gas (ABG) analysis cohort intensive care unit was categorised as low (PFI < 1.0), intermediate (1.0 ≤ 2.5), or high > 2.5). The correlation between SaO2 studied...

First we aimed to evaluate the ability of neutrophil gelatinase-associated lipocalin (NGAL) and cystatin-C (CyC) in plasma urine discriminate between sustained, transient absent acute kidney injury (AKI), second their predictive performance for sustained AKI adult intensive care unit (ICU) patients.A prospective cohort study 700 patients was studied. Sample collection performed over 8 time points starting on admission.After exclusion 510 remained analysis. All biomarkers showed significant...

Abstract Purpose Insufficient antimicrobial exposure has been associated with worse clinical outcomes. Reportedly , flucloxacillin target attainment in critically ill patients was heterogeneous considering the study population selection and reported percentages. Therefore, we assessed pharmacokinetics (PK) patients. Methods This prospective, multicenter, observational conducted from May 2017 to October 2019 included adult, administered intravenously. Patients renal replacement therapy or...

Cefuroxime is frequently prescribed as an antimicrobial therapy in critically ill patients. The aim of this study was to develop a new intravenous dosing strategy for cefuroxime patients undergoing continuous venovenous hemofiltration with regional citrate anticoagulation (RCA-CVVH) by analyzing its extracorporeal removal and pharmacokinetic (PK) parameters.Nine treated RCA-CVVH phosphate-containing replacement fluid were investigated. Arterial effluent samples obtained from all pre-...

Intravenously administered iodine-containing contrast medium (CM) is associated with the development of contrast-induced nephropathy (CIN). Data on effectiveness sodium bicarbonate therapy in prevention CIN are controversial. Furthermore, incidence and risk factors for intensive care unit (ICU) patients poorly defined. We investigated prophylaxis a heterogeneous ICU population.This retrospective cohort study included admitted to 2009-2011 who received CM computed tomography (CT).Two hundred...

Abstract Background Pharmacokinetic studies of cefuroxime by ultra‐performance liquid chromatography tandem mass spectrometry (UPLC‐MS/MS) have been limited to measurements total concentrations. Here, we developed a robust method for quantifying and unbound concentrations using UPLC‐MS/MS ultrafiltration in critically ill patients with hypoalbuminemia renal failure. Methods Method validation included accuracy, linearity, precision, repeatability, recovery, limit quantification (LOQ)....

The microcirculatory control of flow was studied in the cremaster muscle 5- to 6-week-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) using intravital microscopic techniques. Arterioles were classified according a functional branching order from A1-A4 vessels. Capillary architecture measured separate series experiments. No significant differences found WKY or SHR vessel diameters, with exception third-order arterioles, which slightly, but significantly, larger SHR. However,...

Objectives To study the effects of running with/without use pain killers on urinary neutrophil gelatinase‐associated lipocalin (uNGAL) and other parameters kidney function in recreational runners. Methods Participants 10‐ 21.1‐km Weir Venloop race were enrolled their urine samples collected before after run. Urine dipstick conventional tests used to assess performed. The presence ibuprofen, diclofenac, naproxen, and/or paracetamol was assessed by LC‐MS/MS. uNGAL measured with a two‐step...

OBJECTIVES: To develop a reliable ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for therapeutic drug monitoring (TDM) of unbound ciprofloxacin concentrations in critically ill patients. METHODS: Total and five randomly selected intensive care unit (ICU) patients were measured using UPLC-MS/MS. Method validation included accuracy, linearity, precision, repeatability, limits detection quantification. RESULTS: The median fraction was 74.8%, with area under...

During the coronavirus disease 2019 (COVID-19) pandemic, sedative prescriptions surged, leading to shortages of midazolam. This study investigates lormetazepam as an adjunct alternative midazolam for mechanically ventilated patients with COVID-19. We aimed determine clinical pharmacokinetics (PK) enterally administered and provide dosing recommendations. Critically ill acute respiratory distress syndrome (ARDS) or COVID-19 requiring mechanical ventilation were enrolled in April 2020....

Low-molecular-weight heparins are frequently used to prevent venous thromboembolism. Vasopressor therapy may be associated with inadequate anti-factor Xa activity, thereby increasing the risk of We aimed assess association between activity and norepinephrine dose in intensive care unit (ICU) patients treated subcutaneous dalteparin for thromboembolism prophylaxis.This was a prospective observational pilot study adult ICU 5,000 IU subcutaneously once daily > 0.25 µg/kg/min. Peak monitored...

Nonsteroidal anti-inflammatory drugs are frequently used by athletes in order to prevent musculoskeletal pain and improve performance. In combination with strenuous exercise, they can contribute a reduction of renal blood flow promote development kidney damage. We aimed investigate whether monomeric oligomeric flavanols (MOF) could reduce the severity injuries associated intake 400-mg ibuprofen followed completion half-marathon recreational athletes. this double-blind, randomized study,...

To investigate drug concentration of trimethoprim-sulfamethoxazole (TMP-SMX) using therapeutic monitoring (TDM) for severe Pneumocystis jirovecii (PJP) infection in a critically ill patient with COVID-19 receiving continuous venovenous hemofiltration treatment and regional citrate anticoagulation (RCA-CCVH).A 72-year-old man hypoxemic respiratory failure due to was admitted the intensive care unit invasive mechanical ventilation. The developed acute renal that required RCA-CVVH. Pulmonary...

Background: Abnormal red cell distribution width (RDW) is associated with poor cardiovascular, respiratory, and coronavirus disease 2019 (COVID-19) outcomes. However, whether RDW provides prognostic insights regarding COVID-19 patients admitted to the intensive care unit (ICU) was unknown. Here, we retrospectively investigated association of 30-day 90-day mortalities, duration mechanical ventilation, length ICU hospital stay in COVID-19.Methods: This study included 321 aged &gt;18 years who...

To develop a reliable 2-compartment population pharmacokinetic (PK) model for unbound ceftriaxone in critically ill and determine an optimal dosing regimen.This was prospective, single-center, observational study of patients treated with ceftriaxone. Unbound serum concentrations were measured using validated ultrafiltration ultra-performance liquid chromatography-tandem mass spectrometry. PK analysis simulations performed iterative 2-stage Bayesian fitting procedure Monte Carlo simulations....