A5100648494- Tendon Structure and Treatment
- Sports injuries and prevention
- Bone Tissue Engineering Materials
- Shoulder Injury and Treatment
- Reproductive Biology and Fertility
- Laser Applications in Dentistry and Medicine
- Assisted Reproductive Technology and Twin Pregnancy
- Botulinum Toxin and Related Neurological Disorders
- Biofuel production and bioconversion
- Ovarian function and disorders
- Electrospun Nanofibers in Biomedical Applications
- Mitochondrial Function and Pathology
- Silk-based biomaterials and applications
- Orthopedic Surgery and Rehabilitation
- Knee injuries and reconstruction techniques
- Shoulder and Clavicle Injuries
- Corporate Social Responsibility Reporting
- Planarian Biology and Electrostimulation
- Breast Lesions and Carcinomas
- Magnetic and Electromagnetic Effects
- Barrier Structure and Function Studies
- Ferroptosis and cancer prognosis
- Geothermal Energy Systems and Applications
- Ectopic Pregnancy Diagnosis and Management
- Orbital Angular Momentum in Optics
The University of Western Australia
2017-2024
Hebei Medical University
2024
Hebei General Hospital
2024
Cathay General Hospital
2024
Guangxi University
2023
Zhejiang University of Technology
2023
Monash University
2023
Australian Research Council
2018-2022
Perron Institute for Neurological and Translational Science
2022
Shenzhen Zhongshan Urological Hospital
2019-2020
The blood-brain barrier (BBB) acts as the crucial physical filtration structure in central nervous system. Here, we investigate role of a specific subset astrocytes regulation BBB integrity. We showed that Dmp1- expressing transfer mitochondria to endothelial cells via their endfeet for maintaining Deletion Mitofusin 2 ( Mfn2 ) gene Dmp1 -expressing inhibited mitochondrial and caused leakage. In addition, decrease MFN2 contributes age-associated reduction efficiency thus compromises...
Alveolar bone loss is a common problem that affects dental implant placement. A barrier between the substitute and gingiva can prevent fibro-tissue ingrowth, bacterial infection induce formation key factor in improving success of alveolar ridge reconstruction. This study aims to develop bioactive collagen material for guided regeneration, coupled with anti-bacterial anti-inflammatory properties. We have evaluated two silver coating methods found controllable precise achieved by sonication...
Obesity is a well-recognised risk factor for osteoarthritis (OA). Our aim to characterise body mass index (BMI)-associated pathological changes in the osteochondral unit and determine if obesity major causal antecedent of early joint replacement patients with OA.We analysed correlation between BMI age at which undergo total knee (TKR) 41 023 from Australian Orthopaedic Association National Joint Replacement Registry. We then investigated effect on tibia plateau representative subset...
Abstract Tendinopathy is one of the most common musculoskeletal diseases, and mechanical overload considered its primary cause. However, underlying mechanism through which induces tendinopathy has not been determined. In this study, we identified for first time that tendon cells can release extracellular mitochondria (ExtraMito) particles, a subtype medium particles (mEPs), into environment process regulated by loading. RNA sequencing systematically revealed oxygen-related reactions,...
Biopolymers play a critical role as scaffolds used in tendon and ligament (TL) regeneration. Although advanced biopolymer materials have been proposed with optimised mechanical properties, biocompatibility, degradation, processability, it is still challenging to find the right balance between these properties. Here, we aim develop novel hybrid biocomposites based on poly(p-dioxanone) (PDO), poly(lactide-co-caprolactone) (LCL) silk produce high-performance grafts suitable for TL tissue...
The interface tissue between bone and soft tissues, such as tendon ligament (TL), is highly prone to injury. Although different biomaterials have been developed for TL regeneration, few address the challenges of TL-bone interface. Here, we aim develop novel hybrid nanocomposites based on poly(p-dioxanone) (PDO), poly(lactide-co-caprolactone) (LCL), hydroxyapatite (HA) nanoparticles suitable repair. Nanocomposites, containing 3-10% both unmodified chemically modified (mHA) with a silane...
Finding the right balance in mechanical properties and degradation rate of biodegradable materials for biomedical applications is challenging, not only at time implantation but also during biodegradation. For instance, high elongation break toughness with a mid-term are required tendon scaffold or suture application, which cannot be found each alpha polyester individually. Here, we hypothesise that blending semi-crystalline poly(p-dioxanone) (PDO) poly(lactide-co-caprolactone) (LCL) specific...
Rotator Cuff (RC) tendon tearing is a common clinical problem and there high incidence of revision surgery due to re-tearing. In an effort improve patient outcome reduce surgical revision, scaffolds have been widely used for augmentation RC repairs. However, little known about how support stem cell growth or facilitate regeneration. The purpose this study evaluate the structural biological properties bioactive collagen scaffold (BCS) with potential promote repair. Additionally, we conducted...
Botulinum toxin (Botox) injection is in widespread clinical use for the treatment of muscle spasms and tendinopathy but mechanism action poorly understood. We hypothesised that reduction patellar-tendon mechanical-loading following intra-muscular Botox results tendon atrophy at least part mediated by induction senescence tendon-derived stem cells (TDSCs). Controlled laboratory study METHODS: A total 36 mice were randomly divided into 2 groups (18 Botox-injected 18 vehicle-only control). Mice...
Tendons are the force transferring tissue that enable joint movement. Excessive mechanical loading is commonly considered as a primary factor causing tendinopathy, however, an increasing body of evidence supports hypothesis overloading creates microdamage collagen fibers resulting in localized decreased on cell population within damaged site. Heterotopic ossification complication late stage which can significantly affect properties and homeostasis tendon. Here, we examine effect underloading...
Early rescue intracytoplasmic sperm injection (ICSI) has been used in clinic as appropriate currently. While the outcomes of children born after this method were not well assessed. The purpose study was to evaluate effect early ICSI on women with primary infertility.Fresh embryo transfer cycles (n = 214) and conventional 546) retrospectively evaluated from infertility who underwent their first assisted reproductive technology at our center 2012-2017. group subdivided into ICSI-1 (semen...
Tendinopathy is a common chronic tendon disease relating to inflammation and degeneration in an orthopaedic area. With high morbidity, limited self-repairing capacity and, most importantly, no definitive treatments, tendinopathy still influences patients' life quality negatively. Tendon-derived stem cells (TDSCs), as primary precursor of cells, play essential role both the development tendinopathy, functional structural restoration after tendinopathy. Thus, method that can vitro mimic vivo...