A5067961035- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Additive Manufacturing and 3D Printing Technologies
- Advanced Sensor and Energy Harvesting Materials
- Cellular Mechanics and Interactions
- Tissue Engineering and Regenerative Medicine
- Bone Tissue Engineering Materials
- Tendon Structure and Treatment
- Fusion materials and technologies
- Cancer Cells and Metastasis
- Microtubule and mitosis dynamics
- Silk-based biomaterials and applications
- Mesenchymal stem cell research
- Diamond and Carbon-based Materials Research
- Force Microscopy Techniques and Applications
- Electrohydrodynamics and Fluid Dynamics
- Corneal Surgery and Treatments
- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Neurogenesis and neuroplasticity mechanisms
- Ion-surface interactions and analysis
- Knee injuries and reconstruction techniques
- Nuclear Materials and Properties
- Conducting polymers and applications
- Advanced Machining and Optimization Techniques
Harry Perkins Institute of Medical Research
2020-2024
The University of Western Australia
2020-2024
Queen Elizabeth II Medical Centre
2020-2024
Curtin University
2023-2024
Queensland University of Technology
2013-2022
The University of Queensland
2019
Universidad de Navarra
2009-2015
Monash University
2015
Centro de Estudios e Investigaciones Técnicas de Gipuzkoa
2011-2014
University of California, Berkeley
2006-2011
Glioblastoma multiforme (GBM) is a malignant astrocytoma of the central nervous system associated with median survival time 15 months, even aggressive therapy. This rapid progression due in part to diffuse infiltration single tumor cells into brain parenchyma, which thought involve aberrant interactions between and extracellular matrix (ECM). Here, we test hypothesis that mechanical cues from ECM contribute key cell properties relevant invasion. We cultured series glioma lines (U373-MG,...
The additive manufacturing of highly ordered, micrometer-scale scaffolds is at the forefront tissue engineering and regenerative medicine research. fabrication for regeneration larger volumes, in particular, remains a major challenge. A technology convergence electrospinning-melt electrospinning writing (MEW)-is also limited thickness/volume due to accumulation excess charge from deposited material repelling hence, distorting scaffold architectures. underlying physical principles are studied...
Abstract Heart valves are characterized to be highly flexible yet tough, and exhibit complex deformation characteristics such as nonlinearity, anisotropy, viscoelasticity, which are, at best, only partially recapitulated in scaffolds for heart valve tissue engineering (HVTE). These biomechanical features dictated by the structural properties microarchitecture of major constituents, particular collagen fibers. In this study, unique capabilities melt electrowriting (MEW) exploited create...
Abstract Heart valve tissue engineering (HVTE) aims to provide living autologous heart implants endowed with regenerative capabilities and life‐long durability. However, fabrication of biomimetic scaffolds capable providing the required functionality in terms mechanical performance tunable porosity enable cellular infiltration remains a major challenge. Here, additive manufacturing bioinspired, spatially heterogeneous, tubular enclosing leaflets, inter‐leaflet triangles, their interface for...
Abstract Adult neural stem cells (NSCs) play important roles in learning and memory are negatively impacted by neurological disease. It is known that biochemical genetic factors regulate self-renewal differentiation, it has recently been suggested mechanical solid-state cues, such as extracellular matrix (ECM) stiffness, can also the functions of NSCs other cell types. However, relatively little molecular mechanisms through which transduce inputs into fate decisions, extent to instruct...
Protein N-terminal acetylation (Nt-acetylation) is an important mediator of protein function, stability, sorting, and localization. Although the responsible enzymes are thought to be fairly well characterized, lack identified in vivo substrates, occurrence Nt-acetylation substrates displaying yet uncharacterized acetyltransferase (NAT) specificities, emerging evidence posttranslational Nt-acetylation, necessitate use genetic models quantitative proteomics. NatB, which targets Met-Glu-,...
Articular cartilage from a material science point of view is soft network composite that plays critical role in load-bearing joints during dynamic loading. Its structure, consisting collagen fiber and hydrated proteoglycan matrix, gives rise to the complex mechanical properties tissue including viscoelasticity stress relaxation. Melt electrospinning writing allows design fabrication medical grade polycaprolactone (mPCL) fibrous networks for reinforcement hydrogel matrices engineering....
We present a design rationale for stretchable soft network composites engineering tissues that predominantly function under high tensile loads. The convergence of 3D-printed fibers selected from library and biodegradable interpenetrating polymer networks (IPNs) result in biomimetic tissue engineered constructs (bTECs) with fully tunable properties can match specific requirements. our technology platform using an exemplary composite model is characterized to be flexible, yet ∼125 times...
The manufacture of fibrous scaffolds with tailored micrometric features and anatomically relevant three-dimensional (3D) geometries for soft tissue engineering applications remains a great challenge. Melt electrowriting (MEW) is an advanced additive manufacturing technique capable depositing predefined fibers. However, it has been so far inherently limited to simple planar tubular scaffold because the need avoid polymer jet instabilities. In this work, we surmount technical boundaries MEW...
Melt electrowriting (MEW) combines the fundamental principles of electrospinning, a fibre forming technology, and 3D printing. The process, however, is highly complex quality fabricated structures strongly depends on interplay key printing parameter settings including processing temperature, applied voltage, collection speed, pressure. These parameters act in unison, comprising principal forces electrified jet: pushing viscous polymer out nozzle mechanically electrostatically dragging it for...
Substrate stiffness, biochemical composition, and matrix topography deeply influence cell behavior, guiding motility, proliferation, differentiation responses. The aim of this work was to determine the effect that stiffness protein composition underlying substrate has on induced pluripotent stem (iPS) cells potential synergy with specific soluble cues. With purpose, murine iPS-derived embryoid bodies (iPS-EBs) were seeded fibronectin- or collagen I-coated polyacrylamide (pAA) gels tunable...
A skin window enables noninvasive, longitudinal monitoring of cancer growth and therapy response in tissue-engineered bone mice.
Three-dimensionally (3D) printed scaffolds and cell culture lattices with microscale features are increasingly being used in tissue engineering regenerative medicine. One additive manufacturing technology to design fabricate such structures is melt electrowriting (MEW), a process which needs be scaled production effectively translate industrial applications. In this study, scale-up printer, designed eight simultaneously extruding heads, constructed validated. Importantly, identical could...