A5000012200- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Bone fractures and treatments
- Orthopaedic implants and arthroplasty
- Periodontal Regeneration and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Electrospun Nanofibers in Biomedical Applications
- Dental Implant Techniques and Outcomes
- Mesenchymal stem cell research
- 3D Printing in Biomedical Research
- Molecular Biology Techniques and Applications
- AI in cancer detection
- Antifungal resistance and susceptibility
- biodegradable polymer synthesis and properties
- Sleep and related disorders
- Hernia repair and management
- Parasitic Diseases Research and Treatment
- Microbial infections and disease research
- Hydrogels: synthesis, properties, applications
- Sleep and Wakefulness Research
- Ethnobotanical and Medicinal Plants Studies
- Curcumin's Biomedical Applications
- Supramolecular Self-Assembly in Materials
- Circadian rhythm and melatonin
- Digital Imaging for Blood Diseases
Queensland University of Technology
2015-2025
Australian Research Council
2022-2024
ARC Centre of Excellence in Advanced Molecular Imaging
2021-2023
Queensland Children’s Hospital
2022
The University of Queensland
2020
A preclinical evaluation using a regenerative medicine methodology comprising an additively manufactured medical-grade ε-polycaprolactone β-tricalcium phosphate (mPCL-TCP) scaffold with corticoperiosteal flap was undertaken in eight sheep tibial critical-size segmental bone defect (9.5 cm 3 , M size) the matching axial vascularization (RMAV) approach. Biomechanical, radiological, histological, and immunohistochemical analysis confirmed functional regeneration comparable to clinical gold...
Selection of decalcification agents is an essential consideration when processing mineralized tissues because the integrity and immunohistochemical characteristics may be affected. Here, we report results obtained from rat mandibles using 10% ethylenediaminetetraacetic acid (EDTA) at room temperature (RT), EDTA 37C, 5% nitric acid, formic RT. Decalcification endpoints were determined by microcomputed tomography. Morphological preservation antigenicity evaluated hematoxylin eosin staining...
The deployment of bone grafts (BGs) is critical to the success scaffold-guided regeneration (SGBR) large defects. It thus provide harvesting devices that maximize osteogenic capacity autograft while also minimizing graft damage during collection. As an alternative Reamer-Irrigator-Aspirator 2 (RIA 2) system - gold standard for large-volume used in orthopaedic clinics today a novel intramedullary BG concept has been preclinically introduced and referred as ARA (aspirator + reaming-aspiration)...
Many skeletal tissue regenerative strategies centre around the multifunctional properties of bone marrow derived stromal cells (BMSC) or mesenchymal stem/stromal (MSC)/bone stem (SSC). Specific identification these particular has been inconclusive. However, enriching heterogeneous cell populations with characterised progenitor markers a contributing factor in successful regeneration and repair strategies. In current studies we have isolated, enriched ovine (oBMSCs) using specific antibody,...
Biodegradable scaffolds with tailored mechanical and structural properties are essential for scaffold-guided soft tissue regeneration (SGSTR). SGSTR requires controllable degradation erosion characteristics to maintain integrity strength at least four six months. Additionally, these must allow porosity expansion create space the growing exhibit increased compliance match of newly formed tissue. Although progress has been made in this area, previous studies have yet fully explore aspects...
Graphical Abstract partially created with BioRender.com .
Large-volume bone defect regeneration is complex and demands time to complete. Several phases with unique characteristics, including immune responses, follow, overlap, interdepend on each other and, if successful, lead the of organ bone's form function. However, during traumatic, infectious, or neoplastic clinical cases, intrinsic capacity may exceed, surgical intervention indicated. Scaffold-guided (SGBR) has recently shown efficacy in preclinical studies. To investigate different SGBR...
The prevalent challenge facing tissue engineering today is the lack of adequate vascularization to support growth, function, and viability engineered constructs (TECs) that require blood vessel supply. research clinical community rely on increasing knowledge angiogenic vasculogenic processes stimulate a clinically-relevant vascular network formation within TECs. regenerative matching axial approach presented in this manuscript incorporates advantages flap-based techniques for...
Introduction Reconstruction of critical bone defects is challenging. In a substantial subgroup patients, conventional reconstructive techniques are insufficient. Biodegradable scaffolds have emerged as novel tissue engineering strategy for critical-sized defect reconstruction. A corticoperiosteal flap integrates the hosts’ ability to regenerate and permits creation vascular axis scaffold neo-vascularisation (regenerative matching axial vascularisation—RMAV). This phase IIa study evaluates...
Contemporary reconstructive approaches for critical size bone defects carry significant disadvantages. As a result, clinically driven research has focused on the development and translation of alternative therapeutic concepts. Scaffold-guided tissue regeneration (SGTR) is an emerging technique to heal defects. However, issues synchronizing scaffold vascularization with bone-specific regenerative processes currently limit extra large (XL, 19 cm3) To address this issue, we developed animal...
A rapid photo-curing system based on poly(2-ethyl-2-oxazoline-co-2-allylamidopropyl-2-oxazoline) and its in vivo compatibility are presented. The base polymer was synthesized from the copolymerization of 2-ethyl-2-oxazoline (EtOx) methyl ester containing 2-methoxycarboxypropyl-2-oxazoline (C3MestOx) followed by amidation with allylamine to yield a highly water-soluble macromer. We showed that spherical hydrogels can be obtained simple water-in-oil gelation method using thiol–ene coupling...
Scaffold-guided breast tissue engineering (SGBTE) has the potential to transform reconstructive surgery. Currently, there is a deficiency in clinically relevant animal models suitable for studying novel concepts. To date, only small number of large studies have been conducted and characterization these poorly described literature. Addressing this gap literature, publication comprehensively describes our original porcine model based on current published literature experience gained from...
Most histological evaluations of critical-sized bone defects are limited to the analysis a few regions interest at time. Manual and semiautomated histomorphometric approaches often have intra- interobserver subjectivity, as well variability in image methods. Moreover, production large data sets makes assessment labor intensive time consuming. Herein, we tested compared two segmentation methods: thresholding (automated) region-based (manual) modes, for quantifying complete across entire...