A5055206788- Reconstructive Surgery and Microvascular Techniques
- Cutaneous Melanoma Detection and Management
- Bone fractures and treatments
- Nonmelanoma Skin Cancer Studies
- Orthopedic Surgery and Rehabilitation
- Tissue Engineering and Regenerative Medicine
- Anatomy and Medical Technology
- Melanoma and MAPK Pathways
- Facial Trauma and Fracture Management
- Surgical Simulation and Training
- Mesenchymal stem cell research
- Reconstructive Facial Surgery Techniques
- Pectus Deformity Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Periodontal Regeneration and Treatments
- Orthopaedic implants and arthroplasty
- Trauma Management and Diagnosis
- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- CAR-T cell therapy research
- Bone Tissue Engineering Materials
- Breast Implant and Reconstruction
- Trauma and Emergency Care Studies
- Tracheal and airway disorders
- Augmented Reality Applications
Princess Alexandra Hospital
2016-2025
Royal Brisbane and Women's Hospital
2021-2025
Translational Research Institute
2022-2024
Queensland University of Technology
2020-2024
The University of Queensland
2015-2023
Queensland Children’s Hospital
2021-2023
Queensland Health
2015-2023
Redland Hospital
2022
Metro South Health
2021
Prince of Wales Hospital
2021
A preclinical evaluation using a regenerative medicine methodology comprising an additively manufactured medical-grade ε-polycaprolactone β-tricalcium phosphate (mPCL-TCP) scaffold with corticoperiosteal flap was undertaken in eight sheep tibial critical-size segmental bone defect (9.5 cm 3 , M size) the matching axial vascularization (RMAV) approach. Biomechanical, radiological, histological, and immunohistochemical analysis confirmed functional regeneration comparable to clinical gold...
Background Patients with in‐transit melanoma metastases frequently experience high rates of recurrence, limited overall survival and reduced quality life. After promising results within a Phase II, multi‐center study, PV‐10 treatment was continued at our institution for patients disease. Methodology An open‐label, non‐randomized, prospective study performed the Princess Alexandra Hospital, Queensland, Australia. were treated in accordance protocol established during previous II study. The...
Revision surgery following primary breast augmentation is common due to well-reported long-term limitations of permanent silicone implants. There are limited options for revision which avoids using Scaffold-guided tissue engineering (SGBTE) a novel technique uses scaffolds additively manufactured from medical grade polycaprolactone (mPCL), implanted and filled with autologous fat graft. This approach as observed implants the scaffold porous biodegradable. clinical trial evaluates safety...
The prevalent challenge facing tissue engineering today is the lack of adequate vascularization to support growth, function, and viability engineered constructs (TECs) that require blood vessel supply. research clinical community rely on increasing knowledge angiogenic vasculogenic processes stimulate a clinically-relevant vascular network formation within TECs. regenerative matching axial approach presented in this manuscript incorporates advantages flap-based techniques for...
Introduction Reconstruction of critical bone defects is challenging. In a substantial subgroup patients, conventional reconstructive techniques are insufficient. Biodegradable scaffolds have emerged as novel tissue engineering strategy for critical-sized defect reconstruction. A corticoperiosteal flap integrates the hosts’ ability to regenerate and permits creation vascular axis scaffold neo-vascularisation (regenerative matching axial vascularisation—RMAV). This phase IIa study evaluates...
Abstract Background The principles guiding reconstruction of the lower limb after trauma have become established over 300 years through advances in technology and studies epidemiology. This paper reviews how these came about why they are important. Methods is a structured review historical recent literature pertinent to reconstruction. outcomes assessed pre‐modern era were wound mortality, amputation mortality rate. In modern era, infection non‐union emerged as measures outcome, which...
This study assessed and compared the morbidity of nodal dissection in axilla groin including sentinel lymph node biopsy (SLNB), completion for a positive SLNB (CLND) therapeutic (TLND) with without adjuvant radiotherapy (RT).Patients who had or cutaneous melanoma over an 18-year period (1995-2013) were prospectively documented on database. The median follow-up was nearly 3 years. Early complications clinically relevant lymphoedema retrospectively analysed to assess incidence differences...
Contemporary reconstructive approaches for critical size bone defects carry significant disadvantages. As a result, clinically driven research has focused on the development and translation of alternative therapeutic concepts. Scaffold-guided tissue regeneration (SGTR) is an emerging technique to heal defects. However, issues synchronizing scaffold vascularization with bone-specific regenerative processes currently limit extra large (XL, 19 cm3) To address this issue, we developed animal...
BACKGROUND In‐transit and recurrent dermal or subcutaneous melanoma metastases represent a significant burden of advanced disease. Intralesional Rose Bengal can elicit tumor selective ablation T‐cell mediated abscopal effect in untreated lesions. A subset patients phase II trial setting received external beam radiotherapy to their lesions with complete partial response no acute radiation reaction. METHODS An open‐label, single‐arm study was performed assess the efficacy safety PV‐10 followed...
Abstract Background Current treatments for in‐transit melanoma ( ITM ) metastases are frequently invasive and do not improve overall survival. Recently, there has been increasing investigation into the use of topical agents. Diphenylcyclopropenone or diphencyprone DPCP is a novel, therapy that reported to have immune‐sensitizing properties useful in treatment . Objective To assess clinical outcomes patients treated within prospective, non‐randomized, non‐comparative study using cutaneous...
INTRODUCTION Patients with primary melanoma of the scalp have been reported to worse disease‐related outcomes compared other anatomical regions. There are few studies in literature specifically addressing recurrence patterns and treatment for as a discrete sub‐region. We sought identify key features adversely influencing disease control survival clarify role resection plane, margin, method reconstruction management this process. METHODS A retrospective clinical study medical records was...
Patients with in-transit melanoma metastases present a therapeutic challenge. Complete surgical excision of localised disease is considered as the gold standard; however, surgery not always acceptable and alternatives are required. Treatment results reported using imiquimod diphenylcyclopropenone (DPCP) suggest that topical immunotherapies can be used to successfully treat select patients metastases. A phase II, randomised, single centre, pilot study was designed assess clinical efficacy...