A5058220407- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- CAR-T cell therapy research
- Nonmelanoma Skin Cancer Studies
- Cell Image Analysis Techniques
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cutaneous lymphoproliferative disorders research
- Breast Cancer Treatment Studies
- Pelvic and Acetabular Injuries
- Case Reports on Hematomas
- Bone fractures and treatments
- Dermatological diseases and infestations
- Hip and Femur Fractures
- Brain Metastases and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Cancer Treatment and Pharmacology
- Hernia repair and management
Princess Alexandra Hospital
2015-2020
Griffith University
2013-2019
The University of Queensland
2015-2019
Queensland Health
2015-2019
Background Patients with in‐transit melanoma metastases frequently experience high rates of recurrence, limited overall survival and reduced quality life. After promising results within a Phase II, multi‐center study, PV‐10 treatment was continued at our institution for patients disease. Methodology An open‐label, non‐randomized, prospective study performed the Princess Alexandra Hospital, Queensland, Australia. were treated in accordance protocol established during previous II study. The...
Background The efficacy of immune checkpoint inhibitors (ICI) in metastatic melanoma is well established. However, there are limited data regarding their in-transit (ITM). This study assessed the ICI patients with ITM. Methods A retrospective review ITM commenced on an between March 2013 and February 2018 at three tertiary centers Australia. Patients were excluded if they had previous or synchronous distant metastases. Overall response rate (ORR), progression-free survival (PFS) overall (OS)...
BACKGROUND In‐transit and recurrent dermal or subcutaneous melanoma metastases represent a significant burden of advanced disease. Intralesional Rose Bengal can elicit tumor selective ablation T‐cell mediated abscopal effect in untreated lesions. A subset patients phase II trial setting received external beam radiotherapy to their lesions with complete partial response no acute radiation reaction. METHODS An open‐label, single‐arm study was performed assess the efficacy safety PV‐10 followed...
Abstract Background Current treatments for in‐transit melanoma ( ITM ) metastases are frequently invasive and do not improve overall survival. Recently, there has been increasing investigation into the use of topical agents. Diphenylcyclopropenone or diphencyprone DPCP is a novel, therapy that reported to have immune‐sensitizing properties useful in treatment . Objective To assess clinical outcomes patients treated within prospective, non‐randomized, non‐comparative study using cutaneous...
INTRODUCTION Patients with primary melanoma of the scalp have been reported to worse disease‐related outcomes compared other anatomical regions. There are few studies in literature specifically addressing recurrence patterns and treatment for as a discrete sub‐region. We sought identify key features adversely influencing disease control survival clarify role resection plane, margin, method reconstruction management this process. METHODS A retrospective clinical study medical records was...
Patients with in-transit melanoma metastases present a therapeutic challenge. Complete surgical excision of localised disease is considered as the gold standard; however, surgery not always acceptable and alternatives are required. Treatment results reported using imiquimod diphenylcyclopropenone (DPCP) suggest that topical immunotherapies can be used to successfully treat select patients metastases. A phase II, randomised, single centre, pilot study was designed assess clinical efficacy...
Background To assess the efficacy of diagnostic modalities used in preoperative assessment phyllodes tumours. Methods In this retrospective study patients treated at Princess Alexandra Hospital, 51 tumours 49 diagnosed between 2005 and 2016 were reviewed with regard to their findings which modalities, including clinical findings, mammography, ultrasound, fine needle aspiration core biopsy, most diagnostically discriminating. Data on demographics management also collected. Results While 90.2%...
e21072 Background: Intralesional rose bengal (IL PV-10) can elicit ablation of injected tumors and a T-cell mediated abscopal effect in untreated lesions. Phase 2 testing patients with Stage III-IV melanoma yielded 51% objective response rate (ORR) 50% complete (CR) when all disease was injected. Three who progressed received external beam radiotherapy (XRT) to their recurrent lesions an impressive without increased radiation reaction. Methods: An open-label, single-arm phase study performed...
9583 Background: The efficacy of ICIs in metastatic melanoma is well-established. However, there limited data regarding their in-transit metastases (ITM). This study assessed the ICI patients with ITM. Methods: A multisite, retrospective review ITM treated from 2004-2018. Demographic and clinicopathological factors (age, sex, primary site, AJCC version 8 stage, BRAF status, prior locoregional therapies) were collected. Objective response rate (ORR) based on a clinician-assessed best overall...
Isolated limb infusion (ILI) and intralesional PV-10 are well described locoregional therapies for in-transit melanoma. The objective of this study was to assess the effect these treatments on survival outcomes within a cohort matched key characteristics.Patients were treated using ILI or at single institution data prospectively recorded. Propensity score matching performed covariates logistic regression model. primary outcome melanoma-specific survival.Seventy-two patients nonrandomized...