A5076588308- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Skin Protection and Aging
- melanin and skin pigmentation
- Advancements in Semiconductor Devices and Circuit Design
- Metal-Organic Frameworks: Synthesis and Applications
- Nanowire Synthesis and Applications
- Olfactory and Sensory Function Studies
- Zeolite Catalysis and Synthesis
- Mesoporous Materials and Catalysis
- Neurogenesis and neuroplasticity mechanisms
- Adipose Tissue and Metabolism
- Palliative Care and End-of-Life Issues
- Pediatric health and respiratory diseases
- Cancer Cells and Metastasis
- Metal complexes synthesis and properties
- Semiconductor materials and interfaces
- Neurological disorders and treatments
- Silymarin and Mushroom Poisoning
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- X-ray Diffraction in Crystallography
- Mesenchymal stem cell research
- Crystallization and Solubility Studies
Brown University
2018-2023
Rhode Island Hospital
2019-2021
Providence College
2019-2021
Soonchunhyang University
2018
Allen Institute for Brain Science
2018
Kangbuk Samsung Hospital
2011-2017
Sungkyunkwan University
2009-2017
University of Pittsburgh
2012-2013
University of Rochester Medical Center
2012
Korea University
2008-2011
Protein N-terminal acetylation (Nt-acetylation) is an important mediator of protein function, stability, sorting, and localization. Although the responsible enzymes are thought to be fairly well characterized, lack identified in vivo substrates, occurrence Nt-acetylation substrates displaying yet uncharacterized acetyltransferase (NAT) specificities, emerging evidence posttranslational Nt-acetylation, necessitate use genetic models quantitative proteomics. NatB, which targets Met-Glu-,...
We report metal-free synthesis of high-density single-crystal elementary semiconductor nanowires with tunable electrical conductivities and systematic diameter control narrow size distributions. Single-crystal silicon germanium were synthesized by nucleation on nanocrystalline seeds subsequent one-dimensional anisotropic growth without using external catalyst. Systematic the diameters tight distribution doping concentration realized adjusting conditions, such as temperature ratio precursor...
Cell therapy with adult bone marrow multipotential stromal cells/mesenchymal stem cells (MSCs) presents a promising approach to promote wound healing and tissue regeneration. The strong paracrine capability of various growth factors cytokines is key mechanism MSC-mediated regeneration, the goal this study understand underlying that supports machineries in MSCs. Microarray database analyses revealed early response-1 (EGR1) highly expressed Our previous studies showed epidermal factor (EGF)...
While most studies have suggested multipotential stromal cell or mesenchymal stem (MSC) therapies are useful for immune-mediated diseases, MSCs' immunomodulatory effects were not entirely reproduced in some studies, indicating the necessity to determine underlying mechanism of on immune response regulation maximize their effects. We identified transcription factor early growth gene-2 (EGR2) as a novel molecular switch regulating known molecules human MSCs. EGR2 binds promoter regions these...
Toxic hepatitis is a rare but devastating disease in children. Herbs are widely used oriental medicine to treat various symptoms Korea, however, several herbs have been reported induce liver injury. We report case of toxic induced by Hovenia dulcis 3-year-old boy. He complained nausea, abdominal discomfort, and jaundice. The patient had consumed water boiled with hovenia for about 1 year prior presentation. A diagnosis was made based on his history, laboratory data, viral markers,...
Introduction Although a majority of the American public prefer to die at home, large percentage Parkinson’s disease patients in acute care hospitals. We examine trends clinical and demographic characteristics who hospital identify populations potentially vulnerable unwanted inpatient mortality. Methods Patients with admitted from 2002-2016 were identified National Inpatient Sample (n = 710,013) along their associated characteristics. The main outcome examined was mortality during admission....
Purpose: Obesity is a risk factor for asthma and type II diabetes.Peroxisome proliferator-activated receptor (PPAR)-γ has been suggested to regulate inflammatory responses in diabetes asthma.We investigated whether PPAR-α, PPAR-γ, adiponectin receptors (AdipoR1, AdipoR2), leptin, tumor necrosis (TNF)-α are expressed rat lung tissues the expression differs between obese Otsuka Long-Evans Tokushima Fatty (OLETF) lean Long Evans (LETO) rats.Materials Methods: Obese rats were given with high fat...
To understand the effects of HCN as potential mediators in pathogenesis epilepsy that evoke long-term impaired excitability; present study was designed to elucidate whether alterations expression induced by status epilepticus (SE) is responsible for epileptogenesis. Although HCN1 immunoreactivity observed hippocampus, its immunoreactivities were enhanced at 12 hrs following SE. Although, reduced all hippocampi 2 weeks, a re-increase 2-3 months SE observed. In contrast HCN1, 4 expressions...
We performed electrical transport measurements on a DNA-conjugated single-wall carbon nanotube (SWCNT) field-effect transistor (FET) at various temperatures (Ts). At T = 300 K, the gate action of SWCNT FET clearly exhibited n-type behavior, while bare showed usual p-type characteristics. The value drain current measured from decreased rapidly with decrease T. fit T-dependence simple back-to-back Schottky diode model and found slight ΦB decreasing A possible explanation for type conversion is...
Axially doped p–n silicon nanowire (SiNW) gated diodes are fabricated, and their electrical properties investigated to demonstrate the enhanced surface effects on nanoscale devices of semiconductor nanomaterials. The fabricated SiNW exhibited clear rectifying characteristics with an ideality factor ∼2. More interestingly, showed a switching behavior as function gate bias almost complete turn-off forward current. observed diode were explained trap states nanowires. Systematic 3D device...
The peripheral trigeminovascular pathway mediates orofacial and craniofacial pain projects centrally to the brainstem trigeminal nucleus caudalis (TNc). Sensitization of this is involved in many conditions, but little known about synaptic plasticity at its first central synapse. We have taken advantage optogenetics investigate selectively evoked synapses nociceptive primary afferents onto TNc neurons. Based on immunolabeling ganglia, TRPV1-lineage neurons comprise primarily peptidergic...
Dysphagia causing aspiration pneumonia is a common complication in the advanced stages of neurodegenerative disorders. Historically, physicians attempted to prevent this with gastrostomy tube (GT) placement. Its use supported amyotrophic lateral sclerosis (ALS), not Alzheimer's disease (AD), and without disease-specific guidelines Parkinson's (PD). The rate GT placement these three populations over two decades, from 1990 2010, was calculated using binomial regression model data extracted...
Parvalbumin (PV) is found in the olfactory system, including main bulb, and thought to be one of neuroactive substances olfaction. Changes PV immunoreactivity system during aging have not been examined. We investigated such changes bulb (MOB) rat at postnatal month 1 (PM 1), PM 3, 6, 12 24. PV-IR neurons were almost completely restricted external plexiform layer. At there only a few neurons; number was its greatest but they well developed morphologically. similar that 3 had satellite somata...
Though protein transduction domains (PTDs) are well known for the delivery of exogenous therapeutic proteins into living cells, overall low efficiency is a serious obstacle. We investigated effect bog blueberry anthocyanins (BBA) on and found that BBA enhanced efficiencies Tat-SOD fusion HeLa cells mice skin. The enzymatic activities in skin tissue presence were markedly increased compared to controls. Further, did not demonstrate any cell toxicity at various concentrations. Although...
We investigated the mRNA levels of peroxisome proliferator-activated receptor (PPAR)-α, PPAR-γ, adipokines, and cytokines in lung tissue lean obese mice with without ovalbumin (OVA) challenge, effect rosiglitazone, a PPAR-γ agonist.We developed 6 models: OVA-challenged rosiglitazone; rosiglitazone. performed real-time polymerase chain reaction for leptin, leptin receptor, adiponectin, vascular endothelial growth factor (VEGF), tumor necrosis (TNF)-α, transforming (TGF)-β, PPAR-α from...
We reported the fabrication and characterization of a new type silicon-on-insulator (SOI) single-electron transistor utilizing usual CMOS sidewall gate structures. used oxide spacer layers as well two poly-Si finger gates on an SOI wire mesa implantation masks, to form tunnel barriers thus quantum dot (QD) that is smaller than spacing between polygates. Characterization results exhibited clear Coulomb oscillations persisting up 30 K. The energy size QD extracted from three devices were...
We investigated the changes in parvalbumin (PV)-immunoreactive (IR) neurons parietofrontal cortex after transient forebrain ischemia. In sham-operated group, PV-IR were present all layers of except layer I. Shortly ischemia number II/III first increased, and then declined dramatically 12 h ischemic insult, followed by a second increase 2 days. At this time PV immunoreactivity was very weak only peripheral neuronal cytoplasm. The reversible level their could result from ischemia-induced...