A5079223004- 3D Printing in Biomedical Research
- Autopsy Techniques and Outcomes
- Additive Manufacturing and 3D Printing Technologies
- Traumatic Ocular and Foreign Body Injuries
- Microfluidic and Bio-sensing Technologies
- Forensic Anthropology and Bioarchaeology Studies
- Neuroscience and Neural Engineering
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced Sensor and Energy Harvesting Materials
- Paleopathology and ancient diseases
- Magnetic properties of thin films
- Quantum and electron transport phenomena
- Microfluidic and Capillary Electrophoresis Applications
- Cell Image Analysis Techniques
- Radiation Dose and Imaging
- Innovative Microfluidic and Catalytic Techniques Innovation
- Alzheimer's disease research and treatments
- Gun Ownership and Violence Research
- Traffic and Road Safety
- Older Adults Driving Studies
- Mechanical and Optical Resonators
- Prion Diseases and Protein Misfolding
- Quality and Safety in Healthcare
- Animal testing and alternatives
- Neurological Complications and Syndromes
University of Zurich
2013-2024
Max Planck Institute for Multidisciplinary Sciences
2022
Queensland University of Technology
2017-2022
Regenerative Medicine Institute
2022
University of Kaiserslautern
2022
Tissue Dynamics (Israel)
2022
Technical University of Munich
2017-2021
ETH Zurich
2019
Klinikum rechts der Isar
2017
Kantonsspital Baden
2015
Accumulating evidence suggests that the copper-binding amyloid precursor protein (APP) has an essential synaptic function. APP synaptogenic function depends on <i>trans</i>-directed dimerization of extracellular E1 domain encompassing a growth factor-like (GFLD) and (CuBD). Here we report 1.75 Å crystal structure GFLD in complex with copper ion bound high affinity to extended hairpin loop at interface. In coimmunoprecipitation assays binding promotes interaction, whereas mutations sites...
Melt electrowriting (MEW) combines the fundamental principles of electrospinning, a fibre forming technology, and 3D printing. The process, however, is highly complex quality fabricated structures strongly depends on interplay key printing parameter settings including processing temperature, applied voltage, collection speed, pressure. These parameters act in unison, comprising principal forces electrified jet: pushing viscous polymer out nozzle mechanically electrostatically dragging it for...
Skin is a critical organ that plays crucial role in defending the internal organs of body. For this reason, extensive work has gone into creating artificial models epidermis for vitro skin toxicity tests. These tissue models, called reconstructed human (RhE), are used by researchers pharmaceutical, cosmetic, and environmental arenas to evaluate upon exposure xenobiotics. Here, we present label-free solution leverages use intelligent mobile lab diagnostics (IMOLA-IVD), noninvasive,...
Three-dimensionally (3D) printed scaffolds and cell culture lattices with microscale features are increasingly being used in tissue engineering regenerative medicine. One additive manufacturing technology to design fabricate such structures is melt electrowriting (MEW), a process which needs be scaled production effectively translate industrial applications. In this study, scale-up printer, designed eight simultaneously extruding heads, constructed validated. Importantly, identical could...
Automation liberates scientific staff from repetitive tasks, decreases the probability of human error and consequently enhances reproducibility lab experiments. However, use laboratory automation in academic laboratories is limited due to high acquisition costs inability customize off-the-shelf hardware. To address these challenges, we present an Open Source Hardware concept, referred as OpenWorkstation, build assembly line-inspired platform consisting ready-to-use customizable modules. In...
While much progress has been accomplished in the development of physiologically relevant vitro disease models, current manufacturing and characterisation workflows still rely on manual, time-consuming, low-throughput processes, which are not efficient prone to human errors. For these reasons adoption and, more importantly, reproducibility validation 3D models is rather low for fundamental applied research concepts. This article argues form a perspective view that automation high-throughput...
Gelatin methacryloyl (GelMA)-based hydrogels have become highly studied as modular tissue culture platforms due to the combination of bioactivity gelatin and tailorability photo-crosslinkable hydrogels. However, current production characterization workflows still rely on manual, time-consuming, low-throughput processes, ultimately limiting widespread adaption. To address these challenges, an open-source technology platform is engineered validated for automated high-throughput GelMA-based 3D...
Microphysiometry is a powerful technique to study metabolic parameters and detect changes external stimuli. However, applying this for automated label-free real-time measurements within cell-laden three-dimensional (3D) cell culture constructs remains challenge. Herein, we present an entirely microphysiometry setup that combines needle-type microsensors with motorized sample sensor positioning systems inside standard tissue-culture incubator. The records dissolved oxygen as parameter along...
Melt electrowriting (MEW) is an additive manufacturing (AM) technology with the ability to fabricate complex designs high-resolution. The utility of MEW studied in many fields including tissue engineering and soft robotics. However, current hardware offers only basic functionality often designed built in-house. This affects results replication across different devices slows down technological advancement. To address these issues, we present automated platform real-time process parameter...
To investigate the magnetic properties of different types projectiles and qualify metal artefact reduction technique for diagnostic and/or forensic MRI.Ten embedded in ordnance gelatine blocks underwent an vitro 1.5-T MR study with seven sequences including a recently developed sequence (Advanced WARP) combining VAT (view-angle-tilting) SEMAC (slice-encoding metal-artefact-correction). Resulting image quality (five-point scale: 1=best; 5=worst) was scored. Quantifiable characteristics were...
Augmented reality techniques are being used in clinical medicine and have been suggested for use forensic as well. In this article, we investigate the feasibility of using a head mounted AR display conducting virtual autopsies augmenting autopsy under realistic conditions. For study Microsoft HoloLens (Microsoft Corp., Redmond, USA) augmented device DICOM-Viewer. We conducted 2 phases with 5 participants. phase 1, on PMCT datasets device. 2, participants performed 6 autopsies. The time...
Current mixing steps of viscous materials rely on repetitive and time-consuming tasks which are performed mainly manually in a low throughput mode. These issues represent drawbacks workflows that can ultimately result irreproducibility research findings. Manual-based further limiting the advancement widespread adoption materials, such as hydrogels used for biomedical applications. challenges be overcome by using automated with standardized processes to increase reproducibility. In this...
Screening a newly developed drug, food additive or cosmetic ingredient for toxicity is critical preliminary step before it can move forward in the development pipeline. Due to sometimes dire consequences when harmful agent overlooked, toxicologists work under strict guidelines effectively catalogue and classify new chemical agents. Conventional assays involve long experimental hours many manual steps that increase probability of user error; errors potentially manifest as inaccurate...