A5100620654- Plant Molecular Biology Research
- Knee injuries and reconstruction techniques
- Photosynthetic Processes and Mechanisms
- Wheat and Barley Genetics and Pathology
- Light effects on plants
- Total Knee Arthroplasty Outcomes
- Dialysis and Renal Disease Management
- Radiopharmaceutical Chemistry and Applications
- Mesenchymal stem cell research
- Plant Reproductive Biology
- Pregnancy and preeclampsia studies
- Plant Stress Responses and Tolerance
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Plant Disease Resistance and Genetics
- Cell Adhesion Molecules Research
- Neurogenesis and neuroplasticity mechanisms
- Plant-Microbe Interactions and Immunity
- Crop Yield and Soil Fertility
- Lower Extremity Biomechanics and Pathologies
- Microbial infections and disease research
- Cytomegalovirus and herpesvirus research
- Plant Gene Expression Analysis
- Plant nutrient uptake and metabolism
- CAR-T cell therapy research
Nanjing University of Chinese Medicine
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Huazhong Agricultural University
2018-2025
Parthenope University of Naples
2025
Gansu Agricultural University
2023-2024
Ruijin Hospital
2020-2024
Shanghai Jiao Tong University
2015-2024
Xinjiang Medical University
2024
Shanghai Ninth People's Hospital
2020-2024
The University of Texas Southwestern Medical Center
2019-2023
Carotenoids play important roles in many biological processes, such as light harvesting, photoprotection and visual attraction plants. However, the regulation of carotenoid biosynthesis is still not fully understood. Here, we demonstrate that SlBBX20, a B-box (BBX) zinc-finger transcription factor, positive regulator accumulation tomato (Solanum lycopersicum). Overexpression SlBBX20 leads to dark green fruits leaves higher levels carotenoids relative wild-type. Interactions between...
Abstract The inflorescences and lateral branches of higher plants are generated by meristems. structure the inflorescence has a direct effect on fruit yield in tomato ( Solanum lycopersicum ). We previously demonstrated that miR156a plays important roles determining structures suppressing expression SQUAMOSA PROMOTER BINDING PROTEIN LIKE (SPL) transcription factor gene family. However, information regulatory pathways associated with morphogenesis is still lacking. In this study, we...
Abstract NDH-1 is a key component of the cyclic-electron-transfer around photosystem I (PSI CET) pathway, an important antioxidant mechanism for efficient photosynthesis. Here, we report 3.2-Å-resolution cryo-EM structure ferredoxin (Fd)-NDH-1L complex from cyanobacterium Thermosynechococcus elongatus . The reveals three β-carotene and fifteen lipid molecules in membrane arm NDH-1L. Regulatory oxygenic photosynthesis-specific (OPS) subunits NdhV, NdhS NdhO are close to Fd-binding site whilst...
SignificanceOutside the neurogenic niches, adult brain lacks multipotent progenitor cells. In this study, we performed a series of in vivo screens and reveal that single factor can induce resident astrocytes to become induced neural cells (iNPCs), which then generate neurons, astrocytes, oligodendrocytes. Such conclusion is supported by single-cell RNA sequencing multiple lineage-tracing experiments. Our discovery iNPCs fundamentally important for regenerative medicine since injuries or...
In tomato (Solanum lycopersicum) and other plants, the photoreceptor UV-RESISTANCE LOCUS 8 regulates plant UV-B photomorphogenesis by modulating transcription of many genes, majority which depends on factor ELONGATED HYPOCOTYL 5 (HY5). HY5 is induced then rapidly attenuated UV-B. However, neither factors that activate nor mechanism for its attenuation during signaling known. Here, we report B-BOX (BBX) SlBBX20 SlBBX21 interact with SlHY5 bind to promoter transcription. UV-B-induced...
Light regulates the subcellular localization of plant photoreceptors, a key step in light signaling. Ultraviolet-B radiation (UV-B) induces photoreceptor UV RESISTANCE LOCUS 8 (UVR8) nuclear accumulation, where it photomorphogenesis. However, molecular mechanism for UV-B-regulated UVR8 dynamics is unknown. With fluorescence recovery after photobleaching (FRAP), cell fractionation followed by immunoblotting and co-immunoprecipitation (Co-IP) assays we tested function UVR8-interacting proteins...
The study is to investigate the chondrogenesis of a kind modified cell pellet formed using mesenchymal stem cells (MSCs) and gelatin microspheres containing transforming growth factor β3 (TGF-β3). loaded with TGF-β3 (MS-TGF) were prepared showed controlled release cytokine in biphasic fashion. Then mixture MSCs MS-TGF was centrifuged form pellet. cultured over 4 weeks determine effects on cartilage matrix production by biochemical analysis, immunohistochemistry staining, Western blot test....
We examined the incidence, risk factors, treatments, and clinical outcomes of post-transplantation lymphoproliferative disorder (PTLD) after unmanipulated haploidentical (haplo) hematopoietic stem cell transplantation (HSCT) in 1184 patients between 2006 2012. Age-, time–, duration–matched controls were randomly selected from same cohort. Forty-five experienced PTLD. The median time HSCT to PTLD occurrence was 61 (range, 33 360) days 1-year cumulative incidence total haplo-HSCT 3.0%. In...
The transcription factor ELONGATED HYPOCOTYL5 (HY5) plays critical roles in plant photomorphogenesis. Previous studies on HY5 have mainly focused the seedling stage Arabidopsis (Arabidopsis thaliana), and its functions other species not been well characterized, particularly at adult stages of development. In this report, we investigated tomato (Solanum lycopersicum) (SlHY5) from seedlings to plants with a focus fruits. Genome-edited slhy5 mutants exhibited typical compromised...
CONSTANS (CO) and CONSTANS-LIKE (COL) transcription factors have been known to regulate a series of cellular processes including the transition from vegetative growth flower development in plants. However, their role regulating fruit yield tomato is poorly understood.In this study, ortholog Arabidopsis CONSTANS, SlCOL1, was shown play key roles control yield. Suppression SlCOL1 expression found lead promotion development, resulting increased On contrary, overexpression disturbed...
OPINION article Front. Neurosci., 21 April 2023Sec. Neurogenesis Volume 17 - 2023 | https://doi.org/10.3389/fnins.2023.1181816
As a traditional form of Chinese martial arts, Tai Chi attracts arts enthusiasts worldwide with its unique charm while also serving as an ideal fitness choice for middle-aged and elderly individuals. Its profound philosophy health preservation remarkable benefits make it particularly appealing. emphasizes the coordination breathing movement. Through slow, smooth, coherent, gentle movements, helps regulate physical functions psychological well-being This practice significantly enhances their...
We have recently identified a novel gene, hepaCAM, in liver that encodes cell adhesion molecule of the immunoglobulin superfamily. In this study, we examined characteristics hepaCAM protein and relationship between its structure function, particular adhesive properties. The wild-type cytoplasmic domain-truncated mutants were transfected into human breast carcinoma MCF7 cells, physiological biological properties assessed. Biochemical analyses revealed is an N-linked glycoprotein...
The domestication of tomato has led to striking variations in fruit morphology. Here, we show a genome-wide association study (GWAS) understand the development tip and describe POINTED TIP (PT) gene that encodes C2H2-type zinc finger transcription factor. A single nucleotide polymorphism is found change histidine (H) an arginine (R) C2H2 domain PT two alleles are referred as PTH PTR. Knocking out leads pointed fruit. functions suppress formation by downregulating FRUTFULL 2 (FUL2), which...