A5100381108- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Plant Reproductive Biology
- Plant Stress Responses and Tolerance
- Osteoarthritis Treatment and Mechanisms
- Light effects on plants
- Plant Gene Expression Analysis
- Plant nutrient uptake and metabolism
- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- Acupuncture Treatment Research Studies
- Aerospace and Aviation Technology
- Periodontal Regeneration and Treatments
- Genetics and Neurodevelopmental Disorders
- MicroRNA in disease regulation
- 3D Printing in Biomedical Research
- Tendon Structure and Treatment
- Tissue Engineering and Regenerative Medicine
- Advanced Sensor Technologies Research
- Flow Measurement and Analysis
- Plant Parasitism and Resistance
- Ophthalmology and Visual Impairment Studies
- Studies on Chitinases and Chitosanases
- Thyroid Disorders and Treatments
- Knee injuries and reconstruction techniques
Chinese Academy of Fishery Sciences
2025
Ministry of Education of the People's Republic of China
2022-2024
Chinese Academy of Sciences
2024
Northwest University
2022-2024
Shanghai Jiao Tong University
2018-2023
Sichuan University
2020-2023
State Key Laboratory of Oral Diseases
2020-2023
Shanghai Ninth People's Hospital
2018-2023
Nanjing Medical University
2018-2020
Jiangsu Province Hospital
2018-2020
Congenital hypothyroidism (CH), the most common neonatal metabolic disorder, is characterized by impaired neurodevelopment. Although several candidate genes have been associated with CH, comprehensive screening of causative has limited.One hundred ten patients primary CH were recruited in this study. All exons and exon-intron boundaries 21 for analyzed next-generation sequencing. And inheritance pattern was study family pedigrees.Our results showed that 57 (51.82%) carried biallelic...
The recent advent of 3D bioprinting biopolymers provides a novel method for fabrication tissue-engineered scaffolds and also offers potentially promising avenue in cartilage regeneration. Silk fibroin (SF) is one the most popular used bioprinting, but further application SF hindered by its limited biological activities. Incorporation growth factors (GFs) has been identified as solution to improve function. Platelet-rich plasma (PRP) an autologous resource GFs, which widely clinic. In this...
The spatiotemporal control of meristem identity is critical for determining inflorescence architecture, and thus yield, cereal plants. However, the precise mechanisms underlying spikelet determinacy in cereals are still largely unclear. We have generated loss-of-function overexpression mutants paralogous OsMADS5 OsMADS34 genes rice (Oryza sativa), analysed their panicle phenotypes. Using chromatin immunoprecipitation, electrophoretic mobility-shift dual-luciferase assays, we also identified...
Significance The transcription factor FAR-RED ELONGATED HYPOCOTYL3 ( FHY3 ) is known to play multiple roles at the vegetative stage in Arabidopsis , but its functions reproductive are unclear. We find that required for floral meristem determinacy and shoot apical maintenance by mainly acting as a transcriptional repressor. mediates light-regulated CLAVATA3 expression regulate WUSCHEL directly represses activates SEPALLATA2 promote determinacy. Furthermore, may coregulate flower development...
Soil salinization is one of the most crucial abiotic stresses that limit growth and production eggplant. The existing researches in eggplant were mostly focused on salt-induced morphological, biochemical physiological changes, with only limited works centered salt-response genes at transcriptomic level.Our preliminary work found Zhusiqie (No.118) salt-tolerant Hongqie (No.30) salt-sensitive. Consequently, they re-named as ST118 SS30, respectively. showed less damaged higher K+/Na+ ratios...
Articular cartilage, composed of collagen type II as a major extracellular matrix and chondrocyte unique cell type, is specialized connective tissue without blood vessels, lymphatic vessels nerves. This distinctive characteristic articular cartilage determines its very limited ability to repair when damaged. It well known that physical microenvironmental signals regulate many behaviors such morphology, adhesion, proliferation communication even determine fate. Interestingly, with increasing...
The exquisite cartilage architecture maintains an orderly dynamic equilibrium as a result of the interplay between chondrocyte functions and unique extracellular matrix (ECM) microenvironment. Numerous studies have demonstrated that cues, including topological, mechanical, biochemical properties underlying substrates, dictate behaviors. Consequently, developing advanced biomaterials with desired characteristics which could achieve biointerface cells surrounded close to physiological...
Bioactive scaffolds are used in cartilage regeneration for providing an environment conducive to chondrogenic differentiation and proliferation of stem cells vitro vivo. This study aimed develop a composite scaffold comprising silk fibroin (SF) extracellular matrix (ECM), which could not only preserve the biological activity original ECM, promotes bone marrow-derived mesenchymal (BMSCs), but also provide great mechanical strength. To this end, we manufactured containing different ratios SF...
The architecture of inflorescence and the development floral organs can influence yield seeds have a significant impact on plant propagation. E-class homeotic MADS-box genes exhibit important roles in regulation transition differentiation organs. Woad (Isatis indigotica) possesses unique inflorescence, fruit. However, very little research has been carried out to determine function this medicinal cruciferous species.SEPALLATA orthologs I. indigotica were cloned by degenerate PCR. sequence...
Summary Organ size is determined mainly by cell division and expansion. Several genetic factors regulating development of plant lateral organs have been characterized, but those involved in determining reproductive organ separation rice ( Oryza sativa ) remain unknown. We isolated the gene SMALL REPRODUCTIVE ORGANS SRO encoding a nucleus‐localized Cys2His2 (C 2 H zinc finger protein orthologous to Arabidopsis transcription factor (TF) SUPERMAN (SUP). Combined developmental, genetic,...
Abstract The pathogenesis of thyroid dysgenesis (TD) is not well understood. Here, using a combination single-cell RNA and spatial transcriptome sequencing, we identify subgroup NF-κB-activated thyrocytes located at the center tissues in postnatal mice, which maintained partially mesenchymal phenotype. These cells actively protruded out primordium generated new follicles zebrafish embryos through continuous tracing. Suppressing NF-κB signaling affected thyrocyte migration follicle formation,...
Accurate perception of flow data in flight is critical for the navigation, guidance, and control aircraft. Flush Air Data Sensing (FADS) a new type non-intrusive sensing technology that mainly uses distributed pressure sensors on surface an aircraft to indirectly sense parameters without deployment mechanisms. For wide-speed range air measurement, this research constructs multi-physical parameter system based dimensionless input-output neural network model. The combined with data-driven...