A5101712904- Tendon Structure and Treatment
- Bone and Joint Diseases
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Hip disorders and treatments
- Sports injuries and prevention
- Shoulder Injury and Treatment
- Laser Applications in Dentistry and Medicine
- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Spine and Intervertebral Disc Pathology
- Spinal Cord Injury Research
- Medical Imaging and Analysis
- Musculoskeletal pain and rehabilitation
- Orthopedic Infections and Treatments
- Tissue Engineering and Regenerative Medicine
- Neurogenesis and neuroplasticity mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Nerve injury and regeneration
- Myofascial pain diagnosis and treatment
- Electrospun Nanofibers in Biomedical Applications
- Connective tissue disorders research
- Mesenchymal stem cell research
- Congenital heart defects research
- Marine Biology and Environmental Chemistry
Guangdong Academy of Medical Sciences
2011-2025
Guangdong Provincial People's Hospital
2006-2025
Southern Medical University
2022-2025
The First Affiliated Hospital, Sun Yat-sen University
2023
Sun Yat-sen University
2023
Guangdong General Hospital
2010-2021
South China University of Technology
2019-2020
The University of Western Australia
2020
West China Medical Center of Sichuan University
1996
Identification of functional programmable mechanical stimulation (PMS) on tendon not only provides the insight homeostasis under physical/pathological condition, but also guides a better engineering strategy for regeneration. The aims study are to design bioreactor system with PMS mimic in vivo loading conditions, and define impact different cyclic tensile strain tendon. Rabbit Achilles tendons were loaded with/without (0.25 Hz 8 h/day, 0-9% 6 days). Tendons without lost its structure...
The selection of a suitable scaffold matrix is critical for cell-based bone tissue engineering.This study aimed to identify and characterize natural marine sponges as potential bioscaffolds osteogenesis.Callyspongiidae sponge samples were collected from the Fremantle coast Western Australia.The structure was assessed using scanning electron microscopy (SEM) Hematoxylin eosin.Mouse primary osteoblasts seeded onto immunostained with F-actin assess cell attachment aggregation.Alkaline...
Abstract Introduction Avascular necrosis of femoral head (ANFH) is a progressive disease that often leads to hip joint dysfunction and even disability in young patients. Although the standard treatment, which core decompression, has advantage minimal invasion, efficacy variable. Recent studies have shown implantation bone marrow containing osteogenic precursors into necrotic lesion ANFH may be promising for treatment ANFH. Methods A prospective, double-blinded, randomized controlled trial...
Neuromuscular diseases usually manifest as abnormalities involving motor neurons, neuromuscular junctions, and skeletal muscle (SkM) in postnatal stage. Present vitro models of interactions require a long time lack neuroglia involvement. Our study aimed to construct rodent bioengineered spinal cord neural network-skeletal (NN-SkM) assembloids elucidate the between stem cells (SC-NSCs) SkM their biological effects on development maturation circuits. After coculture with cells, SC-NSCs...
The tendon is a mechanosensitive tissue, but little known about how mechanical stimulation selectively signals tenogenic differentiation and neo-tendon formation. In this study, we compared the impact of uniaxial biaxial loading on tendon-derived stem cells (TDSCs). Our data show that there are variations in cell signaling mouse TDSCs response to monolayer culture. Whereas induced toward osteogenic differentiation, osteogenic, adipogenic, chondrogenic TDSCs. Furthermore, by applying...
Physiotherapy is one of the effective treatments for tendinopathy, whereby symptoms are relieved by changing biomechanical environment pathological tendon. However, underlying mechanism remains unclear. In this study, we first established a model progressive tendinopathy-like degeneration in rabbit Achilles. Following ex vivo loading deprivation culture bioreactor system 6 and 12 days, tendons exhibited degenerative changes, abnormal collagen type III production, increased cell apoptosis,...
Abstract Tendinopathy is one of the most common musculoskeletal diseases, and mechanical overload considered its primary cause. However, underlying mechanism through which induces tendinopathy has not been determined. In this study, we identified for first time that tendon cells can release extracellular mitochondria (ExtraMito) particles, a subtype medium particles (mEPs), into environment process regulated by loading. RNA sequencing systematically revealed oxygen-related reactions,...
The extracellular matrix protein SPARC modulates load sensing in tendons and is critical for tissue maturation homeostasis.
After spinal cord injury (SCI), endogenous neural stem cells are activated and migrate to the site where they differentiate into astrocytes, but rarely neurons. It is difficult for brain-derived information be transmitted through after SCI because of lack neurons that can relay site, functional recovery adult mammals achieve. The development bioactive materials, tissue engineering, cell therapy, physiotherapy has provided new strategies treatment shown broad application prospects, such as...
Botulinum toxin (Botox) injection is in widespread clinical use for the treatment of muscle spasms and tendinopathy but mechanism action poorly understood. We hypothesised that reduction patellar-tendon mechanical-loading following intra-muscular Botox results tendon atrophy at least part mediated by induction senescence tendon-derived stem cells (TDSCs). Controlled laboratory study METHODS: A total 36 mice were randomly divided into 2 groups (18 Botox-injected 18 vehicle-only control). Mice...
Abstract Background Treatment of avascular necrosis the femoral head (ANFH) in young patients remains a clinical challenge. A current controversy is whether hip-preserving surgery results better outcomes. The adverse effects are associated with fill material for necrotic areas. This study aims to evaluate early autologous bone marrow buffy coat (BBC) and angioconductive bioceramic rod (ABR) grafting advanced core decompression (ACD) on ANFH. Methods Forty-four (57 hips) ANFH from 2015 2020...
Tendons are the force transferring tissue that enable joint movement. Excessive mechanical loading is commonly considered as a primary factor causing tendinopathy, however, an increasing body of evidence supports hypothesis overloading creates microdamage collagen fibers resulting in localized decreased on cell population within damaged site. Heterotopic ossification complication late stage which can significantly affect properties and homeostasis tendon. Here, we examine effect underloading...
Abstract Background Femoral neck fractures in elderly patients typically warrant operative treatment and are related to high risks of mortality morbidity. As early hip arthroplasties for femoral widely accepted, rapid predicting models that allowed quantitative individualized prognosis assessments strongly needed as references orthopedic surgeons during preoperative conversations. Methods Data aged ≥ 65 years old who underwent primary unilateral hemiarthroplasty or total arthroplasty due...
To determine the repair of LMPR lesions would improve ACL graft maturation.A total 49 patients underwent reconstruction were included in this study. Patients furtherly sub-grouped according to status LMPR: intact (17), (16) and resected (16). Assessments performed pre- 2 years post-operatively patients-reported scores arthrometer side-to-side difference. Magnetic resonance imaging was used after surgery compare lateral meniscal extrusion (LME), anterior tibial subluxation medial compartment...