A5101553913- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Total Knee Arthroplasty Outcomes
- Bone and Joint Diseases
- Osteoarthritis Treatment and Mechanisms
- Hip and Femur Fractures
- Cardiac, Anesthesia and Surgical Outcomes
- Liver Diseases and Immunity
- Knee injuries and reconstruction techniques
- Renal Transplantation Outcomes and Treatments
- Bone Metabolism and Diseases
- Organ Transplantation Techniques and Outcomes
- Mesenchymal stem cell research
- Rheumatoid Arthritis Research and Therapies
- Periodontal Regeneration and Treatments
- Bone health and osteoporosis research
- Electrospun Nanofibers in Biomedical Applications
- Transplantation: Methods and Outcomes
- Galectins and Cancer Biology
- Spondyloarthritis Studies and Treatments
- MicroRNA in disease regulation
- Immune cells in cancer
- Hepatitis B Virus Studies
- Shoulder Injury and Treatment
Guangdong Academy of Medical Sciences
2014-2025
Guangdong Provincial People's Hospital
2011-2025
Sun Yat-sen University
2024-2025
Southern Medical University
2023-2025
South China University of Technology
2019-2020
Guangdong General Hospital
2014-2020
King's College Hospital
1992-2015
King's College London
2015
St Mark's Hospital
2004
University College London
1998
Abstract Introduction Avascular necrosis of femoral head (ANFH) is a progressive disease that often leads to hip joint dysfunction and even disability in young patients. Although the standard treatment, which core decompression, has advantage minimal invasion, efficacy variable. Recent studies have shown implantation bone marrow containing osteogenic precursors into necrotic lesion ANFH may be promising for treatment ANFH. Methods A prospective, double-blinded, randomized controlled trial...
Abstract Introduction Ankylosing spondylitis (AS) is a chronic autoimmune disease, and the precise pathogenesis largely unknown at present. Bone marrow-derived mesenchymal stem cells (BMSCs) with immunosuppressive anti-inflammatory potential Th17/Treg reciprocal relationship regulated by BMSCs have been reported to be involved in some disorders. Here we studied biological immunological characteristics of BMSCs, frequency phenotype CCR4 + CCR6 Th/Treg their interaction vitro AS. Methods The...
Abstract Human adipose‐derived stem cells (hADSC) are capable of differentiating into an osteogenic lineage. It is believed that microRNAs (miRNAs) play important roles in regulating this differentiation human cells, although its molecular mechanism remains unclear. We investigated the miRNA expression profile during hADSCs, and assessed involved miRNAs differentiation. obtained cultured stems from donors who underwent elective liposuction or other abdominal surgery at our institution....
Vitamin D deficiency is a common comorbidity in geriatric hip fracture patients. However, there still an ongoing debate regarding the influence of preoperative status on postoperative mortality patients.Elderly patients (≥60 years) who underwent surgical interventions for unilateral from 2015 to 2020 our center were included. We retrospectively retrieved demographic data electronic medical database. Preoperative serum total 25-hydroxy-Vitamin was set as independent variable and classified...
Immunological mechanisms play a vital role in the pathogenesis of knee osteoarthritis (KOA). Moreover, immune phenotype is relevant prognostic factor various immune-related diseases. In this study, we used CIBERSORT for deconvolution global gene expression data to define cell landscape different structures osteoarthritis. Methods and Findings. By applying CIBERSORT, assessed relative proportions cells 76 samples cartilage, 146 synovial tissue, 40 meniscus, 50 subchondral bone. Enumeration...
The peritoneum is a common site of metastasis in gastric cancer (GC), associated with poor prognosis and significant morbidity. proclivity GCs to metastasize the has been hypothesized occur due latter's immunosuppressive microenvironment, such as stromal infiltration M2 macrophage enrichment, which are increased risk PM. As far we know, model that can effectively predict patients GCPM still lacking. Consequently, constructed prognostic based on macrophages peritoneal metastasis, aiming...
Background: Primary biliary cirrhosis (PBC) is an immune‐mediated chronic cholestatic disease characterized by the presence of antibodies directed predominantly against E2 subunit pyruvate dehydrogenase complex (PDC‐E2). What provokes tolerance breakdown in PBC remains to be established, though there evidence indicate that microbes may induce anti‐mitochondrial (AMA) through a mechanism molecular mimicry. Methods: Having found urease beta (UREB) 22–36 antigen Helicobacter pylori (HELPY)...
Abstract Background Avascular necrosis of the femoral head (ANFH) is a severely disabling disease hip. Several clinical trials have shown promising outcomes on use mesenchymal stem cells for treatment ANFH, but long-term assessments are lacking. Previously, we reported 2-year follow-up results prospective, double-blinded, randomized, controlled study autologous bone marrow buffy coat grafting combined with core decompression in patients ANFH. Here, report 10-year this study. Methods We...
Our study demonstrated wear particles, which are generated by the abrasion of implanted prostheses, could induced STAT3 activation in osteoblasts. And further, inflammatory responses and RANKL expression would activate osteoclasts cause osteolysis.
Transthoracic echocardiography (TTE) is a common cardiac screening test before hip fracture surgery. However, the general TTE delays surgery, so it would be meaningful if we could simplify by only assessing abnormality specifically. Therefore, aimed to establish most clinically relevant comparing predictive value of each major in postoperative complications and mortality elderly patients.From January 2014 2019, medical records all surgically treated patients (>65 years) with were analyzed....
Abstract Background Treatment of avascular necrosis the femoral head (ANFH) in young patients remains a clinical challenge. A current controversy is whether hip-preserving surgery results better outcomes. The adverse effects are associated with fill material for necrotic areas. This study aims to evaluate early autologous bone marrow buffy coat (BBC) and angioconductive bioceramic rod (ABR) grafting advanced core decompression (ACD) on ANFH. Methods Forty-four (57 hips) ANFH from 2015 2020...
Osteoarthritis (OA) is a degenerative disease that affects millions of individuals worldwide. Despite its prevalence, the exact causes and mechanisms behind OA are still not fully understood, resulting in lack effective treatments to slow down or halt progression. Recent research has discovered extracellular vesicles (EVs) present circulation young mice have remarkable ability activate musculoskeletal stem cells elderly mice. Conversely, EVs derived from do exhibit same potential, indicating...
Revision total hip arthroplasty (THA) with large acetabular defect remains a challenge. Though trabecular metal (TM) cup and augments have been introduced in reconstruction good result, the accurate positioning of implant is important to avoid complications. Therefore, we aimed evaluate usefulness three-dimensional (3D) simulation 3D model assisting during complex revision THA.Sixteen patients (18 hips) who underwent THA Paprosky type III were analyzed retrospectively. Placement TM was...
To compare the effects of peripheral nerve block (PNB) and spinal anesthesia (SA) on one-year mortality walking ability elderly hip fracture patients after arthroplasty.Patients ≥65 years who underwent unilateral arthroplasty due to femoral neck fracture, using either PNB or SA from 2014 2019, were included. Demographic data, comorbidities, results preoperative screening retrospectively collected. Propensity score matching (PSM) was performed in a ratio 1:1 for groups. The primary outcomes...
Abstract Background Femoral neck fractures in elderly patients typically warrant operative treatment and are related to high risks of mortality morbidity. As early hip arthroplasties for femoral widely accepted, rapid predicting models that allowed quantitative individualized prognosis assessments strongly needed as references orthopedic surgeons during preoperative conversations. Methods Data aged ≥ 65 years old who underwent primary unilateral hemiarthroplasty or total arthroplasty due...