A5101737457- MicroRNA in disease regulation
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- Pluripotent Stem Cells Research
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- Spectroscopy Techniques in Biomedical and Chemical Research
- Molecular Biology Techniques and Applications
- T-cell and Retrovirus Studies
- Advanced Chemical Sensor Technologies
- Colorectal and Anal Carcinomas
- RNA Research and Splicing
- Vector-Borne Animal Diseases
- Metabolomics and Mass Spectrometry Studies
- Endometrial and Cervical Cancer Treatments
- Hematopoietic Stem Cell Transplantation
- NF-κB Signaling Pathways
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Tea Polyphenols and Effects
Sun Yat-sen University
2022-2025
Fujian Medical University
2008-2024
Jiangsu Hengrui Medicine (China)
2024
Guizhou Academy of Agricultural Sciences
2024
Tea Research Institute
2024
First Affiliated Hospital of Fujian Medical University
2024
Union Hospital
2006-2022
Third Affiliated Hospital of Sun Yat-sen University
2022
Sichuan University
2018
Nanjing University
2016
Abstract Circulating microRNAs (miRNAs) are emerging biomarkers for type 2 diabetes mellitus (T2DM). However, a comprehensive characterization of the serum miRNA profile in patients with T2DM-associated microvascular disease (T2DMC) has rarely been reported. In this study, we obtained samples from 184 T2DM (92 complications and 92 free complications) age/gender-matched controls. The levels 754 miRNAs were initially analyzed using TaqMan Low Density Array (TLDA) three pooled 24 patients,...
The levels of miR-93, miR-191, and miR-499 have been reported to be up-regulated in the tissues experimental traumatic brain injury (TBI) rat models. However, clinical diagnostic prognostic values serum signatures these 3 miRNAs TBI remain unclear. purpose this study was determine expression microRNAs (miRNAs) sera patients evaluate their relationships with severity outcome TBI. were assessed (n = 76) healthy controls 38) by quantitative reverse-transcription PCR. severities outcomes...
Ancient tea plants black (ATBT) has outstanding sweet-mellow taste, but what contributes to its quality remains unclear. We tested 36 freeze and 9 finished sampled from five processing stages for ATBT by electronic tongue (ET), high performance liquid chromatography, gas chromatography-tandem mass spectrometry. ET chromatographic data revealed variation of sensory characteristics chemical compounds among the steps ATBT. Through correlation analysis principal component analysis, it was...
The peritoneum is a common site of metastasis in gastric cancer (GC), associated with poor prognosis and significant morbidity. proclivity GCs to metastasize the has been hypothesized occur due latter's immunosuppressive microenvironment, such as stromal infiltration M2 macrophage enrichment, which are increased risk PM. As far we know, model that can effectively predict patients GCPM still lacking. Consequently, constructed prognostic based on macrophages peritoneal metastasis, aiming...
HLA‐C*07:1089 differs from HLA‐C*07:02:01:01 by one nucleotide in exon 3.
// Yan-Ling Zeng 1, 2, * , Hao Zheng Qiu-Ru Chen Xiao-Hong Yuan 1 Jin-Hua Ren Xiao-Feng Luo Ping Zhe-Yao Lin 2 Shao-Zhen Xue-Qiong Wu Min Xiao Yong-Quan Zhi-Zhe Jian-Da Hu Ting Yang Department of Hematology, Fujian Institute Provincial Key Laboratory Medical University Union Hospital, Fuzhou 350001, P. R. China Affiliated Nanping First Hospital University, 353000, These authors are regarded as co-first author Correspondence to: Yang, email: yang.hopeting@gmail.com Hu, drjiandahu@163.com...
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by complex molecular and cytogenetic abnormalities. New approaches to predict the prognosis of AML have increasingly attracted attention. There were 98 non-M3 cases 48 healthy controls enrolled in current work. Clinically routine assays for genetic analyses performed on bone marrow samples patients with AML. Meanwhile, metabolic profiling these subjects was also serum combining Ag nanoparticle-based surface-enhanced Raman...
Abstract T cell acute lymphoblastic leukaemia (T‐ALL) is a highly aggressive haematological cancer of the bone marrow. The abnormal expression microRNAs (miRNAs) reportedly involved in T‐ALL development and progression. Thus, we aimed to decipher involvement miR‐204 silencing mediated by DNA methylation occurrence (T‐ALL). was determined marrow peripheral blood samples from patients real‐time quantitative PCR (RT‐qPCR) with its effect on proliferation evaluated functional assays. In...
The combination of anti-programmed death 1 (PD-1) inhibitors and tyrosine kinase is an effective treatment strategy in endometrial cancer. We aimed to explore the efficacy safety camrelizumab plus apatinib as alternative therapeutic option patients with previously treated This single-arm Simon's two-stage phase II trial was conducted at Fudan University Shanghai Cancer Center. Patients advanced or recurrent cancer who had failed least one prior systemic therapy were screened for potential...
CD40/CD40L interaction on high-grade aggressive lymphomas such as Burkitt lymphoma results in a decrease proliferation, whereas transient increase proliferation and survival vitro is seen with indolent lymphomas. In this study, cell growth inhibition human lines CA46 Raji were obtained either srhCD40L or pyrrolidine dithiocarbamate (PDTC), specific inhibitor of NF-kappaB, converse effects CD40 negative control. Moreover, S phase arrest was demonstrated cells the presence srhCD40L, also...
Background: Dysregulation of RNA-binding proteins (RBPs) in cancers is associated with immune and cancer development. Here, we aimed to profile immune-related RBPs lung adenocarcinoma (LUAD) construct an RBP signature (IRBPS) predict the survival response immunotherapy. Methods: A correlation analysis was performed establish a co-expression network genes (IRGs) characterize TCGA-LUAD cohort (n = 497 cases). Then, combination Random forest (RSF) Cox regression screen IRBPS. This followed by...
Multidrug resistance is highly associated with poor prognosis of chronic myeloid leukemia. This work aims to explore whether the laser tweezers Raman spectroscopy (LTRS) could be practical in separating adriamycin-resistant leukemia cells K562/adriamycin from its parental K562, and potential mechanisms. Detection LTRS initially reflected spectral differences caused by chemoresistance including bands assigned carbohydrates, amino acid, protein, lipids, nucleic acid. In addition, principal...
To explore the association between UCP2 rs659366 polymorphisms and outcomes of patients after surgery for colorectal cancer.The study was conducted among a cohort 501 with primary cancer who had in Sichuan Cancer Hospital during March 2010 July 2013. The were followed up. polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method applied to detect UPC2 genotypes. log-rank test performed analyze effects clinical features on patients' outcomes. correlation analyzed...
Busulfan is a bifunctional alkylating agent that widely used before hematopoietic stem cell transplantation (HSCT), in combination with other chemotherapeutic drugs. As of 2020, there no population pharmacokinetic (popPK) model for busulfan Chinese pediatric patients. A systemic external evaluation 11 published popPK models was conducted patients undergoing HSCT. Forty were enrolled this study, total 183 blood concentrations. The relative prediction error (PE%), median PE%, absolute and...
Induced pluripotent stem (iPS) cell based on recently developed reprogramming technique holds great hope for regenerative medicine,in vitro disease modeling and drug evaluation.Recent progress clinical hematology includes in generation of hematopoietic progenitors mature blood cells from somatic cells,iPS derived chronic myeloid leukemia the better understanding resistance mechanisms bcr-abl inhibitor imatinib,and moreover,correction monogenic inherited using gene-targeted...