A5061900185- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Pluripotent Stem Cells Research
- Mesenchymal stem cell research
- Cell Adhesion Molecules Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Protein Degradation and Inhibitors
- Circular RNAs in diseases
- Multiple Myeloma Research and Treatments
- Cancer Mechanisms and Therapy
- Pharmacological Effects and Toxicity Studies
- Hepatitis B Virus Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Antimicrobial Peptides and Activities
- Retinoids in leukemia and cellular processes
- Research on Leishmaniasis Studies
Jilin University
2025
State Key Laboratory of Superhard Materials
2025
Fujian Medical University
2013-2024
Union Hospital
2013-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2019
Yangzhou University
2012
Ningbo University
2009-2010
Ningbo Medical Center Lihuili Hospital
2009-2010
The aim of this study was to identify the changes hematologic and immunological parameters in COVID-19 patients. We collected analyzed data 117 patients who were laboratory confirmed as SARS-CoV-2 infection. cases divided into regular group, severe group critically ill according sixth edition scheme for diagnosis treatment China. tests included blood routine, cellular humoral immunity indices, biochemical detections inflammatory biomarker. Compared with patients, had significantly lower...
Hexagonal diamond (HD) was reported 60 years ago and has attracted extensive attention owing to its ultrahigh theoretical hardness, 58% superior cubic counterpart. However, date, synthesizing pure HD under high-pressure high-temperature (HPHT) remains unsuccessful due the limitations of understanding formation mechanism. In this work, employing a systematic molecular dynamics simulation, we directly observe graphite-to-HD transition in nucleation-growth Specifically, is formed quasi-uniaxial...
The increasing genomic complexity of acute myeloid leukemia (AML), the most common form leukemia, poses a major challenge to its therapy. To identify potent therapeutic targets with ability block multiple cancer-driving pathways is thus imperative. unique peptidyl-prolyl cis-trans isomerase Pin1 has been reported promote tumorigenesis through upregulation numerous pathways. Although key drug target for treating promyelocytic (APL) caused by fusion oncogene, much less known about role in...
At present, it is generally believed that leukemia stem cells are the source of AML, so killing has become important. Previous studies have suggested HHT combined with ATO can synergistically kill U937 cells, and also demonstrated ability to cells. We evaluated whether systematically (LSCs) explored synergistic effect molecular mechanism.CCK-8 was used detect cell viability. The changes cycle (PI staining), apoptosis (Annexin V/PI) surface markers (CD34, CD38, CD96, CD45) were detected by...
// Yan-Ling Zeng 1, 2, * , Hao Zheng Qiu-Ru Chen Xiao-Hong Yuan 1 Jin-Hua Ren Xiao-Feng Luo Ping Zhe-Yao Lin 2 Shao-Zhen Xue-Qiong Wu Min Xiao Yong-Quan Zhi-Zhe Jian-Da Hu Ting Yang Department of Hematology, Fujian Institute Provincial Key Laboratory Medical University Union Hospital, Fuzhou 350001, P. R. China Affiliated Nanping First Hospital University, 353000, These authors are regarded as co-first author Correspondence to: Yang, email: yang.hopeting@gmail.com Hu, drjiandahu@163.com...
Summary There are several reports describing population pharmacokinetic (pop PK ) models of busulfan ( BU ). However, limited information is available in Chinese hematopoietic stem cell transplantation HSCT patients. The present study aimed to establish a pop model intravenous patients for individualized drug therapy. was developed from total 284 concentration–time points 53 effects demographic and biochemical covariates were investigated by nonlinear mixed effect NONMEM software. Plots,...
The present study aimed to establish an induced pluripotent stem cell (iPSC) line from acute myelogenous leukemia (AML) cells in vitro and identify their biological characteristics.Cells the AML-infiltrated skin M6 patient were infected with a lentivirus carrying OCT4, SOX2, KLF4 C-MYC induce iPSCs. characteristics of iPSCs confirmed by alkaline phosphatase (ALP) staining. proliferation ability was detected CCK-8 assay. expression pluripotency markers measured immunostaining, cell-related...
Bone marrow mesenchymal stem cells (BMSCs) have been extensively investigated from a perspective on cardiac regeneration therapy. The current study aimed to investigate the protective effect conferred by BMSCs in subacute myocardial injury, and identify an appropriate BMSC reinfusion time.BMSCs were isolated human bone blood. Daunorubicin (DNR)-induced models subsequently established. rats with DNR-induced injury injected dexrazoxane (DZR) and/or at varying time points, after which function...
Objective: To analyze the prevalence of influenza A/B in preschool children and neutrophils to lymphocytes ratio (NLR) positive patients with influenza-like illness, order provide more ideas basis for prevention, diagnosis treatment illness. Methods: Children who were not than 6 years old, screened antigen viruses Second Affiliated Hospital Xi'an Jiaotong University, enrolled this study from November 2017 February 2018. The venous blood or finger tip participants collected routine test. SPSS...
Haplo-HSCT has been used when HLA-matched siblings are not available. Conditioning regimens aim to reduce tumor burden prior HSCT and provide sufficient immunoablation. We report the outcome of haplo-HSCT in 63 consecutive patients from 2/2013 12/2015 (19 females/44 males) with high-risk or relapsed/refractory hematological malignancies (n=29-AML; 8-sAML; 19-ALL; 5-advanced-MDS; 2-CML-BC). Median age was 20 years (range: 1.1-49). Twenty-one achieved remission transplant, while 42 did not....
The value of plasma fibronectin (pFN) in the diagnosis and prognosis sepsis has not been fully established. Previous studies finding that pFN is significantly reduced sepsis, however, whether pFn affects clarified. Here, we detected analyzed other conventional inflammatory markers advanced patients performed correlation analysis with SOFA score. We also used Fn gene conditional knockout mice which were by cecum ligation puncture (CLP) to investigate effect FN deficiency on prognosis. found,...
Fibronectin (FN) is a multi-functional glycoprotein that primarily acts as cell adhesion molecule and tethers cells to the extra cellular matrix. In order clarify effect of FN deficiency on hematopoiesis, biochemical immune parameters in mice. We constructed tamoxifen-induced conditional (cre-loxp system) fibronectin knock-out (FnKO) mouse model C57BL/6 background, monitored their behavior, fertility, histological, hematopoietic, immunological indices. found Fn KO mice had reduced high...
<title>Abstract</title> <bold>Background: </bold>Comparative data on the efficacy and safety of tandem or single autologous stem cell transplantation (ASCT) for patients with multiple myeloma (MM) in China are currently lacking. This study aimed to compare clinical outcomes ASCT real-world MM patients. <bold>Methods:</bold> By utilizing a propensity score, we retrospectively analyzed 80 newly diagnosed who underwent our center between November 2014 2021, 40 each group receiving either ASCT....
Relapse remains the main cause of treatment failure in patients with myeloid malignancies even after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We observed a particularly low incidence relapse prepared fludarabine, busulfan and melphalan our previous study this multicenter retrospective analysis aimed to confirm feasibility regimen identify potential prognostic factors. This was performed using registry data from adults who underwent their first allo-HSCT following...
Background Autologous stem cell transplantation (ASCT) is a potentially curative strategy for relapse or refractory(r/r) aggressive lymphoma. However, proportion of lymphoma patients who are at high risk mobilization failure fail to mobilize cells and cannot proceed ASCT. The aim this study explore the efficacy safety Etoposide combined with Cytarabine (EA) plus G-CSF in poor mobilizers (PMs) r/r Methods This retrospective analyzed outcomes chemo-mobilization based on EA (Etoposide 0.1 g/m2,...
To investigate the effect and possible mechanism of low concentration triptolide (TPL) combined with homoharringtonine (HHT) on proliferation apoptosis KG-1α cells.CCK-8 method was used to detect antiproliferating effects different concentrations TPL HHT single-use use cells, index (CI) calculated. The colony formation ability also determined by methylcellulose assay, cell surface molecules, rate cycle changes were detected flow cytometry. Westerrn blot expression Akt signaling pathway...
To evaluate cyclosporine A (CSA)-related neurotoxicity after haploidentical hematopoietic stem cell transplantation (HID-HSCT) in children with hematopathy.This retrospective case series study included hematopathy who underwent HID-HSCT at Fujian Medical University Union Hospital between February 2013 and January 2017.Fifty-one (39 males) were the a median age of 8 (range, 1.1-18) years. Seven patients (13.7%) developed CSA-related 38 - 3 to 161) days from HID-HSCT. Hypertension (5/7, 71%)...