A5100729598- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Cancer Genomics and Diagnostics
- Antimicrobial Resistance in Staphylococcus
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Pregnancy and preeclampsia studies
- Sarcoma Diagnosis and Treatment
- Traditional Chinese Medicine Studies
- Hepatitis B Virus Studies
- Cholesterol and Lipid Metabolism
- Cardiovascular Disease and Adiposity
- Hormonal Regulation and Hypertension
- Drug Transport and Resistance Mechanisms
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hepatitis C virus research
- Circular RNAs in diseases
- CAR-T cell therapy research
- Bacterial biofilms and quorum sensing
- Gestational Diabetes Research and Management
- Environmental Changes in China
- Heme Oxygenase-1 and Carbon Monoxide
- Traditional Chinese Medicine Analysis
- RNA modifications and cancer
- Infective Endocarditis Diagnosis and Management
Nanjing Medical University
2015-2024
Fujian Medical University
2024
Weatherford College
2024
Peking University Shenzhen Hospital
2020-2024
State Key Laboratory of Natural Medicine
2022
Nanjing Drum Tower Hospital
2019-2021
ShenZhen People’s Hospital
2021
Shenzhen University
2020-2021
Guangdong Medical College
2015-2021
Henan University
2021
Acyl-CoA:cholesterol acyltransferase (ACAT) catalyzes esterification of cellular cholesterol. To investigate the role ACAT-1 in atherosclerosis, we have generated null (ACAT-1−/−) mice. ACAT activities were present liver and intestine but completely absent adrenal, testes, ovaries, peritoneal macrophages our ACAT-1−/− The mice had decreased openings eyes because atrophy meibomian glands, a modified form sebaceous glands normally expressing high activities. This phenotype is similar to dry...
The interdependence of cell cycle control, chromatin remodeling and fate determination remains unclear in flowering plants. Pollen development provides an interesting model, as it comprises only two types produced by sequential divisions. first division separates the vegetative from generative cell. divides produces sperm cells, transported to female gametes pollen tube We show Arabidopsis thaliana that loss activity Chromatin assembly factor 1 (CAF1) pathway causes delay arrest during...
Squalene synthase (SS) catalyzes the reductive head-to-head condensation of two molecules farnesyl diphosphate to form squalene, first specific intermediate in cholesterol biosynthetic pathway. We used gene targeting knock out mouse SS gene. The mice heterozygous for mutation (<i>SS+/−</i>) were apparently normal. <i>SS+/−</i> showed 60% reduction hepatic mRNA levels compared with <i>SS+/+</i> mice. Consistently, enzymatic activities reduced by 50% liver and testis. Nevertheless, synthesis...
Lipoprotein lipase (LPL) is known to play a crucial role in lipoprotein metabolism by hydrolyzing triglycerides; however its atherogenesis has yet be determined. We have previously shown that low density receptor knockout mice overexpressing LPL are resistant diet-induced atherosclerosis due the suppression of remnant lipoproteins. Plasma lipoproteins and apolipoprotein (apo) E which overexpress human transgene (LPL/APOEKO) were compared with those control apoE (APOEKO). On normal chow diet,...
The risk factors mostly strongly associated with gastric cancer are bacteria Helicobacter pylori and diet. Using a case-control study among residents in Jinan, we examined the association between salt taste according to H. infection, smoking histological type as well tumor site.This population-based included 207 cases 410 controls. Data on potential of were obtained by interview controls questionnaire, preference was measured for all subjects, IgG antibodies applied assess infection. Risk...
Abstract Circular RNA (circRNA) is a novel member of endogenous noncoding RNAs with widespread distribution and diverse cellular functions. Recently, circRNAs have been identified for their enrichment stability in exosomes. However, the roles from umbilical cord blood exosomes gestational diabetes mellitus (GDM) occurrence fetus growth remains poorly understood. In present study, we used microarray technology to construct comparative circRNA profiling between GDM patients controls. We found...
We aimed to determine prognostic indicators of PE patients with hemodynamic decompensation admitted the ICU. at ICU admission from Medical Information Mart for Intensive Care IV database were included. Least absolute shrinkage and selection operator 2 specific lambdas performed reduce dimension variables after univariate analysis. Then we conducted multivariate logistic regression analysis models built. A total 548 included, among whom 187 died. Lactate, creatine-kinase MB, troponin-T...
Introduction: New genetic variants associated with susceptibility to obesity and metabolic diseases have been discovered in recent genome-wide association (GWA) studies. The aim of this study was investigate the theses risk gestational diabetes mellitus (GDM). Methods: We performed a case-control including 964 unrelated pregnant women GDM 1,021 normal glucose tolerance (as controls). A total 33 confirmed by GWA studies for were selected measured. Results: observed that FTO rs1121980 KCNQ1...
Background and Aims: Exosomes contain numerous RNAs transfer them between cells or organs, thereby establishing intercellular interorgan communication. The roles of mRNAs long noncoding (lncRNAs) from umbilical cord blood exosomes in gestational diabetes mellitus (GDM) occurrence fetus growth remain poorly understood. We aimed to establish the differential mRNA lncRNA expression profiles GDM patients compared with normal controls. Results: Using microarray technology, we identified 84 256...
Objective To investigate the association between time of day sports-related physical activity and onset acute myocardial infarction (AMI) in a coronary artery disease (CAD) population China. Methods Between February 2014 March 2015, total 696 patients from Nanjing, China, who had CAD were studied divided into two groups (Non-AMI AMI groups). The work-related information obtained self-reporting predesigned patient questionnaire. Results Sports-related was associated with lower risk AMI, after...
This study aimed to explore daptomycin combined with fosfomycin or rifampin against the planktonic and adherent linezolid-resistant isolates of Enterococcus faecalis.Four four linezolid-sensitive E. faecalis which formed biofilms were collected for this study. Biofilm biomasses detected by crystal violet staining cells in mature quantified c.f.u. determination.Daptomycin alone, (4×MIC) demonstrated bactericidal activities on cells, killed more (at least 1-log10 ml-1) than alone. Daptomycin...
Cervical cancer is a serious public health problem in developing countries. We investigated possible risk factors for cervical rural areas of Wuhan China using matched case-control study with 33 women diagnosed and 132 healthy selected from the same area as controls. A questionnaire, which included questions about general demography conditions, environmental genetic factors, first sexual intercourse, marriage age, age at pregnancy, pregnancy child's female personal history, social...
Intrahepatic cholestasis of pregnancy (ICP) is a severe liver disorder occurring specifically in pregnancy, and matrix metalloproteinase (MMP)-2 MMP-9 were found to be elevated ICP patients. Using ethinylestradiol-induced rats as the model, we examined effect resveratrol on symptoms such bile flow rate, serum enzymatic activities, TBA concentration, well MMP levels, compared with known drug ursodeoxycholic acid. Both MMP-2 upregulated rats, treatment could inhibit elevation both MMPs,...
This study described an index of aspartate aminotransferase-to-platelet ratio (APRI) to assess hepatic fibrosis with limited expense and widespread availability compared the liver biopsy in adolescent patients CHB.
Background/Aims: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific disease that significantly increases the risk fetal complications. Here, we measured serum miRNA levels in ICP patients to identify candidate biomarkers for ICP. Methods: We used Agilent array followed by reverse transcription-polymerase chain reaction assays and validate profiles 40 pregnant women with healthy controls. bioinformatics metabolic processes related differentially expressed miRNAs. Results: The...