A5015215431- Pregnancy and preeclampsia studies
- MicroRNA in disease regulation
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Reproductive System and Pregnancy
- Biomarkers in Disease Mechanisms
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Genetic Associations and Epidemiology
- Fibroblast Growth Factor Research
- Extracellular vesicles in disease
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer, Hypoxia, and Metabolism
- Biochemical effects in animals
- Anesthesia and Neurotoxicity Research
- Adipokines, Inflammation, and Metabolic Diseases
- Infant Nutrition and Health
- Metabolism, Diabetes, and Cancer
- Advanced Proteomics Techniques and Applications
- Connexins and lens biology
- Adipose Tissue and Metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Folate and B Vitamins Research
- Nicotinic Acetylcholine Receptors Study
Nanjing Maternity and Child Health Care Hospital
2016-2020
Nanjing Medical University
2016-2020
Oxidative stress is a major cause of adverse outcomes in preeclampsia (PE). Ferroptosis, i.e. programmed cell death from iron-dependent lipid peroxidation, likely mediates PE pathogenesis. We evaluated specific markers for ferroptosis normal and placental tissues, using vitro (trophoblasts) vivo (rat) models. Increase malondialdehyde content total Fe2+ along with reduced the glutathione peroxidase activity was observed placenta. While trophoblasts experienced under hypoxia, inhibitors...
Ovarian cancer (OC) is a common malignant tumor in the female reproductive system. Paclitaxel resistance primary cause of treatment failure patients with OC. Therefore, elucidating mechanisms by which OC develops paclitaxel crucial for achieving better therapeutic outcomes. This study analyzed data from GSE50831 (the response 21 cell lines to paclitaxel), GSE26193 progression 107 OC) datasets, and Cancer Genome Atlas (TCGA). Key differentially expressed genes were selected through...
Preeclampsia (PE) and its complications have become the leading cause of maternal fetal morbidity mortality in world. And development PE is still barely predictable thus challenging to prevent manage clinically. Oxidative stress contributes disease. Our previous study demonstrated that exogenous Alpha-1 antitrypsin (AAT) played a cytoprotective role vascular endothelial cell by suppressing oxidative stress. In this study, we aim investigate whether AAT PE, identify mechanism behind these...
This present study was designed to investigate the effects of alpha-1-antitrypsin (AAT) on oxidative stress in preeclampsia (PE) by regulating p38 mitogen-activated protein kinase (p38MAPK) signaling pathway. HTR8/SVneo cells were randomly assigned into normal, hypoxia/reoxygenation (H/R), HR + AAT and siRNA-AAT groups. Quantitative real-time polymerase chain reaction (qRT-PCR) Western blotting used detect mRNA expressions p-p38MAPK, AAT, signal transducer activator transcription 1 (STAT1)...
Abstract Circular RNA (circRNA) is a novel member of endogenous noncoding RNAs with widespread distribution and diverse cellular functions. Recently, circRNAs have been identified for their enrichment stability in exosomes. However, the roles from umbilical cord blood exosomes gestational diabetes mellitus (GDM) occurrence fetus growth remains poorly understood. In present study, we used microarray technology to construct comparative circRNA profiling between GDM patients controls. We found...
Introduction: New genetic variants associated with susceptibility to obesity and metabolic diseases have been discovered in recent genome-wide association (GWA) studies. The aim of this study was investigate the theses risk gestational diabetes mellitus (GDM). Methods: We performed a case-control including 964 unrelated pregnant women GDM 1,021 normal glucose tolerance (as controls). A total 33 confirmed by GWA studies for were selected measured. Results: observed that FTO rs1121980 KCNQ1...
Background and Aims: Exosomes contain numerous RNAs transfer them between cells or organs, thereby establishing intercellular interorgan communication. The roles of mRNAs long noncoding (lncRNAs) from umbilical cord blood exosomes in gestational diabetes mellitus (GDM) occurrence fetus growth remain poorly understood. We aimed to establish the differential mRNA lncRNA expression profiles GDM patients compared with normal controls. Results: Using microarray technology, we identified 84 256...
Pre-eclampsia (PE) is one of the most common reason for high morbidity and mortality maternal prenatal infants. Production from oxidative stress results in ROS system anti-oxidation defense imbalance to promote tissue ischemia hypoxia, ultimately impairs organs placenta. Our previous study showed that exogenous Alpha-1-antitrypsin (AAT) overexpression AAT umbilical vein cell (HUVEC) hypoxia-reoxygenation model could increase activity antioxidant enzymes, played a protective role preeclampsia...
// Ying Gu 1 , Yaling Feng Jinjin Yu 2 Hua Yuan Yongxiang Yin 3 Jian Ding Jun Zhao Yaohui Xu Jianjuan and Haisha Che Department of Obstetrics Gynecology, Wuxi Maternal Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214002, PR China The Jiangnan University (Wuxi Fourth People's Hospital), 214062, Pathology, Maternity Correspondence to: Feng, email: 15161506909@163.com Yu, fengyl523@sina.com Keywords: preeclampsia; fasudil; endothelial dysfunction; hypertension;...
Abstract Objective To explore the differential protein profile of preeclampsia and identify its potential biomarker. Methods Around 20 pregnant women with (preeclampsia group) normal‐term pregnancy (normal were collected from 2017 to 2018 in study. Total placenta tissues was extracted, denaturized, deoxidized, enzymolyzed. The sample labeled isobaric tags for relative absolute quantitation (iTRAQ) analyzed mass spectrum differentially expressed proteins. Results There 37 proteins, which...
Objective To explore the effects and significance of individualized nutrition guidance patients with polycystic ovary syndrome (PCOS) during pregnancy. Methods Between January 2010 March 2013, sixty eight pregnant women who were diagnosed as PCOS in Wuxi Maternal Child Health Hospital Affiliated to Nanjing Medical University recruited into study. They divided intervention group (n =36) control =32) . Intervention accepted nutritional guidance, follow traditional guidance. The...
Objective To investigate the expression and significance of vascular endothelial growth factor (VEGF) its receptor fms-like tyrosine kinase-1(Flt-1) in placenta for patients with intrahepatic cholestasis pregnancy (ICP). Methods From June 2009 to May 2010, 30 ICP (ICP group) normal third trimester pregnant women (control were included study. There had no significant differences age, gestational gravidity, parity modes delivery between two groups(P>0.05). The expressions VEGF Flt-1...
BACKGROUND:The aim of this study was to identify the differentially expressed proteins obese patients compared with normal participants and provide a potential target for future investigation obesity. MATERIAL AND METHODS:We enrolled 10 male adults matched subjects. Serum samples were collected get total protein extraction, denaturation, deoxidation, enzymatic hydrolysis. Differentially distinguished mass spectrometry after labeled iTRAQ. RESULTS:A 9622 peptides identified, corresponding 733...