A5101614401- Nonmelanoma Skin Cancer Studies
- Cutaneous lymphoproliferative disorders research
- Cutaneous Melanoma Detection and Management
- Pharmacogenetics and Drug Metabolism
- Microbial Metabolic Engineering and Bioproduction
- Enzyme Catalysis and Immobilization
- Body Contouring and Surgery
- Cancer-related molecular mechanisms research
- Inflammatory Myopathies and Dermatomyositis
- Dermatological and Skeletal Disorders
- Digital Imaging in Medicine
- Inflammatory Bowel Disease
- Cervical Cancer and HPV Research
- Video Surveillance and Tracking Methods
- Body Image and Dysmorphia Studies
- Software-Defined Networks and 5G
- AI in cancer detection
- Anatomy and Medical Technology
- Chronic Lymphocytic Leukemia Research
- Dental Anxiety and Anesthesia Techniques
- Sarcoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Nail Diseases and Treatments
- Endometrial and Cervical Cancer Treatments
- Fire Detection and Safety Systems
University of Wisconsin Carbone Cancer Center
2021-2025
University of Wisconsin–Madison
2018-2024
Merck Institute for Science Education
2024
State Key Laboratory of Biotherapy
2022
Sichuan University
2022
West China Hospital of Sichuan University
2022
Nanjing Maternity and Child Health Care Hospital
2017-2021
Nanjing Medical University
2017-2021
Ningbo University
2021
Baotou Medical College
2021
Basal cell carcinoma (BCC) is the most common form of skin cancer in United States. Due to high frequency, BCC occurrences are not typically recorded, and annual rates incidence can only be estimated. Current estimated 2 million Americans affected annually, this continues rise. Exposure radiation, from either sunlight or previous medical therapy, a key player development. as aggressive other cancers because it less likely metastasize. However, surgery radiation prevalent treatment options,...
The NCCN Guidelines for Merkel Cell Carcinoma (MCC) provide recommendations diagnostic workup, clinical stage, and treatment options patients. panel meets annually to discuss updates the guidelines based on comments from expert review members, institutional review, as well submissions within external organizations. These Insights focus introduction of a new page locally advanced disease in setting node negative status, entitled “Clinical N0 Disease, Locally Advanced MCC.” This algorithm...
Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous soft tissue sarcoma and affects an estimated 1,500 people annually in the United States. DFSP frequently exhibits extensive local infiltration. Initial treatment through surgical excision, care should be taken to ensure that negative margins are achieved minimize recurrence. Although has reported high rate of recurrence, metastasis more uncommon. Fibrosarcomatous aggressive variant with increased risk for recurrence metastasis. If...
The NCCN Guidelines for Squamous Cell Skin Cancer provide recommendations diagnostic workup, clinical stage, and treatment options patients with cutaneous squamous cell carcinoma. panel meets annually to discuss updates the guidelines based on comments from members Institutional Review, as well submissions within external organizations. These Insights focus introduction of a new surgical recommendation terminology (peripheral deep en face margin assessment), recent topical prophylaxis,...
Abstract The investigation of substrate spectrum towards five racemic ( rac -) aryl glycidyl ethers 1a – 5a ) indicated that E. coli / pveh3 , an BL21(DE3) transformant harboring a Pv EH3-encoding gene showed the highest EH activity and enantiomeric ratio E - 3a . For efficiently catalyzing kinetic resolution value EH3 were further improved by site-directed mutagenesis selected residues. Based on semi-rational design NC-loop in EH3, four single-site variants amplified PCR, intracellularly...
In this study, we described a series of 2,8-diazaspiro[4.5]decan-1-one derivatives as selective TYK2/JAK1 inhibitors. Systematic exploration the structure–activity relationship through introduction spirocyclic scaffolds based on reported TYK2 inhibitor 14l led to discovery superior derivative compound 48. Compound 48 showed excellent potency kinases with IC50 values 6 and 37 nM, respectively, exhibited more than 23-fold selectivity for JAK2. also demonstrated metabolic stability potent...
Peripheral and deep en face margin assessment (PDEMA), formerly termed by NCCN as complete circumferential peripheral (CCPDMA), has the advantages of histologic visualization entire marginal surface, highly accurate resection involved tissue, sparing uninvolved tissue. Owing to its highest reported cure rates, PDEMA is NCCN-preferred treatment for dermatofibrosarcoma protuberans, high-risk basal cell carcinoma, very-high-risk cutaneous squamous carcinoma. In United States, Mohs micrographic...
// Ying Gu 1 , Yaling Feng Jinjin Yu 2 Hua Yuan Yongxiang Yin 3 Jian Ding Jun Zhao Yaohui Xu Jianjuan and Haisha Che Department of Obstetrics Gynecology, Wuxi Maternal Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214002, PR China The Jiangnan University (Wuxi Fourth People's Hospital), 214062, Pathology, Maternity Correspondence to: Feng, email: 15161506909@163.com Yu, fengyl523@sina.com Keywords: preeclampsia; fasudil; endothelial dysfunction; hypertension;...
Abstract Background Epoxide hydrolase can regioselectively catalyze the oxirane ring-opening hydrolysis of rac -epoxides producing corresponding chiral diols. In our laboratory, a gene named pveh1 encoding an EH from Phaseolus vulgaris was cloned. Although directed modification Pv EH1 carried out, mutant Y3 showed limited degree enantioconvergence towards racemic ( -) m -chlorostyrene oxide CSO). Results and were combinatively subjected to laboratory evolution further enhance - CSO. Firstly,...
Background: Previous studies have proven that Purinostat Mesylate (PM) is a new HDAC inhibitor and exhibits significant antitumor efficacy. However, the clinical application of PM was greatly limited by its poor solubility in water low bioavailability.Objective:To increase through pharmaceutical research, prepare it into an injection meets needs intravenous use to promote application.MethodsThe prepared PM/HP-β-CD inclusion complex studied computer simulation, fourier transform infrared...
In recent years, with the development of network technology and real estate industry, intelligent apartments are becoming more popular. The door lock equipment is Compared traditional lock, has higher security convenience. user controls through mobile device, apartment computer. or electronic access card, it convenient. Therefore, a management system that can manage locks intelligently Internet great significance to industry social development. this paper, using existing knowledge in...
To the Editor: There is a higher incidence of nonmelanoma skin cancer in patients with chronic lymphocytic leukemia and it seems to exhibit heightened aggressive nature rates recurrence after Mohs surgery.1Mehrany K. Weenig R.H. Pittelkow M.R. Roenigk R.K. Otley C.C. High basal cell carcinoma surgery leukemia.Arch Dermatol. 2004; 140: 985-988Crossref PubMed Scopus (61) Google Scholar,2Mehrany squamous Mohs' leukemia.Dermatol Surg. 2005; 31: 38-42Crossref (79) Scholar are many postulated...
A 7–month‐old healthy white boy presented for evaluation of a papule on his right ear. His mother reported small cut‐like lesion at this site shortly after birth that had gradually grown over time. The patient was born full term via repeat cesarean section. On physical examination, located the superior helix, there 5–6 mm, pink, firm with rough scaly surface and peripheral erythema ( Figure 1 ). shave excised sent histologic analysis. Microscopic examination revealed defect epidermis...
Kidney transplant recipients (KTRs) have an increased risk of skin cancer. We analyzed the outcomes KTRs transplanted at our center between January 1, 1994, and December 31, 2015, who reported pretransplant melanoma or had post-transplant de novo melanoma. Of 6,522 kidney with pancreas recipients, 37 After adjustment multiple variables, was associated overall death (HR: 1.75, 95% CI 1.02 - 3.03, p = 0.04) but not for death-censored graft failure (DCGF). A total 46 patients developed...