A5018908130- Nonmelanoma Skin Cancer Studies
- Cancer Genomics and Diagnostics
- Dermatologic Treatments and Research
- Cutaneous Melanoma Detection and Management
- Cancer and Skin Lesions
- Retinoids in leukemia and cellular processes
- Reconstructive Facial Surgery Techniques
- Psoriasis: Treatment and Pathogenesis
- Nail Diseases and Treatments
- BRCA gene mutations in cancer
- Reconstructive Surgery and Microvascular Techniques
- Breast Cancer Treatment Studies
- Sympathectomy and Hyperhidrosis Treatments
- Surgical Sutures and Adhesives
- Autoimmune Bullous Skin Diseases
- Sarcoma Diagnosis and Treatment
- Facial Rejuvenation and Surgery Techniques
- Surgical site infection prevention
- Body Contouring and Surgery
- Ear and Head Tumors
- Polyomavirus and related diseases
- Dental Anxiety and Anesthesia Techniques
- Genetic and rare skin diseases.
- Vascular Tumors and Angiosarcomas
- AI in cancer detection
University of California, San Francisco
2014-2024
UCSF Helen Diller Family Comprehensive Cancer Center
2021-2024
VA Northern California Health Care System
2018
Memorial Sloan Kettering Cancer Center
2014
University of Alabama at Birmingham
2014
Brigham and Women's Hospital
2011
University of California, Berkeley
2011
Samsung (South Korea)
2011
Broad Institute
2011
Oregon Health & Science University
2011
This selection from the NCCN Guidelines for Merkel Cell Carcinoma (MCC) focuses on areas impacted by recently emerging data, including sections describing MCC risk factors, diagnosis, workup, follow-up, and management of advanced disease with radiation systemic therapy. Included in these are discussion new recommendations use cell polyomavirus as a biomarker checkpoint immunotherapies to treat metastatic or unresectable disease. The next update complete version will include more detailed...
Timely intervention for cancer requires knowledge of its earliest genetic aberrations. Sequencing tumors and their metastases reveals numerous abnormalities occurring late in progression. A means to temporally order aberrations a single cancer, rather than inferring them from serially acquired samples, would define changes preceding even clinically evident disease. We integrate DNA sequence copy number information reconstruct the as individual evolve 2 separate types. detect vast, unreported...
Basal cell carcinoma (BCC) of the skin is most common cancer, with a higher incidence than all other malignancies combined. Although it rare to metastasize, patients multiple or frequently recurring BCC can suffer substantial comorbidity and be difficult manage. Assessment risk key element management needed inform treatment selection. The overall primarily consists surgical approaches, radiation therapy as an alternate adjuvant option. Many superficial therapies for have been explored...
The NCCN Guidelines for Squamous Cell Skin Cancer provide recommendations diagnostic workup, clinical stage, and treatment options patients with cutaneous squamous cell carcinoma. panel meets annually to discuss updates the guidelines based on comments from members Institutional Review, as well submissions within external organizations. These Insights focus introduction of a new surgical recommendation terminology (peripheral deep en face margin assessment), recent topical prophylaxis,...
Inflammatory conditions represent the largest class of chronic skin disease, but molecular dysregulation underlying many individual cases remains unclear. Single-cell RNA sequencing (scRNA-seq) has increased precision in dissecting complex mixture immune and stromal cell perturbations inflammatory disease states. We single-cell–profiled CD45 + transcriptomes from samples 31 patients (7 atopic dermatitis, 8 psoriasis vulgaris, 2 lichen planus (LP), 1 bullous pemphigoid (BP), 6...
<h3>Background</h3> Microcystic adnexal carcinoma, or sclerosing sweat duct is an uncommon cutaneous neoplasm associated with extensive local invasion. The standard of care regard to the best excisional method in treating microcystic carcinoma has not been established. <h3>Objectives</h3> To perform a retrospective study comparing patients treated by Mohs micrographic surgery those wide excision and elucidate epidemiological features carcinoma. <h3>Patients Methods</h3> A analysis case...
The main objective of the present study is to demonstrate feasibility utilizing a novel non-invasive radiofrequency (RF) device induce lethal thermal damage subcutaneous adipose tissue only by establishing controlled electric field that heats up fat preferentially.Adipocyte cells in six-well plates were subjected hyperthermic conditions: 45, 50, 55, 60, and 65 degrees C during 1, 2, 3 minutes. Cell viability was assessed 72 hours after exposure. Two groups abdominoplasty patients treated...
<h3>Importance</h3> Melanoma in situ (MIS) is increasing incidence, and expert consensus opinion recommends surgical excision for therapeutic management. Currently, wide local (WLE) the standard of care. However, Mohs micrographic surgery (MMS) now used to treat a growing subset individuals with MIS. During MMS, unlike WLE, entire cutaneous margin evaluated intraoperatively tumor cells. <h3>Objective</h3> To assess outcomes patients MIS treated MMS compared those WLE. <h3>Design, Setting,...
Psoriasis vulgaris and other chronic inflammatory diseases improve markedly with therapeutic blockade of interleukin-23 (IL-23) signaling, but the genetic mechanisms underlying clinical responses remain poorly understood. Using single-cell transcriptomics, we profiled immune cells isolated from lesional psoriatic skin before during IL-23 blockade. In clinically responsive patients, a transcriptional signature in skin-resident memory T was strongly attenuated. contrast, patients were...
background . Benign pigmented lesions are of a cosmetic concern to many individuals. Numerous treatments exist, including several types lasers. The Candela 510 nm lesion dye laser has recently been added this armamentarium. It is designed specifically for the treatment superficial while significantly decreasing risk scarring and prolonged hypopigmentation.n objectives To describe characteristics report on therapeutic outcome patients treated actinic lentigines, café‐aulait macules, melasma...
There is evidence suggesting a role of eicosanoids in the growth certain tumors. In this study, tissue samples were collected from basal cell carcinomas (BCCs) and squamous (SCCs) skin. Both BCCs SCCs contained more prostaglandin E2 F2 alpha (PGE2 PGF2 alpha) than normal epidermis. vitro incubation tumor with arachidonic acid also resulted PGE2 formation. Basal exhibiting histologically aggressive pattern higher levels prostaglandins those nonaggressive pattern, both vivo after incubation....
][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Several large reviews document the development of local recurrence in 25% to 30% all cases MCC, regional disease 52% 59%, and distant metastatic 34% 36%. 1,16,17CC has a mortality rate that exceeds melanoma; 18 overall 5-year survival rates range from 64%. 3,19A history extensive sun exposure is
PReferentially expressed Antigen in MElanoma (PRAME) immunohistochemical (IHC) staining is used to aid melanoma diagnosis. PRAME expression nevus-associated (NAM) has not been evaluated.PRAME IHC was applied cases of NAM; for each population melanocytes (benign and malignant) graded based on the percentage labeled cells. No labeling 0, 1% 25% 1+, 26% 50% 2+, 51% 75% 3+, >76% 4+.Thirty-six were reviewed. Sixty-seven percent (24/36) melanomas positive (4+) while no (0/36) nevi showed 4+...
Penile tumors represent a difficult group of neoplasms requiring effective and curative treatment while minimizing tissue loss to prevent cosmetic functional deformity. Over the past 6 years, we have treated 20 patients with penile cancer utilizing fresh technique Mohs micrographic surgery. Tumors were excised an average 2.25 stages. Most defects (80%) allowed heal by second intention. Since surgery, four developed metastatic disease in their regional lymphatic system, one patient has died...
Merkel cell carcinoma is a rare, aggressive cutaneous tumor that combines the local recurrence rates of infiltrative nonmelanoma skin cancer with regional and distant metastatic thick melanoma. The NCCN Guidelines for Cell Carcinoma provide recommendations on diagnosis management this disease based clinical evidence expert consensus. This version includes revisions regarding use PET/CT imaging addition new section principles pathology to guidance analysis, interpretation, reporting results.
Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft tissue tumor characterized by a relatively high risk of local recurrence and low metastasis. The NCCN Guidelines for DFSP provide multidisciplinary recommendations on the management patients with this rare disease. These Insights highlight addition Principles Pathology section, which provides pathologic assessment DFSP. Because can mimic other lesions, immunohistochemical studies are often required to establish diagnosis. Cytogenetic...