A5103277799- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
- Traumatic Brain Injury Research
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Fire effects on ecosystems
- Dementia and Cognitive Impairment Research
- Cerebral Venous Sinus Thrombosis
- Single-cell and spatial transcriptomics
- Blood Pressure and Hypertension Studies
- IL-33, ST2, and ILC Pathways
- Data-Driven Disease Surveillance
- Viral Infections and Outbreaks Research
- Psoriasis: Treatment and Pathogenesis
- Critical Race Theory in Education
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Data Quality and Management
- Viral Infections and Vectors
- CAR-T cell therapy research
- Survey Methodology and Nonresponse
University of California, San Francisco
2023-2024
San Francisco VA Health Care System
2024
San Francisco VA Medical Center
2023
University of British Columbia
2020
RTI International
2014-2017
Emerging data suggest that direct oral anticoagulants may be a suitable choice for anticoagulation cerebral venous thrombosis (CVT). However, conducting high-quality trials in CVT is challenging as it rare disease with low rates of adverse outcomes such major bleeding and functional dependence. To facilitate the design future trials, SECRET (Study Rivaroxaban Cerebral Venous Thrombosis) assessed (1) feasibility recruitment, (2) safety rivaroxaban compared standard-of-care anticoagulation,...
Psoriasis vulgaris and other chronic inflammatory diseases improve markedly with therapeutic blockade of interleukin-23 (IL-23) signaling, but the genetic mechanisms underlying clinical responses remain poorly understood. Using single-cell transcriptomics, we profiled immune cells isolated from lesional psoriatic skin before during IL-23 blockade. In clinically responsive patients, a transcriptional signature in skin-resident memory T was strongly attenuated. contrast, patients were...
Background Severe fever with thrombocytopenia syndrome virus ( SFTSV ), an emerging tick‐borne pathogen that can cause fatal severe syndrome, was first identified in C hina 2009. Limited evidence suggests be transmitted between humans via blood contact, raising concerns over transfusion safety. A study of donor samples from three hinese centers conducted to investigate the seroprevalence and rate viremia among donors. Study Design Methods From pril 16 O ctober 31, 2012, a total 17,208 plasma...
Single-cell RNA sequencing (scRNA-seq) allows for high-resolution analysis of transcriptionally dysregulated cell subpopulations in inflammatory diseases. However, it can be challenging to properly isolate viable immune cells from human skin scRNA-seq due its barrier properties. Here, we present a protocol high-viability cutaneous cells. We describe steps obtaining and enzymatically dissociating biopsy specimen isolating using flow cytometry. then provide an overview downstream computational...
The U.S. Census Bureau in 2016 developed a testing version of the Internet data collection instrument for 2020 Chinese language to assess its usability among those residents who can read and write but have limited English proficiency. purpose this study was characterize cultural- linguistic-specific issues propose recommendations resolving issues. Thirteen native speakers participated study. Each participant completed Test Instrument alone using laptop or mobile device (a tablet smartphone)....
Abstract Objective: To evaluate an abbreviated NIH Toolbox Cognition Battery (NIHTB-CB) protocol that can be administered remotely without any in-person assessments, and explore the agreement between prorated scores from standard full protocol. Methods: Participant-level age-corrected NIHTB-CB data were extracted six studies in individuals with a history of stroke, mild traumatic brain injury (mTBI), treatment-resistant psychosis, healthy controls, testing under conditions. Prorated fluid...
Many patients do not respond to targeted pathway-specific biologic therapies but predicting such failure remains an outstanding challenge. Here, in a case of adult-onset hand dermatitis that did multiple therapies, we detected gene expression programs activated both atopic and psoriasis, via high-resolution genetic profiling. Broader, kinase-based immunosuppression elicited near complete clinical response. Therefore, our data suggest cases harboring greater molecularly complexity might be...