A5014370578- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Cancer and Skin Lesions
- Cutaneous lymphoproliferative disorders research
- Optical Coherence Tomography Applications
- Skin Protection and Aging
- Clinical practice guidelines implementation
- Nail Diseases and Treatments
- Reconstructive Facial Surgery Techniques
- Infectious Diseases and Mycology
- Dermatologic Treatments and Research
- Cell Image Analysis Techniques
- Hedgehog Signaling Pathway Studies
- Sarcoma Diagnosis and Treatment
- Global Healthcare and Medical Tourism
- Ear and Head Tumors
- Tumors and Oncological Cases
- AI in cancer detection
- Cancer Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Digital Imaging in Medicine
- Ocular Oncology and Treatments
- Wound Healing and Treatments
- Polyomavirus and related diseases
- Genetic and rare skin diseases.
Memorial Sloan Kettering Cancer Center
2016-2025
Cornell University
2000-2024
Northwestern University
2020-2024
Merck Institute for Science Education
2024
University of Southern California
2020-2023
Columbia University Irving Medical Center
1998-2017
Weill Cornell Medicine
2017
New York Hospital Queens
2017
NewYork–Presbyterian Hospital
2017
NYU Langone Health
2017
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen that was isolated by autologous T cells melanoma patient. While frequent mRNA expression well documented cutaneous and ocular melanomas, little known about protein melanocytic tumors. In this study we examined the immunohistochemical of 400 tumors, including 155 primary 100 metastatic 145 nevi. Diffuse nuclear immunoreactivity for found 87% 83.2% melanomas. Among subtypes, diffusely 94.4% acral 92.5%...
This selection from the NCCN Guidelines for Merkel Cell Carcinoma (MCC) focuses on areas impacted by recently emerging data, including sections describing MCC risk factors, diagnosis, workup, follow-up, and management of advanced disease with radiation systemic therapy. Included in these are discussion new recommendations use cell polyomavirus as a biomarker checkpoint immunotherapies to treat metastatic or unresectable disease. The next update complete version will include more detailed...
Basal cell carcinoma (BCC) of the skin is most common cancer, with a higher incidence than all other malignancies combined. Although it rare to metastasize, patients multiple or frequently recurring BCC can suffer substantial comorbidity and be difficult manage. Assessment risk key element management needed inform treatment selection. The overall primarily consists surgical approaches, radiation therapy as an alternate adjuvant option. Many superficial therapies for have been explored...
Basal cell carcinoma (BCC) is the most common form of skin cancer in United States. Due to high frequency, BCC occurrences are not typically recorded, and annual rates incidence can only be estimated. Current estimated 2 million Americans affected annually, this continues rise. Exposure radiation, from either sunlight or previous medical therapy, a key player development. as aggressive other cancers because it less likely metastasize. However, surgery radiation prevalent treatment options,...
The NCCN Guidelines for Merkel Cell Carcinoma (MCC) provide recommendations diagnostic workup, clinical stage, and treatment options patients. panel meets annually to discuss updates the guidelines based on comments from expert review members, institutional review, as well submissions within external organizations. These Insights focus introduction of a new page locally advanced disease in setting node negative status, entitled “Clinical N0 Disease, Locally Advanced MCC.” This algorithm...
Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous soft tissue sarcoma and affects an estimated 1,500 people annually in the United States. DFSP frequently exhibits extensive local infiltration. Initial treatment through surgical excision, care should be taken to ensure that negative margins are achieved minimize recurrence. Although has reported high rate of recurrence, metastasis more uncommon. Fibrosarcomatous aggressive variant with increased risk for recurrence metastasis. If...
Mosaicing of confocal images enables observation nuclear morphology in large areas tissue. An application interest is rapid detection basal cell carcinomas (BCCs) skin excisions during Mohs surgery. A mosaic currently created less than 9 min, whereas preparing frozen histology requires 20 to 45 min for an excision. In reflectance mosaics, using acetic acid as a contrast agent brighten nuclei, and densely nucleated BCC tumors were detectable fields view 12 x mm (which equivalent 2x-magnified...
The NCCN Guidelines for Squamous Cell Skin Cancer provide recommendations diagnostic workup, clinical stage, and treatment options patients with cutaneous squamous cell carcinoma. panel meets annually to discuss updates the guidelines based on comments from members Institutional Review, as well submissions within external organizations. These Insights focus introduction of a new surgical recommendation terminology (peripheral deep en face margin assessment), recent topical prophylaxis,...
<h3>Objective:</h3> To define the spectrum of disease in cases hypopigmentation and hyperpigmentation along lines Blaschko more accurately. Pigmentary anomalies Blaschko, including hypomelanosis Ito, linear whorled nevoid hypermelanosis, nevus depigmentosus, can be associated with notable abnormal systemic features. We believe that incidence features described previous studies is exaggerated owing to referral reporting bias. <h3>Design:</h3> Retrospective review case series....
Precise removal of basal cell carcinomas (BCCs) with minimal damage to the surrounding normal skin is guided by examination frozen histology each excision during Mohs surgery. The preparation slow, requiring 20 45 min per excision. Confocal reflectance mosaicing may enable rapid detection BCCs directly in surgical excisions, need for histology. Soaking excisions acetic acid rapidly brightens nuclei and enhances BCC-to-dermis contrast. Clinically useful concentrations from 10 1% require 30 s...
][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Several large reviews document the development of local recurrence in 25% to 30% all cases MCC, regional disease 52% 59%, and distant metastatic 34% 36%. 1,16,17CC has a mortality rate that exceeds melanoma; 18 overall 5-year survival rates range from 64%. 3,19A history extensive sun exposure is