A5043322306- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Prostate Cancer Treatment and Research
- Urological Disorders and Treatments
- Medical Imaging Techniques and Applications
- Nonmelanoma Skin Cancer Studies
- Esophageal Cancer Research and Treatment
- Radiopharmaceutical Chemistry and Applications
- Sarcoma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Radiation Dose and Imaging
- Renal cell carcinoma treatment
- Effects of Radiation Exposure
- Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Polyomavirus and related diseases
- Nanoplatforms for cancer theranostics
- Full-Duplex Wireless Communications
- Antenna Design and Analysis
University of Pennsylvania
2016-2025
Springfield Clinic
2023-2025
Washington University in St. Louis
2017-2024
Lawrence Livermore National Laboratory
2008-2024
Jewish Hospital
2021-2023
Barnes-Jewish Hospital
2021-2023
Emory University
2023
Quantitative BioSciences
2022
Hospital of the University of Pennsylvania
2012-2019
GTx (United States)
2019
Successful treatment of brain tumors such as glioblastoma multiforme (GBM) is limited in large part by the cumulative dose Radiation Therapy (RT) that can be safely given and blood-brain barrier (BBB), which limits delivery systemic anticancer agents into tumor tissue. Consequently, overall prognosis remains grim. Herein, we report our pilot studies cell culture experiments an animal model GBM RT complemented PEGylated-gold nanoparticles (GNPs). GNPs significantly increased cellular DNA...
Concurrent chemoradiotherapy is the standard-of-care curative treatment for many cancers but associated with substantial morbidity. administered proton therapy might reduce toxicity and achieve comparable cancer control outcomes compared conventional photon radiotherapy by reducing radiation dose to normal tissues.To assess whether in setting of concurrent fewer 90-day unplanned hospitalizations (Common Terminology Criteria Adverse Events, version 4 [CTCAEv4], grade ≥3) or other adverse...
Abstract Circulating tumor DNA (ctDNA) sensitivity remains subpar for molecular residual disease (MRD) detection in bladder cancer patients. To remedy this problem, we focused on the biofluid most proximal to disease, urine, and analyzed urine 74 localized We integrated ultra-low-pass whole genome sequencing (ULP-WGS) with personalized profiling by deep (uCAPP-Seq) achieve sensitive MRD predict overall survival. Variant allele frequency, inferred mutational burden, copy number-derived...
The treatment of glioblastoma multiforme, the most prevalent and lethal form brain cancer in humans, has been limited part by poor delivery drugs through blood-brain barrier unclear delineation extent infiltrating tumor margins. Nanoparticles, which selectively accumulate tissue due to their leaky vasculature enhanced permeability retention effect, have shown promise as both therapeutic diagnostic agents for tumors. In particular, superparamagnetic iron oxide nanoparticles (SPIONs) leveraged...
The NCCN Guidelines for Squamous Cell Skin Cancer provide recommendations diagnostic workup, clinical stage, and treatment options patients with cutaneous squamous cell carcinoma. panel meets annually to discuss updates the guidelines based on comments from members Institutional Review, as well submissions within external organizations. These Insights focus introduction of a new surgical recommendation terminology (peripheral deep en face margin assessment), recent topical prophylaxis,...
Background The standard of care treatment for muscle-invasive bladder cancer (MIBC) is radical cystectomy, which typically preceded by neoadjuvant chemotherapy. However, the inability to assess minimal residual disease (MRD) noninvasively limits our ability offer bladder-sparing treatment. Here, we sought develop a liquid biopsy solution via urine tumor DNA (utDNA) analysis. Methods and findings We applied Cancer Personalized Profiling Deep Sequencing (uCAPP-Seq), targeted next-generation...
Locoregional failure for patients with locally advanced bladder cancer (LABC) after radical cystectomy (RC) is common even chemotherapy and associated high morbidity mortality. Adjuvant radiotherapy (RT) can decrease locoregional but has not been studied in the era.To investigate if adjuvant sequential RT plus improve recurrence-free survival (LRFS) compared alone.A randomized phase 3 trial was opened to compare vs RC LABC, a third arm added later as 2 alone, an emerging standard. The...
Background/Objectives Oligometastatic sarcoma pulmonary metastases (PM) are typically treated with resection and/or chemotherapy. We hypothesize that stereotactic body radiotherapy (SBRT) can be an alternative to surgery achieve high rates of local control (LC) limited toxicity. Methods Thirty consecutive patients received SBRT 39 PM's from 2011 2015 at two university hospitals a median dose 50 Gy in 4–5 fractions CyberKnife or linear accelerator. Patients underwent CT PET/CT scans q3 months...
BACKGROUND Clinical trials of radiation after radical cystectomy (RC) and chemotherapy for bladder cancer are in development, but inclusion stratification factors have not been clearly established. In this study, the authors evaluated refined a published risk locoregional failure (LF) by applying it to multicenter patient cohort. METHODS The original stratification, which was developed using single‐institution series, produced 3 subgroups with significantly different LF based on pathologic...
BACKGROUND Risk stratification is a major challenge in bladder cancer (BC), and biomarker needed. Multiple studies have reported the neutrophil‐to‐lymphocyte ratio (NLR) as promising candidate; however, these analyses methodological limitations. Therefore, authors performed category B study to test whether NLR prognostic for overall survival (OS) after curative treatment or predictive benefit from neoadjuvant chemotherapy (NAC). METHODS This an unplanned secondary analysis of SWOG 8710,...
Glioblastoma multiforme (GBM) is a common, usually lethal disease with median survival of only ~15 months. It has proven resistant in clinical trials to chemotherapeutic agents such as paclitaxel that are highly effective vitro, presumably because impaired drug delivery across the tumor's blood-brain barrier (BBB). In an effort increase tumor BBB, we linked novel filomicelle nanocarrier made biodegradable poly(ethylene-glycol)-block-poly(ε-caprolactone-r-D,L-lactide) and used precisely...
No AccessJournal of UrologyAdult Urology1 Feb 2018Treatment Patterns and Overall Survival Outcomes Octogenarians with Muscle Invasive Cancer the Bladder: An Analysis National Database Benjamin W. Fischer-Valuck, Yuan James Rao, Soumon Rudra, Daniel Przybysz, Elizabeth Germino, Pamela Samson, Brian C. Baumann, Hiram Gay, Jeff Michalski Fischer-ValuckBenjamin Fischer-Valuck More articles by this author , RaoYuan Rao RudraSoumon Rudra PrzybyszDaniel Przybysz GerminoElizabeth Germino...
Background: Retroperitoneal sarcomas (RPS) are rare and primarily managed with surgery, which improves local recurrence-free overall survival. Radiation can improve control or provide palliation for inoperable metastatic RPS by eliciting tumor cell death via irreparable DNA damage. In extraordinary circumstances radiation-induced promotes immune-mediated regression of non-irradiated lesions in a process termed the abscopal effect. Abscopal effects incompletely understood, involving balance...
<h3>Importance</h3> Current recommendations regarding the size of local excision (LE) margins for Merkel cell carcinoma (MCC) have not been well established. <h3>Objective</h3> To assess whether larger clinical LE and receipt adjuvant radiotherapy are associated with improvements in overall survival (OS) among patients localized MCC. <h3>Design, Setting, Participants</h3> This large multicenter retrospective cohort study used records from National Cancer Database to identify adult stage I or...
The comparative cardiovascular risk profiles of available hormone therapies for the treatment prostate cancer is not known.We queried U.S. Food and Drug Administration Adverse Event Reporting System, a retrospective, pharmacovigilance database, adverse event reports in men with receiving gonadotropin releasing (GnRH) agonists, GnRH antagonists, androgen receptor and/or synthesis inhibitors from January 2000 to April 2020.Cardiovascular events accounted 6,231 (12.6%) on monotherapy 1,793...
Therapeutic drug monitoring (TDM) of the atypical antipsychotic clozapine is recommended. Clinical studies have indicated a therapeutic window for serum levels in schizophrenic and schizo-affective patients during acute treatment, i.e. who do not respond to treatment with typical antipsychotics. However, despite frequent use also maintenance very few data are available showing relationship between prevention relapse. Thus, primary objective study was investigate ofclozapine relapse...