A5034249346- Breast Cancer Treatment Studies
- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- HER2/EGFR in Cancer Research
- Head and Neck Cancer Studies
- Immunotherapy and Immune Responses
- Advanced Breast Cancer Therapies
- Prostate Cancer Treatment and Research
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- Cancer Risks and Factors
- Peptidase Inhibition and Analysis
- Lymphoma Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- CAR-T cell therapy research
- Estrogen and related hormone effects
- Advances in Oncology and Radiotherapy
- Cancer Immunotherapy and Biomarkers
- Salivary Gland Tumors Diagnosis and Treatment
- Immune Response and Inflammation
- Urinary and Genital Oncology Studies
- Male Breast Health Studies
- Radiation Therapy and Dosimetry
- Cancer Diagnosis and Treatment
- Medical Image Segmentation Techniques
University of Saskatchewan
2004-2023
Saskatchewan Cancer Agency
2006-2023
Loyola University Chicago
2010
The Netherlands Cancer Institute
1993
It remains unknown whether or not short-term androgen deprivation (STAD) improves survival among men with intermediate-risk prostate cancer (IRPC) treated dose-escalated radiotherapy (RT).
Fiducial markers and daily electronic portal imaging (EPI) can reduce the risk of geographic miss in prostate cancer radiotherapy. The purpose this study was to estimate CTV PTV margin requirements, without with use image guidance strategy. 46 patients underwent placement 3 radio-opaque fiducial prior RT. Daily pre-treatment EPIs were taken, isocenter errors corrected if they ≥ mm along left-right or superior-inferior axes, and/or 2 anterior-posterior axis. During-treatment then obtained...
PURPOSE Long-term androgen deprivation therapy (ADT) improves survival in men with high-risk localized prostate cancer (PCa) receiving radiotherapy (RT). Predictive biomarkers are needed to guide ADT duration. METHODS A multimodal artificial intelligence (MMAI)–derived predictive biomarker was trained for long-term (LT) versus short-term (ST) using pretreatment digital biopsy images and clinical data (age, prostate-specific antigen, Gleason, T stage) from six NRG Oncology phase III...
Adjuvant trastuzumab has been associated with superior survival in women ≥ T1c or node-positive HER2-positive early-stage breast cancer; however, there is a lack of phase III trials T1a/bN0 disease. Our study aimed to assess the outcomes cancer who received adjuvant Saskatchewan, Canada. We evaluated all diagnosed Saskatchewan between 2008 and 2017. performed Cox proportional multivariable analysis determine factors correlated survival. In addition, inverse probability treatment weighting...
Abstract Background Tumor metastasis and relapse are major obstacles in combating human malignant diseases. Neither radiotherapy alone nor injection of dendritic cells (DCs) can successfully overcome this problem. Radiation induces tumor cell apoptosis necrosis, resulting the release antigen danger signals, which favorable for DC capturing antigens maturation. Hence, strategy combined irradiation vaccine may be a novel approach treating malignancies early metastasis. Methods To develop an...
Dendritic cell (DC) vaccine has been demonstrated to induce antitumor immunity in animal models. It shown that the efficiency of by DC is closely correlated with maturation status. The mature human DCs generated from peripheral blood mononuclear cells (PBMCs) presence granulocyte macrophage–colony-stimulating factor (GM-CSF), interleukin (IL)-4, and tumor necrosis (TNF)-α have widely contributed their growing use cancer vaccination trials. Although objective clinical immune responses...
Introduction: Fulvestrant has demonstrated efficacy in hormone receptor positive (HR+) metastatic breast cancer (mBC), both first-and second-line settings. In clinical practice, however, fulvestrant been used as a later-line therapy. This study assessed the of women with mBC early-versus Methods: retrospective cohort Saskatchewan HR+ who received between 2003–2019. A multivariate Cox proportional survival analysis was performed. Results: One hundred and eighty-six median age 63.5 years were...
6053 Background: Addition of concurrent anti-EGFR monoclonal antibody to radiotherapy alone did not worsen QOL (Curran 2007). We compared standard chemoradiotherapy (cRT) bioradiotherapy (bRT). Methods: Pts with T any N+M0 or T3-4N0M0 untreated LA-SCCHN were randomized 1:1 receive SFX (70Gy/35/7 weeks) plus CIS at 100 mg/m2intravenous (IV) for 3 doses on weeks 1, 4 and 7 versus AFX (70Gy/35/6 the PMab 9 mg/kg IV -1, 6. was collected baseline, end RT, 2, 4, 6, 12, 24 36 months post-RT using...
TNBC is associated with a high risk of local and distant recurrence diagnosed at relatively younger age. There paucity trials focusing on women ≥70 yrs TNBC. We aimed to determine the outcomes in relation age, residence, marital status independent known clinical variables. In this retrospective cohort study, early-stage operable invasive BC during 2010-2018 province Saskatchewan underwent curative surgery were included. A multivariate Cox proportional hazard model was performed. Various...
1571 Background: BC is uncommon in VYWAA (≤ 35 years) and accounts for about 1.8% of all BC. As screening typically recommended women aged 50-74 years there a risk delayed diagnosis especially those with rural residence. The current study aims to assess outcomes cohort relation their place residence the province Saskatchewan over period 20 years. Methods: In this population-based retrospective ≤ histologically documented epithelial during 2000-2019 were evaluated. Survival entire its...
Breast cancer is rare in men. This population-based study aimed to determine outcomes of male breast relation residence and other variables.In this retrospective cohort study, men diagnosed with Saskatchewan during 2000-2019 were evaluated. Cox proportional multivariable regression analyses performed the correlation between survival clinicopathological contextual factors.One hundred-eight eligible patients a median age 69 years identified. Of them, 16% had WHO performance status ≥ 2 61%...
<title>Abstract</title> <bold>Introduction:</bold> Fulvestrant has demonstrated efficacy in hormone receptor positive (HR+) metastatic breast cancer (mBC), both first- and second-line settings. In clinical practice, however, fulvestrant been used as a later-line therapy. The study aimed to assess the of women with mBC early- versus <bold>Methods: </bold>In this retrospective cohort study, HR+ who received between 2003–2019 Saskatchewan were assessed. A multivariate Cox proportional survival...
Abstract: Nodal ratio (NR) is defined as the number of involved nodes to examined. There limited information on application NR population data. Previous reports in breast cancer generally analyzed one three positive axillary a single group. This study investigates whether homogeneous group prognosis by comparing two nodes. The population-based registry Canadian province from 1981 through 1995 was searched. As reliability nodal assessment depends sampled, we also studied subgroup patients...