A5031011115- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Renal and related cancers
- Esophageal Cancer Research and Treatment
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Cancer Genomics and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Metabolomics and Mass Spectrometry Studies
- Colorectal Cancer Screening and Detection
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Tuberous Sclerosis Complex Research
- Multiple and Secondary Primary Cancers
- Health Systems, Economic Evaluations, Quality of Life
- Pediatric Urology and Nephrology Studies
- Genetic and Kidney Cyst Diseases
- Advanced Radiotherapy Techniques
- Advanced MRI Techniques and Applications
- Cell Adhesion Molecules Research
- Global Cancer Incidence and Screening
Harvard University
2016-2025
Massachusetts General Hospital
2016-2025
Brigham and Women's Hospital
2016-2024
Johns Hopkins Medicine
2023
Johns Hopkins University
2023
University of Exeter
2020-2021
MGH Institute of Health Professions
2020
GTx (United States)
2019
Memorial Sloan Kettering Cancer Center
2018
Olympus (Japan)
2018
Renal cell carcinoma (RCC) occurs in 2% to 4% of patients with tuberous sclerosis complex (TSC). Previous reports have noted a variety histologic appearances these cancers, but the full spectrum morphologic and molecular features has not been fully elucidated. We encountered 46 renal epithelial neoplasms from 19 TSC analyzed their clinical, pathologic, features, enabling separation tumors into 3 groups. The largest subset (n=24) had distinct morphologic, immunologic, profile, including...
Translocation renal cell carcinoma (tRCC) is a poorly characterized subtype of kidney cancer driven by MiT/TFE gene fusions. Here, we define the landmarks tRCC through an integrative analysis 152 patients with identified across genomic, clinical trial, and retrospective cohorts. Most tRCCs harbor few somatic alterations apart from fusions homozygous deletions at chromosome 9p21.3 (19.2% cases). Transcriptionally, display heightened NRF2-driven antioxidant response that associated resistance...
Purpose Prostate-specific antigen (PSA) level in midlife predicted future prostate cancer (PCa) mortality an unscreened Swedish population. Our purpose was to determine if a baseline PSA during predicts lethal PCa US population with opportunistic screening. Materials and Methods We conducted nested case-control study among men age 40 59 years who gave blood before random assignment the Physicians’ Health Study, randomized, placebo-controlled trial of aspirin β-carotene 22,071 male physicians...
To evaluate the effectiveness, cost, and cost-effectiveness of using renal mass biopsy to guide treatment decisions for small incidentally detected tumors.
Objective: We describe the first successful penis transplant in United States a patient with history of subtotal penectomy for penile cancer. Background: Penis transplantation represents new paradigm restoring anatomic appearance, urine conduit, and sexual function after genitourinary tissue loss. To date, only 2 transplants have been performed worldwide. Methods: After institutional review board approval, extensive medical, surgical, radiological evaluations were performed. His candidacy...
Importance The BCG vaccine—used worldwide to prevent tuberculosis—confers multiple nonspecific beneficial effects, and intravesical vaccine is currently the recommended treatment for non–muscle-invasive bladder cancer (NMIBC). Moreover, has been hypothesized reduce risk of Alzheimer disease related dementias (ADRD), but previous studies have limited by sample size, study design, or analyses. Objective To evaluate whether exposure associated with a decreased incidence ADRD in cohort patients...
Abstract Purpose: Using proteomic techniques, we sought to identify novel protein biomarkers in tissue and urine from patients with transitional cell carcinoma (TCC). Experimental Design: Urinary proteomes were analyzed differentially expressed proteins identified by mass spectrometry. One of the proteins, cystatin B, was further TCC immunohistochemistry semiquantitative Western blot analysis. Results: Cystatin B staining intensity significantly increased concordantly grade (P = 0.0008)....
Strigolactones are a novel class of plant hormones produced in roots and regulate shoot root development. We have previously shown that synthetic strigolactone analogues potently inhibit growth breast cancer cells stem cells. Here we show the survival an array cancer-derived cell lines representing solid non-solid including: prostate, colon, lung, melanoma, osteosarcoma leukemic lines, while normal were minimally affected. Treatment with was hallmarked by activation stress-related MAPKs: p38...
Younger patients with bladder cancer typically have fewer environmental exposures or risk factors, suggesting molecular pathways implicated in early-onset disease differ from older patients. Dissecting the genomic profile of tumors may define targeted treatments for these young We compared frequency somatic mutations cancer, defined as diagnosis before age 55 years old which encompasses about 1 10 diagnoses, two cohorts: Mass General Brigham Young Cystectomy Cohort (MGB-YCC, n=134 patients)...