A5062503540- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Renal and related cancers
- CAR-T cell therapy research
- Lung Cancer Research Studies
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Neural dynamics and brain function
- Fungal Infections and Studies
- Respiratory viral infections research
- Neuroendocrine Tumor Research Advances
- Pneumonia and Respiratory Infections
- Emergency and Acute Care Studies
- Racial and Ethnic Identity Research
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Multiple Myeloma Research and Treatments
- Lung Cancer Treatments and Mutations
- Chromatin Remodeling and Cancer
- Renin-Angiotensin System Studies
- Attention Deficit Hyperactivity Disorder
- Bacterial Infections and Vaccines
Brigham and Women's Hospital
2021-2023
Harvard University
2021-2023
Newcastle University
2023
University of Massachusetts Amherst
2023
Dana-Farber Cancer Institute
2023
Royal Alexandra Children's Hospital
2022
Dartmouth College
2014
Translocation renal cell carcinoma (tRCC) is a poorly characterized subtype of kidney cancer driven by MiT/TFE gene fusions. Here, we define the landmarks tRCC through an integrative analysis 152 patients with identified across genomic, clinical trial, and retrospective cohorts. Most tRCCs harbor few somatic alterations apart from fusions homozygous deletions at chromosome 9p21.3 (19.2% cases). Transcriptionally, display heightened NRF2-driven antioxidant response that associated resistance...
Some small cell lung cancers (SCLCs) are highly sensitive to inhibitors of the histone demethylase LSD1. LSD1 thought induce their anti-proliferative effects by blocking neuroendocrine differentiation, but mechanisms which controls SCLC phenotype not well understood. To identify genes required for inhibitor sensitivity in SCLC, we performed a positive selection genome-wide CRISPR/Cas9 loss function screen and found that ZFP36L1, an mRNA-binding protein destabilizes mRNAs, is sensitivity....
Suicide prevention is a national priority for the UK government. Autistic people are at greater risk of experiencing self-harm and suicidal thoughts behaviours than general population. Safety plans widely used in suicide but have not yet been designed with autistic people. We developed first safety plan specifically targeting suicidality adults: Autism Adapted Plan (AASP). It consists prioritised list hierarchical steps that can be prior to or during crisis mitigate behaviour. This pilot...
Abstract Purpose: Programmed cell death protein 1 (PD-1) expression on CD8+TIM-3−LAG-3− tumor-infiltrating cells predicts positive response to PD-1 blockade in metastatic clear-cell renal carcinoma (mccRCC). Because inhibition of signaling regulatory T (Treg) augments their immunosuppressive function, we hypothesized that Tregs would predict resistance inhibitors. Experimental Design: PD-1+ were phenotyped using multiparametric immunofluorescence ccRCC tissues from the CheckMate-025 trial...
Abstract Neuroendocrine to nonneuroendocrine plasticity supports small cell lung cancer (SCLC) tumorigenesis and promotes immunogenicity. Approximately 20% 25% of SCLCs harbor loss-of-function (LOF) NOTCH mutations. Previous studies demonstrated that functions as a SCLC tumor suppressor, but can also drive support growth. Given the dual functionality NOTCH, it is not understood why select for LOF mutations how these affect tumorigenesis. In CRISPR-based genetically engineered mouse model...
Inactivation of the VHL tumor suppressor gene is signature initiating event in clear cell renal carcinoma (ccRCC), which most common form kidney cancer. The protein marks hypoxia-inducible factor 1 (HIF1) and HIF2 for proteasomal degradation when oxygen present. inappropriate accumulation drives formation by (pVHL)–defective ccRCC. Belzutifan, a first-in-class allosteric inhibitor, has advanced to phase 3 testing ccRCC approved ccRCCs arising patients with disease, caused germline mutations....
Abstract Purpose: PD-L1 expression on tumor cells (TC) is associated with response to anti-PD-1-based therapies in some types, but its significance clear cell renal carcinoma (ccRCC) uncertain. We leveraged heterogeneity identify molecular correlates of TC ccRCC and assessed their role predicting anti-PD-1 monotherapy. Experimental Design: RNA sequencing was performed paired positive negative areas isolated from eight tumors transcriptomic features status were identified. A cohort 232...
Abstract Background Streptococcus pneumoniae is a global cause of community-acquired pneumonia (CAP) and invasive disease in children. The CAP-IT trial (grant No. 13/88/11; https://www.capitstudy.org.uk/ ) collected nasopharyngeal swabs from children discharged hospitals with clinically diagnosed CAP, found no differences pneumococci susceptibility between higher lower antibiotic doses shorter longer durations oral amoxicillin treatment. Here, we studied in-depth the genomic epidemiology...
Abstract Purpose: Antiangiogenic VEGF receptor (VEGFR) inhibitors are approved for metastatic clear cell renal carcinoma (mccRCC) and their efficacy is higher in high angiogenic tumors. As cabozantinib inhibits multiple tyrosine kinase receptors, including VEGFRs, we tested whether markers of angiogenesis, microvascular density (MVD) mast (MCD), could predict benefit from versus everolimus, using RCC samples the METEOR (NCT01865747) trial. Experimental Design: MVD MCD were studied 430...
Interventions introduced to reduce the spread of SARS-CoV-2 led a widespread reduction in childhood infections. However, from spring 2021 onwards United Kingdom and Ireland experienced an unusual out-of-season epidemic respiratory disease.
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<div>AbstractPurpose:<p>Programmed cell death protein 1 (PD-1) expression on CD8<sup>+</sup>TIM-3<sup>−</sup>LAG-3<sup>−</sup> tumor-infiltrating cells predicts positive response to PD-1 blockade in metastatic clear-cell renal carcinoma (mccRCC). Because inhibition of signaling regulatory T (Treg) augments their immunosuppressive function, we hypothesized that Tregs would predict resistance inhibitors.</p>Experimental...
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