A5009003275- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Emergency and Acute Care Studies
- Child and Adolescent Health
- Sepsis Diagnosis and Treatment
- Delphi Technique in Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Stress Responses and Cortisol
- Cardiac, Anesthesia and Surgical Outcomes
- Cystic Fibrosis Research Advances
- Food Allergy and Anaphylaxis Research
- Health Sciences Research and Education
- Allergic Rhinitis and Sensitization
- Autoimmune Bullous Skin Diseases
- Liver Disease Diagnosis and Treatment
- Urticaria and Related Conditions
- Intestinal Malrotation and Obstruction Disorders
- Autoimmune and Inflammatory Disorders
- Congenital Diaphragmatic Hernia Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ion channel regulation and function
- Hormonal Regulation and Hypertension
- Inhalation and Respiratory Drug Delivery
Wirral University Teaching Hospital NHS Foundation Trust
2010-2022
Arrowe Park Hospital
2014-2022
Noah's Ark Children's Hospital for Wales
2018
Cardiff and Vale University Health Board
2018
Birmingham Children's Hospital
1993
Children's Hospital
1993
Children's of Alabama
1993
Heartlands Hospital
1993
Abstract Background Peanut allergy is classically managed by food avoidance. Immunotherapy programs are available at some academic centers for selected patients reacting to small amounts of peanut during challenge. We aimed determine and compare reaction thresholds prevalence anaphylaxis oral challenges multiple specialist centers. Methods A retrospective, international survey anonymized case records from seven pediatric the UK Ireland, as well Australian HealthNuts study. Demographic...
To examine serum cortisol responses to a simplified low-dose short Synacthen test (LDSST) in children treated with inhaled corticosteroids (ICS) for asthma and compare these early morning salivary (EMSC) cortisone (EMSCn) levels.Early EMSCn samples were collected three consecutive days. On day three, 500 ng/1·73 m(2) was administered intravenously. Samples at 0, 15, 25, 35 min.A total of 269 subjects (160 M: 109 F), median (range) age 10·0 (5·1-15·2) years studied. Peak the LDSST <500 nmol/l...
Extra-intestinal or metastatic Crohn9s disease is being recognised increasingly, most commonly in the skin and genitourinary system. Only very rarely has it been reported lung. A 3 year old boy who presented with swollen gums a persistent abnormality on his chest x ray reported. Lung biopsy specimens showed multiple non-caseating epithelioid granulomas. Subsequent investigation presence of intestinal disease. The evidence for abnormal lung function possible pathogenesis pulmonary are discussed.
In hospital, staff need to routinely monitor patients identify those who are seriously ill, so that they receive timely treatment improve their condition. A Paediatric Early Warning System is a multi-faceted socio-technical system detect deterioration in children, which may or not include track and trigger tool. It functions monitor, prompt an urgent response signs of deterioration, with the aim preventing morbidity mortality. The purpose this study develop evidence-based improvement...
Paediatric mortality rates in the United Kingdom are amongst highest Europe. Clinically missed deterioration is a contributory factor. Evidence to support any single intervention address this problem limited, but cumulative body of research highlights need for systems approach. An evidence-based, theoretically informed, paediatric early warning system improvement programme (PUMA Programme) was developed and implemented two general hospitals (no onsite Intensive Care Unit) tertiary (with...
Interventions introduced to reduce the spread of SARS-CoV-2 led a widespread reduction in childhood infections. However, from spring 2021 onwards United Kingdom and Ireland experienced an unusual out-of-season epidemic respiratory disease.
Bronchiolitis is an acute lower respiratory infection which predominantly affects young children. Treatment for bronchiolitis limited to supportive therapy. Nasal oxygen therapy part of routine care, and delivery now incorporates varying levels non-invasive continuous positive airway pressure and/or high-flow nasal cannula Despite wide clinical use, there remains a lack evidence on the comparative effectiveness safety these interventions. Furthermore, research in this field hampered by use...
Background Bronchiolitis is a major cause of admission to hospital in children. Non-invasive ventilation (NIV) support with continuous positive airway pressure (CPAP) or high-flow nasal cannula (HFNC) oxygen routinely used for infants the UK bronchiolitis. Objective To establish paediatric practice regarding management bronchiolitis, and explore issues pertinent design potential future randomised controlled trial NIV. Design Screening logs were completed hospitals England capturing...
<b>Background:</b> Oxygen (O<sub>2</sub>) is a mainstay of treatment in acute severe asthma. While there are physiological reasons why O<sub>2</sub> should be warmed and humidified, how administered the UK Europe varies widely. <b>Aim:</b> To examine whether trial comparing different humidified to standard feasible, specifically obtain data on accrual, adherence outcome measure stability. <b>Methods:</b> Children 2-16yrs attending A&E with severe/life-threatening asthma (according...
Background The Paediatric early warning system Utilisation and Morbidity Avoidance (PUMA) study was commissioned to develop, implement evaluate a paediatric track-and-trigger tool for widespread adoption. Following findings from three systematic reviews, revised aims focused on implementation of whole-systems improvement programme. Objectives (1) Identify, through review, the following: evidence core components effective tools systems, contextual factors consequential effectiveness. (2)...