A5048550515- Lung Cancer Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Computational Drug Discovery Methods
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Statistical Methods in Clinical Trials
- Cardiac electrophysiology and arrhythmias
- Cancer, Hypoxia, and Metabolism
- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- MRI in cancer diagnosis
- Prostate Cancer Diagnosis and Treatment
- Mathematical Biology Tumor Growth
- Atomic and Subatomic Physics Research
- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- Neuroendocrine Tumor Research Advances
- Advances in Oncology and Radiotherapy
- Health Systems, Economic Evaluations, Quality of Life
- Gastric Cancer Management and Outcomes
Osys Technology
2025
University of Manchester
2015-2024
The Christie NHS Foundation Trust
2018-2024
Cancer Research UK Manchester Institute
2018-2024
Manchester Academic Health Science Centre
2017-2023
Boehringer Ingelheim (Austria)
2023
Clatterbridge Cancer Centre NHS Foundation Trust
2023
University of Reading
2023
Age UK
2023
Mott MacDonald (Czechia)
2021
Abstract Objective To investigate the effects of Image Biomarker Standardisation Initiative (IBSI) compliance, harmonisation calculation settings and platform version on statistical reliability radiomic features their corresponding ability to predict clinical outcome. Methods The was assessed retrospectively in three datasets (patient numbers: 108 head neck cancer, 37 small-cell lung 47 non-small-cell cancer). Features were calculated using four platforms (PyRadiomics, LIFEx, CERR IBEX)....
Bladder-sparing trimodal therapy (TMT) is an alternative to radical cystectomy (RC) according international guidelines. However, there are limited data guide management of nonmetastatic clinically node-positive bladder cancer (cN+ M0 BCa). We performed a multicenter retrospective analysis survival outcomes in patients inform practice.
IntroductionCONVERT was a phase 3 international randomized clinical trial comparing once-daily (OD) and twice-daily (BD) radiation therapy (RT). This updated analysis describes the 6.5 year outcomes of these regimes delivered with conformal techniques.MethodsCONVERT (NCT00433563) patients 1:1 between OD RT (66 Gy/33 fractions/6.5 weeks) BD (45 Gy/30 fractions/3 both concurrent cisplatin/etoposide. Three-dimensional mandatory, intensity-modulated permitted, elective nodal irradiation not...
Cell lines expressing ion channels (IC) and the advent of plate-based electrophysiology device have enabled a molecular understanding action potential (AP) as means early QT assessment. We sought to develop an in silico AP (isAP) model that provides assessment effect compound on myocyte duration (APD) using concentration-effect curve data from panel five ICs (hNav1.5, hCav1.2, hKv4.3/hKChIP2.2, hKv7.1/hminK, hKv11.1). A test set 53 compounds was selected cover range selective mixed IC...
Hypoxia is associated with poor prognosis and predictive of response to cancer treatments, including radiotherapy. Developing noninvasive biomarkers that both detect hypoxia prior treatment track change in tumor following required urgently.
Developing pharmacokinetic-pharmacodynamic (PK-PD) models requires a significant amount of time from highly skilled scientists and the demand for this expertise far outstrips current supply. The use machine learning (ML) artificial intelligence (AL) in PK-PD modeling promises to reduce number human supervision hours improve predictive performance, but its form it suffers various limitations. In perspective, we aimed structure main trends define boundaries opportunities. modelers leverage...
There is limited evidence to guide stage I II small cell lung cancer (SCLC) treatment.
Abstract Background Peanut allergy is classically managed by food avoidance. Immunotherapy programs are available at some academic centers for selected patients reacting to small amounts of peanut during challenge. We aimed determine and compare reaction thresholds prevalence anaphylaxis oral challenges multiple specialist centers. Methods A retrospective, international survey anonymized case records from seven pediatric the UK Ireland, as well Australian HealthNuts study. Demographic...
Assessing the risk of resistance associated with biocide exposure commonly involves exposing microorganisms to biocides at concentrations close MIC. With aim representing environmental residues,
Prediction of clinical complete response in rectal cancer before neoadjuvant chemo-radiotherapy treatment enables selection. Patients predicted to have could chemo-radiotherapy, and others additional doublet chemotherapy at this stage their improve overall outcome. This work investigates the role variables predicting response. Using UK-based OnCoRe database (2008 2019), we performed a propensity-score matched study 322 patients who received chemoradiotherapy. We collected pre-treatment...
There is a need to refine the selection of patients with oropharyngeal squamous cell carcinoma (OPSCC) for treatment de-escalation. We investigated whether pretreatment absolute lymphocyte count (ALC) predicted overall survival (OS) benefit from addition concurrent chemotherapy radical radiotherapy.
ABSTRACT The antitumor efficacy of an intratumoral injection a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT ‐bearing mice. In the mouse model, combination hIL‐7/mIL‐12‐VV plus anti‐programmed cell death protein (PD)‐1 antibody determined to be correlated with timing administration: greater observed when administered before anti‐PD‐1 agent instead simultaneous administration. To identify optimal dosing...
Abstract Interleukin-12 (IL-12) mediates innate and adaptive immune responses has demonstrated therapeutic anti-tumor activity but clinical development been hindered by a narrow window. We generated novel IL-12 anchored-drug conjugate physiochemical linking of murine to aluminum hydroxide (alum). The complex was designed utilize alum as scaffolding for durable retention within the tumor microenvironment strategy increase To better define systemic PK profile anchored (mANK-101), model-based...
We propose a translational PK/PD framework that enables human dose estimation (HDE), compound ranking and to assess the clinical applicability of cancer cell-line-panels. Translational simulations were performed estimate efficacious doses in humans. The approach was first calibrated using an approved therapy, Trametinib. Cobimetinib Binimetinib then used as test compounds. for benchmarked against Trametinib aid HDE. modelling qualified reported Cobimetinib. population PK (PopPK) models...
Faithful separation of chromosomes prior to cell division at mitosis is a highly regulated process. One family serine/threonine kinases that plays central role in regulation the Aurora family. B spindle assembly checkpoint, part, by destabilizing localization BubR1 and Mad2 centrosomes responds changes tension caused aberrant microtubule kinetochore attachments. overexpressed subset cancers required for mitosis, making it an attractive anticancer target. Here, we use mathematical modeling...
There is a lack of data on the efficacy and safety concurrent chemoradiotherapy in elderly, limited-stage, patients with SCLC.We compared outcomes 70 years age or older versus younger within Concurrent Once-daily Versus twice-daily RadioTherapy (CONVERT) trial. Patients were randomized to receive 45 Gy/30 fractions/19 days 66 Gy/33 once-daily fractions/45 concurrently platinum-based chemotherapy. Overall survival progression-free evaluated using Kaplan-Meier methodology Cox proportional...
BC2001 showed combining chemotherapy (5-FU + mitomycin-C) with radiotherapy improves loco-regional disease-free survival in patients muscle-invasive bladder cancer (MIBC). We previously a 24-gene hypoxia-associated signature predicted benefit from hypoxia-modifying radiosensitisation BCON and hypothesised that only low hypoxia scores (HSs) would BC2001. allowed conventional (64Gy/32 fractions) or hypofractionated (55Gy/20 radiotherapy. An exploratory analysis tested an additional hypothesis...