A5015749853- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Eosinophilic Esophagitis
- Contact Dermatitis and Allergies
- Drug-Induced Adverse Reactions
- Respiratory and Cough-Related Research
- Immunodeficiency and Autoimmune Disorders
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Dermatology and Skin Diseases
- Child Nutrition and Feeding Issues
- Urticaria and Related Conditions
- Pneumocystis jirovecii pneumonia detection and treatment
- Mast cells and histamine
- Pharmaceutical studies and practices
- Transgenic Plants and Applications
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Bacterial Infections and Vaccines
- Platelet Disorders and Treatments
- Vaccine Coverage and Hesitancy
- Clinical Reasoning and Diagnostic Skills
- Consumer Attitudes and Food Labeling
- Milk Quality and Mastitis in Dairy Cows
University Hospital Southampton NHS Foundation Trust
2014-2025
Southampton Children's Hospital
2011-2025
University of Southampton
2011-2025
Southampton General Hospital
2000-2018
Royal Children's Hospital
2011
Southampton City Council
2009
Hampton University
2009
Bristol Royal Hospital for Children
2008
University of Bristol
2006-2007
At Bristol
2003
No approved treatment for peanut allergy exists children younger than 4 years of age, and the efficacy safety epicutaneous immunotherapy with a patch in toddlers are unknown. We conducted this phase 3, multicenter, double-blind, randomized, placebo-controlled trial involving 1 to 3 age confirmed by food challenge. Patients who had an eliciting dose (the necessary elicit allergic reaction) 300 mg or less protein were assigned 2:1 ratio receive delivered means (intervention group) placebo...
Cummings AJ, Knibb RC, Erlewyn-Lajeunesse M, King RM, Roberts G, Lucas JSA. Management of nut allergy influences quality life and anxiety in children their mothers.Pediatr Allergy Immunol 2010: 21: 586–594.© 2010 John Wiley & Sons A/S Nut is known to impact on the (QoL) both allergic child parents, but little about how management food associated with these variables. To investigate QoL mothers order identify strategies that may influence factors. Forty-one (age 6–16 yrs) completed...
The peak incidence of deaths from anaphylaxis associated with nut allergy occurs in teenagers and young adults. During adolescence, the management food shifts being responsibility parents to that person. This is a group who therefore need special attention clinic.This study aimed understand practical challenges experience using qualitative approach generate potential interventions for tackling these.Teenagers aged 1118 years completed questionnaire about their underwent focused,...
The prevalence and time trends of food allergy change during childhood depending on the age child type food.To study longitudinal in from birth to 18 years an unselected cohort Isle Wight.Information was collected at ages 1, 2, 4, 10 Wight Birth Cohort (n = 1456). Skin prick testing (SPT) performed 1 2 symptomatic children. At age, participants were tested a panel aeroallergens. Food diagnosed based criteria: symptoms suggestive typical IgE-mediated reaction <4 hours following exposure known...
How safe is live attenuated influenza vaccine (LAIV), which contains egg protein, in young people with allergy?In this open label, phase IV intervention study, 779 (2-18 years) allergy were recruited from 30 UK centres and immunised LAIV. The cohort included 270 (34.7%) previous anaphylaxis to egg, of whom 157 (20.1%) had experienced respiratory and/or cardiovascular symptoms. 445 (57.1%) doctor diagnosed asthma or recurrent wheeze. Participants observed for at least minutes after...
This guideline advises on the management of patients with egg allergy. Most commonly allergy presents in infancy, a prevalence approximately 2% children and 0.1% adults. A clear clinical history will confirm diagnosis most cases. Investigation by measuring egg-specific IgE (by skin prick testing or specific assay) is useful moderate-severe cases where there diagnostic uncertainty. Following an acute allergic reaction, avoidance advice should be provided. Egg usually resolves, reintroduction...
BackgroundLive attenuated influenza vaccine (LAIV) is an intranasal recently incorporated into the United Kingdom immunization schedule. However, it contains egg protein and, in absence of safety data, contraindicated patients with allergy. Furthermore, North American guidelines recommend against its use asthmatic children.ObjectiveWe sought to assess LAIV children allergy.MethodsWe performed a prospective, multicenter, open-label, phase IV intervention study involving 11 secondary/tertiary...
Previous studies provide evidence for an association between modifications of the gut microbiota in early life and development food allergies. We studied faecal composition (16S rRNA gene amplicon sequencing) microbiome functionality (metaproteomics) a cohort 40 infants diagnosed with cow's milk allergy (CMA) when entering study. Some showed outgrowth CMA after 12 months, while others did not. Faecal was analysed directly diagnosis (baseline) as well 6 months The aim to gain insight on...
Pediatricians are often the first point of contact for children in Primary Care (PC), but still perceive gaps their allergy knowledge. We investigated self-perceived knowledge and educational needs pediatricians across healthcare systems Europe so that future initiatives may better support delivery services PC.
Twenty percent of children outgrow peanut allergy and 10% tree nut allergy. Resolution can be confirmed by a food challenge. Little is known about the psychosocial impact We aimed to investigate effects challenge on anxiety, stress quality life (QoL) in their mothers day peanuts or nuts, months following challenge.One hundred three families participated. Forty undergoing challenges access resolution allergy, mothers, completed validated questionnaires measure generic specific life, anxiety...
Abstract Background Peanut allergy is classically managed by food avoidance. Immunotherapy programs are available at some academic centers for selected patients reacting to small amounts of peanut during challenge. We aimed determine and compare reaction thresholds prevalence anaphylaxis oral challenges multiple specialist centers. Methods A retrospective, international survey anonymized case records from seven pediatric the UK Ireland, as well Australian HealthNuts study. Demographic...
There is an unmet need for specialist allergy treatment in the United Kingdom. Allergen immunotherapy and with omalizumab chronic spontaneous urticaria (CSU) are key markers these services. The British Society Allergy Clinical Immunology (BSACI) Registry Immunotherapy (BRIT) a national project to record real-world effectiveness, safety access aero-allergen, venom peanut as well CSU. We described participant demographics, index of multiple deprivation (IMD) from registry launch. Data 1835...
A randomised open label study of the combined use paracetamol and ibuprofen to rapidly reduce fever is reported. The advantage using both medications less than half a degree centigrade in first hour, insufficient warrant routine use.
<b>Anaphylaxis is a rare</b> adverse event following immunisation (AEFI) and unlikely to be detected in prelicensure vaccine trials. Previous retrospective studies have been hampered by the paucity of information available passive reporting schemes. The aim present study was estimate incidence clinical presentation anaphylaxis as an AEFI using prospective active surveillance. <h3>Methods</h3> Children under 16 UK Ireland with suspected were reported through British Paediatric Surveillance...