A5010156236- Pneumonia and Respiratory Infections
- Infective Endocarditis Diagnosis and Management
- Respiratory viral infections research
- Streptococcal Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Infections and Vaccines
- Gut microbiota and health
- Mast cells and histamine
- Asthma and respiratory diseases
- Milk Quality and Mastitis in Dairy Cows
- Antibiotic Resistance in Bacteria
- Aquaculture disease management and microbiota
- IL-33, ST2, and ILC Pathways
- Probiotics and Fermented Foods
- Escherichia coli research studies
- Enterobacteriaceae and Cronobacter Research
- Urticaria and Related Conditions
- Vibrio bacteria research studies
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Neonatal and Maternal Infections
- Identification and Quantification in Food
- Clostridium difficile and Clostridium perfringens research
- Microbial Inactivation Methods
University of Antwerp
2020-2025
The optimal dose and duration of oral amoxicillin for children with community-acquired pneumonia (CAP) are unclear.To determine whether lower-dose is noninferior to higher 3-day treatment 7 days.Multicenter, randomized, 2 × factorial noninferiority trial enrolling 824 children, aged 6 months older, clinically diagnosed CAP, treated on discharge from emergency departments inpatient wards 28 hospitals in the UK 1 Ireland between February 2017 April 2019, last visit May 21, 2019.Children were...
Many European countries have recently reported upsurges in invasive group A Streptococcus (iGAS) infections, mainly caused by emm1 pyogenes, specifically the toxigenic M1UK lineage. We present epidemiology of causing iGAS Belgium during 2018-August 2023, and describe an emergence lineage mid-2022 that was observed as increase bloodstream infections S. pyogenes continued into 2023.
The current study shows the relevance of Mas-related G protein-coupled receptor b2 (Mrgprb2)-dependent, pseudoallergic mast cell activation in mouse colon and positions it a novel SP-Mrgprb2 neuro-immune axis.Moreover, Mrgprb2 signaling acts as an integral part dextran sodium sulphate-induced colonic mucosal damage response.BACKGROUND & AIMS: Mast cells (MCs) are typically found at surfaces, where their immunoglobulin E (IgE)-dependent plays central role allergic diseases.Over past years,...
ABSTRACT Streptococcus pneumoniae serotype 23B, a non-vaccine serotype, has shown an increasing prevalence and penicillin non-susceptibility among carriage invasive pneumococcal disease (IPD) isolates. Recently, novel non-susceptible genotype emerged, named 23B1. In the framework of Belgian study, we studied 23B 0 /23B1 586 strains (2016–2022) in 172 day care centers from 6- to 30-month-old children 130 pediatric IPD isolates (2007–2021). Pneumococci were whole genome sequenced determine...
Background Klebsiella pneumoniae ST101 is an emerging high-risk clone which exhibits extensive drug resistance. Bacterial strains residing in multiple hosts show unique signatures related to host adaptation. In this study, we assess the genetic relationship of K. isolated from hospital samples, environment, community, and livestock using whole genome sequencing (WGS). Materials Methods We selected ten hospitalized patients Italy ( n = 3) (2014) Spain 5) (2015–2016) as well Belgian animals 2)...
The influence of gut microbiota on host immunity is widely studied, and its disturbance has been linked to several immune-mediated disorders. Conversely, whether how inherently disturbed canonical Th1 (pro-inflammatory) and/or Th2 (anti-inflammatory) immune pathways modify the microbiome not sufficiently investigated. Here, we characterized humoral, cellular, cytokine immunity, associated alterations in naïve wild-type mice (C57BL/6 BALB/c), with deficiencies responses (IL-4Rα IL-33 knockout...
Background Non-typeable Haemophilus influenzae has become increasingly important as a causative agent of invasive diseases following vaccination against H. type b. The emergence antibiotic resistance underscores the necessity to investigate typeable non-b carriage and non-typeable (NTHi) in children. Methods Nasopharyngeal swab samples were taken over three-year period (2016–2018) from 336 children (6–30 months age) attending daycare centers (DCCs) Belgium, 218 with acute otitis media (AOM)....
Abstract Background Streptococcus pneumoniae is a global cause of community-acquired pneumonia (CAP) and invasive disease in children. The CAP-IT trial (grant No. 13/88/11; https://www.capitstudy.org.uk/ ) collected nasopharyngeal swabs from children discharged hospitals with clinically diagnosed CAP, found no differences pneumococci susceptibility between higher lower antibiotic doses shorter longer durations oral amoxicillin treatment. Here, we studied in-depth the genomic epidemiology...
Urinary tract infections (UTIs) are one of the main reasons for antibiotic prescriptions in primary care. Recent studies demonstrate similar clinical outcomes with short vs. long antibiotics courses. The aim this study was to investigate differential collateral effect ciprofloxacin treatment duration on gastrointestinal and oropharyngeal microbiome patients presenting uncomplicated UTI care practices Switzerland, Belgium Poland.