A5023141945- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Cancer Immunotherapy and Biomarkers
- Antibiotic Resistance in Bacteria
- Gut microbiota and health
- Cystic Fibrosis Research Advances
- Vibrio bacteria research studies
- CAR-T cell therapy research
- Long-Term Effects of COVID-19
- Yersinia bacterium, plague, ectoparasites research
- Evolution and Genetic Dynamics
- Immune Response and Inflammation
- Sinusitis and nasal conditions
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Peptidase Inhibition and Analysis
- Bacterial biofilms and quorum sensing
- Allergic Rhinitis and Sensitization
- Bacterial Infections and Vaccines
- Ocular Surface and Contact Lens
- Neuropeptides and Animal Physiology
- Respiratory Support and Mechanisms
- Nosocomial Infections in ICU
- Inhalation and Respiratory Drug Delivery
University of Antwerp
2019-2024
Infectious Diseases Institute
2019
Abstract It is well established that antibiotic treatment selects for resistance, but the dynamics of this process during infections are poorly understood. Here we map responses Pseudomonas aeruginosa to in high definition a lung infection single ICU patient. Host immunity and therapy with meropenem suppressed P. , second wave emerged due growth oprD wbpM resistant mutants evolved situ. Selection then led loss resistance by decreasing prevalence low fitness mutants, increasing frequency...
Abstract Bacteria have the potential to translocate between sites in human body, but dynamics and consequences of within-host bacterial migration remain poorly understood. Here we investigate link gut lung Pseudomonas aeruginosa populations an intensively sampled ICU patient using a combination genomics, isolate phenotyping, host immunity profiling, clinical data. Crucially, show that colonization was driven by translocation P. from gut. Meropenem treatment for suspected urinary tract...
BackgroundThe role of host immunity in emergence evasive SARS-CoV-2 Spike mutations under therapeutic monoclonal antibody (mAb) pressure remains to be explored.MethodsIn a prospective, observational, monocentric ORCHESTRA cohort study, conducted between March 2021 and November 2022, mild-to-moderately ill COVID-19 patients (n = 204) receiving bamlanivimab, bamlanivimab/etesevimab, casirivimab/imdevimab, or sotrovimab were longitudinally studied over 28 days for viral loads, de novo...
The influence of gut microbiota on host immunity is widely studied, and its disturbance has been linked to several immune-mediated disorders. Conversely, whether how inherently disturbed canonical Th1 (pro-inflammatory) and/or Th2 (anti-inflammatory) immune pathways modify the microbiome not sufficiently investigated. Here, we characterized humoral, cellular, cytokine immunity, associated alterations in naïve wild-type mice (C57BL/6 BALB/c), with deficiencies responses (IL-4Rα IL-33 knockout...
Mechanical ventilation (MV) is the primary risk factor for development of ventilator-associated pneumonia (VAP). Besides inducing a pro-inflammatory T-helper (Th)-1 cytokine response, MV also induces an anti-inflammatory Th2 marked by increased IL-4 secretion and reduced bacterial phagocytic capacity rodent lung macrophages. Since known to downregulate both Th1 Th17 cytokines, latter important in mediating mucosal immunity combating fungal growth, we studied showed here rat model that...
Cytokines, chemokines, and (angiogenic) growth factors (CCGs) have been shown to play an intricate role in the progression of both solid haematological malignancies. Recent studies that SARS-CoV-2 infection leads a worse outcome cancer patients, especially malignancy patients. Here, we investigated how impacts already altered CCG levels or malignancies, specifically, whether there is protective effect rather potentially higher risk for major COVID-19 complications patients due elevated CCGs...
Coronavirus disease 2019 (COVID-19) is a viral lower respiratory tract infection caused by the highly transmissible and pathogenic SARS-CoV-2 (severe acute respiratory-syndrome coronavirus-2). Besides failure, systemic thromboembolic complications are frequent in COVID-19 patients suggested to be result of dysregulation hemostatic balance. Although several markers coagulation fibrinolysis have been studied extensively, little known about effect on potent antifibrinolytic enzyme...
Abstract Current treatments fall short in managing allergic rhinitis (AR), emphasizing the need for additional strategies. Beneficial bacteria application shows promise AR, however most studies focus on oral probiotic administration without monitoring applied strains upper respiratory tract (URT) and their local effects. In this randomized, double-blind, placebo-controlled trial, Lacticaseibacillus rhamnosus GG was administered via chewable tablets seasonal AR patients, randomized to (n=33)...
Abstract Cytokines, chemokines and (angiogenic) growth factors (CCGs) have been shown to play an intricate role in the progression of both solid haematological malignancies. Recent studies that SARS-CoV-2 infection leads worse outcome cancer patients, especially malignancy patients. Here, we investigated how impacts already altered CCG levels or malignancies, specifically whether there is a protective effect rather potentially higher risk for major COVID-19 complications patients due...
ABSTRACT Biofilm dispersal is biologically significant process to fully understand its consequences during biofilm based infections. The mechanism for may involve response environmental cues and changes in intracellular secondary messengers. Considering range of dispersal, it study if dispersed cells generated by different methods have similar phenotype. In the present study, we compared four type P. aeruginosa environment (starvation nutrient rich), c-di-GMP knockdown signaling molecule NO....
Abstract Bacteria have the potential to migrate between sites in human body, but dynamics and consequences of within-host translocation remain poorly understood. Here we investigate link gut lung Pseudomonas aeruginosa populations an intensively sampled ICU patient using a combination genomics, isolate phenotyping, host immunity profiling, clinical data. Crucially, show that colonization was driven by repeated bacterial clones from gut. Meropenem treatment for suspected urinary tract...
Abstract The role of host immunity in emergence evasive SARS-CoV-2 Spike mutations under therapeutic monoclonal antibody (mAb) pressure remains to be explored. Here, we show that patients treated with various anti-SARS-CoV-2 mAb regimens develop remarkable speed and high specificity the targeted mAb-binding sites. Mutations more frequently immunocompromised strongly correlate not only neutralizing capacity mAbs, but also an anti-inflammatory healing-promoting milieu. Machine-learning models...
Patients with cancer, especially hematological are at increased risk for breakthrough COVID-19 infection. So far, a predictive biomarker that can assess compromised vaccine-induced anti-SARS-CoV-2 immunity in cancer patients has not been proposed. We employed machine learning approaches to identify signature based on blood cytokines, chemokines, and immune- non-immune-related growth factors linked vaccine immunogenicity 199 receiving the BNT162b2 vaccine. C-reactive protein (general marker...
A bstract Background Patients with cancer, especially haematological are at increased risk for breakthrough COVID-19 infection. However, so far, a predictive biomarker that can assess compromised vaccine-induced anti-SARS-CoV-2 immunity in cancer patients has not been proposed. Methods Here, we employed machine learning approaches to identify signature based on blood cytokine and growth factors linked vaccine response from 199 receiving BNT162b2 vaccine. Results We show C-reactive protein...