A5013803535- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- SARS-CoV-2 detection and testing
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Surgical site infection prevention
- COVID-19 diagnosis using AI
- Malaria Research and Control
- HIV Research and Treatment
- Mosquito-borne diseases and control
- Surgical Sutures and Adhesives
- Viral Infections and Vectors
- Shoulder Injury and Treatment
- Peripheral Nerve Disorders
- Streptococcal Infections and Treatments
- Enhanced Recovery After Surgery
- Viral Infections and Outbreaks Research
- Hepatitis C virus research
- Cardiac, Anesthesia and Surgical Outcomes
- Infection Control in Healthcare
- CAR-T cell therapy research
- Orthopedic Surgery and Rehabilitation
- Adolescent Sexual and Reproductive Health
- Infectious Diseases and Tuberculosis
University of Verona
2020-2024
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2012-2020
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2020
University Hospital Foundation
2020
National Center for Infectious Diseases
2016
National Institute for Medical Research
2016
University of Dar es Salaam
2016
Magna Graecia University
2015
National Institutes of Health
2013
Istituto Superiore di Sanità
1986-1997
Since the beginning of SARS-CoV-2 pandemic, COVID-19 appeared as a unique disease with unconventional tissue and systemic immune features. Here we show signature associated severity by integrating single-cell RNA-seq analysis from blood samples broncho-alveolar lavage fluids clinical, immunological functional ex vivo data. This is characterized lung accumulation naïve lymphoid cells expansion activation myeloid cells. Myeloid-driven suppression hallmark evolution, highlighting arginase-1...
Lack of specific definitions clinical characteristics, disease severity, and risk preventive factors post-COVID-19 syndrome (PCS) severely impacts research discovery new therapeutics drugs.This prospective multicenter cohort study was conducted from February 2020 to June 2022 in 5 countries, enrolling SARS-CoV-2 out- in-patients followed at 3-, 6-, 12-month diagnosis, with assessment biochemical features, antibody (Ab) response, Variant Concern (VoC), physical mental quality life (QoL)....
In 2010, 2012, 2013 and 2014 dengue outbreaks have been reported in Dar es Salaam, Tanzania. However, there is no comprehensive data on the risk of transmission country. The objective this study was to assess Salaam during epidemic.This cross-sectional conducted Tanzania outbreak 2014. involved Ilala, Kinondoni Temeke districts. Adult mosquitoes were collected using carbon dioxide-propane powered Mosquito Magnet Liberty Plus traps. each household compound, water-holding containers examined...
BackgroundThe role of host immunity in emergence evasive SARS-CoV-2 Spike mutations under therapeutic monoclonal antibody (mAb) pressure remains to be explored.MethodsIn a prospective, observational, monocentric ORCHESTRA cohort study, conducted between March 2021 and November 2022, mild-to-moderately ill COVID-19 patients (n = 204) receiving bamlanivimab, bamlanivimab/etesevimab, casirivimab/imdevimab, or sotrovimab were longitudinally studied over 28 days for viral loads, de novo...
ObjectiveTo use Multi-Criteria Decision Analysis (MCDA) to determine weights for eleven criteria in order prioritize COVID-19 non-critical patients admission hospital healthcare settings with limited resources.MethodsThe MCDA was applied two main steps: specification of prioritizing (and levels within each criterion); and determination the based on experts' knowledge experience managing patients, via an online survey. Criteria were selected available evidence a focus low- middle-income...
Surgical site infection (SSI) is a common post-operative complication causing significant morbidity and mortality. Many SSI occur after discharge from hospital. Post-discharge surveillance in low middle income countries needs to be improved.We conducted an observational cohort study Dodoma, Tanzania examine the sensitivity specificity of telephone calls detect hospital comparison gold standard clinician review. Women undergoing caesarean section were enrolled followed up for 30 days....
We investigated a dengue outbreak in Dar es Salaam, Tanzania, 2014, that was caused by virus (DENV) serotype 2. DENV infection present 101 (20.9%) of 483 patients. Patient age and location residence were associated with infection. Seven (4.0%) 176 patients co-infected malaria DENV.
Recent in-vitro data have shown that the activity of monoclonal antibodies (mAbs) targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) varies according to variant concern (VOC). No studies compared clinical efficacy different mAbs against Omicron VOC.The MANTICO trial is a non-inferiority randomised controlled comparing early treatments with bamlanivimab/etesevimab, casirivimab/imdevimab, and sotrovimab in outpatients aged 50 or older mild-to-moderate SARS-CoV-2 infection....
Abstract We conducted a seroprevalence survey among 500 healthy adult donors at Zanzibar National Blood Transfusion Services. Dengue virus IgG was 50.6% and independently associated with age urban residence. These data will aid in building surveillance, preparedness, response plan for dengue infections the Archipelago.
Intravenous (i.v.) artesunate is now the recommended first-line treatment of severe falciparum malaria in adults and children by WHO guidelines. Nevertheless, several cases haemolytic anaemia due to i.v. have been reported. This paper describes case an HIV-infected patient with who was diagnosed after oral artemether-lumefantrine. The presented fever, headache, arthromyalgia returning from Central African Republic where he had working. blood examination revealed acute renal failure,...
Abstract Background Surgical site infections are a leading cause of morbidity and mortality after caesarean section, especially in Low Middle Income Countries. We hypothesized that combined infection prevention control with antimicrobial stewardship joint program would decrease the rate post- section surgical at Obstetrics & Gynaecology Department Tanzanian tertiary hospital. Methods The intervention included: 1. formal on-job trainings on control; 2. evidence-based education resistance...
A major limitation of current predictive prognostic models in patients with COVID-19 is the heterogeneity population terms disease stage and duration. This study aims at identifying a panel clinical laboratory parameters that day-5 symptoms onset could predict progression hospitalized COVID-19.Prospective cohort on adult COVID-19. Patient-level epidemiological, clinical, data were collected fixed time-points: day 5, 10, 15 from onset. was defined as in-hospital death and/or transfer to ICU...
This study aimed to compare the clinical progression of COVID-19 in high-risk outpatients treated with monoclonal antibodies (mAb) bamlanivimab, bamlanivimab-etesevimab and casirivimab-imdevimab. is an observational, multi-centre, prospective conducted from 18 March 15 July 2021 eight Italian tertiary-care hospitals including mild-to-moderate receiving bamlanivimab (700 mg), (700-1400 mg) or casirivimab-imdevimab (1200-1200 mg). All patients were at high risk according Medicines Agency...
The vast majority of rabies deaths occur in developing countries and rural areas. Due to the absence surveillance lack reliable information, many endemic are not able assess their burden implement appropriate solutions. This study reports incidence animal bites considered at risk transmission, along with rates determinants adherence post-exposure prophylaxis (PEP) between 2008 2014 Dodoma Region, Tanzania. A retrospective analysis rabid transmission Regional Referral Hospital (DRRH) during...
Real-world data on early treatment of coronavirus disease 2019 (COVID-19) outpatients with newly approved therapies are sparse.To explore the pattern use monoclonal antibodies (mAbs)/antiviral for COVID-19 in non-hospitalized patients from England and Italy December 2021 to October 2022.Public national dashboards weekly mAb/antiviral and/or severe acute respiratory syndrome 2 (SARS-CoV-2) infection diagnoses Italian Medicines Agency, National Institute Health, Health Service UK Government...
HIV resistance affects virological response to therapy and efficacy of prophylaxis in mother-to-child-transmission. The study aims assess the prevalence primary pregnant women naïve antiretrovirals. Cross sectional baseline analysis a cohort + (HPW) enrolled entitled Antiretroviral Management Antenatal Natal Infection (AMANI, peace Kiswahili language). AMANI began May 2010 Dodoma, Tanzania. In this observational cohort, antiretroviral treatment was provided all from 28th week gestation until...
Prosthetic joint infection due to Mycobacterium tuberculosis is occasionally encountered in clinical practice. To the best of our knowledge, this first report a prosthetic complicated by psoas abscesses and secondary Addison disease. A 67-year-old immunocompetent Caucasian woman underwent total left hip arthroplasty because osteoarthritis. After 18 months, she revision for possible infection. Periprosthetic tissue specimens bacteria were negative, empirical antibiotic therapy was...
ABSTRACT Anti-tumor necrosis factor alpha (anti-TNF-α) is used in the treatment of rheumatic diseases not responsive to first-line regimens. Data on safety anti-TNF-α HIV-infected patients are scarce and conflicting. We describe a case septic shock multiorgan failure that occurred after etanercept initiation influenza vaccination an woman with rheumatoid arthritis.
In recent years, Nocardia farcinica has been reported to be an increasingly frequent cause of localized and disseminated infections in the immunocompromised patient. However, literature is limited. We report a case left thigh phlegmon caused by N. that occurred patient with Leprosy undergoing treatment prednisone for leprosy reaction. describe 54-year-old Italian man affected multi-bacillary leprosy. The had worked South America 11 years. Seven months after his return Italy, he was diagnosed...