A5033916697- Immune cells in cancer
- Adipose Tissue and Metabolism
- Histone Deacetylase Inhibitors Research
- COVID-19 Clinical Research Studies
- Metabolomics and Mass Spectrometry Studies
- HIV-related health complications and treatments
- Vitamin C and Antioxidants Research
- interferon and immune responses
- Ferroptosis and cancer prognosis
- Long-Term Effects of COVID-19
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Cardiovascular Health and Disease Prevention
- Virus-based gene therapy research
- Hippo pathway signaling and YAP/TAZ
- S100 Proteins and Annexins
- RNA Interference and Gene Delivery
- Adenosine and Purinergic Signaling
- SARS-CoV-2 and COVID-19 Research
University of Modena and Reggio Emilia
2025
University of Verona
2017-2023
University Hospital Foundation
2020
University of Parma
2020
University of Turin
2015
University of Siena
2005
BACKGROUND. Patients with coronavirus disease 2019 (COVID-19) develop pneumonia generally associated lymphopenia and a severe inflammatory response due to uncontrolled cytokine release. These mediators are transcriptionally regulated by the JAK/STAT signaling pathways, which can be disabled small molecules.
<h3>Background</h3> Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with an overall 5-year survival rate of less than 8%. New evidence indicates that PDAC cells release pro-inflammatory metabolites induce marked alteration normal hematopoiesis, favoring the expansion and accumulation myeloid-derived suppressor (MDSCs). We report here patients show increased levels both circulating tumor-infiltrating MDSC-like cells. <h3>Methods</h3> The frequency MDSC subsets in...
Since the beginning of SARS-CoV-2 pandemic, COVID-19 appeared as a unique disease with unconventional tissue and systemic immune features. Here we show signature associated severity by integrating single-cell RNA-seq analysis from blood samples broncho-alveolar lavage fluids clinical, immunological functional ex vivo data. This is characterized lung accumulation naïve lymphoid cells expansion activation myeloid cells. Myeloid-driven suppression hallmark evolution, highlighting arginase-1...
Myeloid cells can restrain antitumor immunity by metabolic pathways, such as the degradation of l-arginine, whose concentrations are regulated arginase 1 (ARG1) enzyme. Results from preclinical studies indicate important role arginine metabolism in pancreatic ductal adenocarcinoma (PDAC) progression, suggesting a potential for clinical application; however, divergent evolution ARG1 expression and function rodents humans has restricted translation. To overcome this dichotomy, here, we show...
Abstract Cancer induces alteration of hematopoiesis to fuel disease progression. We report that in tumor-bearing mice the macrophage colony-stimulating factor elevates myeloid cell levels nicotinamide phosphoribosyltransferase (NAMPT), rate-limiting enzyme NAD salvage pathway, which acts as negative regulator CXCR4 retention axis hematopoietic cells bone marrow. NAMPT inhibits through a NAD/Sirtuin 1–mediated inactivation HIF1α-driven gene transcription, leading mobilization immature...
Tumor-associated macrophages (TAM) are regulators of extracellular matrix (ECM) remodeling and metastatic progression, the main cause cancer-associated death. We found that disabled homolog 2 mitogen-responsive phosphoprotein (DAB2) is highly expressed in tumor-infiltrating TAMs its genetic ablation significantly impairs lung metastasis formation. DAB2-expressing TAMs, mainly localized along tumor-invasive front, participate integrin recycling, ECM remodeling, directional migration a...
Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest tumors owing to its robust desmoplasia, low immunogenicity, and recruitment cancer-conditioned, immunoregulatory myeloid cells. These features strongly limit success immunotherapy as a single agent, thereby suggesting need for development multitargeted approach. The goal foster T lymphocyte infiltration within tumor landscape neutralize cancer-triggered immune suppression, enhance therapeutic effectiveness...
Immunosuppression is a hallmark of tumor progression, and treatments that inhibit or deplete monocytic myeloid-derived suppressive cells could promote anti-tumor immunity. c-FLIP central regulator caspase-8-mediated apoptosis necroptosis. Here we show low-dose cytotoxic chemotherapy agents cause linked to down-regulation selectively in monocytes. Enforced expression viral FLIP rescues monocytes from cytotoxicity concurrently induces potent immunosuppressive activity, T cell cultures vivo...
Given the increasing consumer focus on healthier and environmentally friendly foods, use of natural antioxidants in food production is becoming more common. The recovery these from agri-food waste crucial for a circular economy, as it revalues matrices that would otherwise become waste. This study aimed to assess antioxidant capacity hazelnut skin its green polyphenolic extract evaluate their effect some qualitative parameters pork burgers. Three types burgers were formulated: control group,...
Telomerase (TERT) is a ribonucleoprotein enzyme that preserves the molecular organization at ends of eukaryotic chromosomes. Since TERT deregulation common step in leukaemia, treatments targeting telomerase might be useful for therapy hematologic malignancies. Despite large spectrum potential drugs, their bench-to-bedside translation quite limited, with only therapeutic vaccine clinic and inhibitor late stage preclinical validation. We recently demonstrated adoptive transfer T cell...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of ongoing pandemic disease 2019 (COVID-19). The majority patients with COVID-19 have a good prognosis, but variable percentages in different countries develop pneumonia associated lymphocytopenia and severe inflammatory response due to uncontrolled release cytokines. These immune mediators are transcriptionally regulated by JAK-STAT molecular pathways, which can be disabled small molecules. Here, we...
Abstract Coronavirus disease 2019 (COVID-19) may result in a life-threatening condition due to hyperactive immune reaction severe acute respiratory syndrome-coronavirus-2 infection, for which no effective treatment is available. Based on the potent immunomodulatory properties of mesenchymal stromal cells (MSCs), growing number trials are ongoing. This prompted us carry out thorough immunological study patient treated with umbilical cord-derived MSCs and admitted Intensive Care Unit...
Maternal immunization is successfully applied against some life-threatening infectious diseases as it can protect the mother and her offspring through passive transfer of maternal antibodies. Here, we sought to evaluate whether concept could also be cancer immune-prevention. We have previously shown that antibodies induced by DNA vaccination rat Her2 (neu) heterozygous neu-transgenic female (BALB-neuT) mice from autochthonous mammary tumor development. We, herein, seek a similar confer...
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related mortality among adults in developed countries. The discovery most common genetic alterations as well development organoid models pancreatic cancer have provided insight into fundamental pathways driving tumor progression from a normal cell to non-invasive precursor lesion and finally widely metastatic disease, offering new opportunities for identifying key driver evolution. Obesity one serious public health...
Abstract Since the beginning of SARS-CoV-2 pandemic, COVID-19 has appeared as a unique disease with unconventional tissue and systemic immune features. While severe forms share clinical laboratory aspects various pathologies such hemophagocytic lymphohistiocyto-sis, sepsis or cytokine release syndrome, their exact nature remains unknown. This is severely imped-ing ability to treat patients facing stages disease. To this aim, we performed an in-depth, single-cell RNA-seq analysis more than...
Abstract Since the beginning of SARS-CoV-2 pandemic, COVID-19 has appeared as a unique disease with unconventional tissue and systemic immune features. While severe forms share clinical laboratory aspects various pathologies such hemophagocytic lymphohistiocytosis, sepsis or cytokine release syndrome, their exact nature remains unknown. This is severely impeding ability to treat patients facing stages disease. To this aim, we performed an in-depth, single-cell RNA-seq analysis more than...