A5011074356- Mosquito-borne diseases and control
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Zoonotic diseases and public health
- Malaria Research and Control
- COVID-19 and Mental Health
- Influenza Virus Research Studies
- Viral Infections and Outbreaks Research
- Long-Term Effects of COVID-19
- Data-Driven Disease Surveillance
- Vector-borne infectious diseases
- SARS-CoV-2 and COVID-19 Research
- Health Literacy and Information Accessibility
- Mobile Health and mHealth Applications
- Social Media in Health Education
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Insect symbiosis and bacterial influences
- Animal Disease Management and Epidemiology
- Studies on Chitinases and Chitosanases
- Tuberculosis Research and Epidemiology
- Trypanosoma species research and implications
- Clostridium difficile and Clostridium perfringens research
- COVID-19 Impact on Reproduction
- HIV Research and Treatment
Université Libre de Bruxelles
2022-2025
University of Groningen
2017-2024
University Medical Center Groningen
2017-2024
University of Carabobo
2018-2019
Central University of Venezuela
2019
Haga Hospital
2017
Lack of specific definitions clinical characteristics, disease severity, and risk preventive factors post-COVID-19 syndrome (PCS) severely impacts research discovery new therapeutics drugs.This prospective multicenter cohort study was conducted from February 2020 to June 2022 in 5 countries, enrolling SARS-CoV-2 out- in-patients followed at 3-, 6-, 12-month diagnosis, with assessment biochemical features, antibody (Ab) response, Variant Concern (VoC), physical mental quality life (QoL)....
Abstract Dengue is a mosquito-borne viral disease of global impact. In Venezuela, dengue has emerged as one the most important public health problems urban areas with frequent epidemics since 2001. The long-term pattern this involved not only general upward trend in cases but also dramatic increase size and frequency epidemic outbreaks. By assuming that climate variability relevant influence on these changes time, we quantified periodicity incidence time-series data from two northern regions...
Malaria elimination in Latin America is becoming an elusive goal. cases reached a historical ~1 million 2017 and 2018, with Venezuela contributing 53% 51% of those cases, respectively. Historically, malaria incidence southern has accounted for most the country's total number cases. The efficient deployment disease prevention measures prediction spread to new regions requires in-depth understanding spatial heterogeneity on transmission dynamics. Herein, we characterized epidemiology from 2007...
Dengue virus (DENV) transmission is spatially heterogeneous. Hence, to stratify dengue prevalence in space may be an efficacious strategy target surveillance and control efforts a cost-effective manner particularly Venezuela where hyperendemic public health resources are scarce. Here, we determine hot spots of seroprevalence the risk factors associated with these clusters using local spatial statistics regression modeling approach.From August 2010 January 2011, community-based...
Summary Background The first case of COVID-19 was detected in Brazil on February 25, 2020. We report the epidemiological, demographic, and clinical findings for confirmed cases during month epidemic Brazil. Methods Individual-level aggregated data were analysed to investigate demographic profiles, socioeconomic drivers age-sex structure tested cases. Basic reproduction numbers ( R 0 ) investigated São Paulo Rio de Janeiro. Multivariate logistic regression analyses used identify symptoms...
Avian influenza (AI) is a highly contagious viral disease affecting poultry and wild water birds, posing significant global challenges due to its high mortality rates economic impacts. Highly pathogenic avian (HPAI) outbreaks, particularly those caused by H5N1 variants, have surged since their first occurrence in 1959. The HPAI clade 2.3.4.4b viruses notably expanded geographical reach, numerous countries, diverse species, now domestic mammals. Using an ecological niche modelling approach,...
Avian influenza (AI) is a highly contagious viral disease affecting poultry and wild water birds, posing significant global challenges due to its high mortality rates economic impacts. Highly pathogenic avian (HPAI) outbreaks, particularly those caused by H5N1 variants, have surged since their first occurrence in 1959. The HPAI clade 2.3.4.4b viruses notably expanded geographical reach, numerous countries, diverse species, now domestic mammals. Using an ecological niche modelling approach,...
Environmental factors, such as fluctuations of climatic conditions and land cover, play a pivotal role in driving infectious disease epidemics, particularly those originating from wildlife reservoirs. Orthohantavirus puumalaense, hosted by bank voles Europe, is the causative agent form haemorrhagic fever renal syndrome called nephropathia epidemica. Despite two decades consistent presence western epidemica outbreaks still pose challenges due to localised periodic occurrences lack...
Dengue, a viral mosquito-borne disease currently affects more than 2.5 billion people living in endemic areas worldwide. In vector control, social mobilization and community behavioral changes are of crucial importance. Here, we identified the factors influencing dengue preventive practices high-transmission urban area Venezuela. Between September 2013 February 2014, cross-sectional study at household level was carried out Maracay city, A precoded questionnaire used to obtain information on...
Testing and isolation have been crucial for controlling the COVID-19 pandemic. Venezuela has one of weakest testing infrastructures in Latin America low number reported cases country attributed to substantial underreporting. However, Venezuelan epidemic seems lagged behind other countries region, with most occurring within capital region four border states. Here, we describe spatial epidemiology its relation population mobility, migration patterns, non-pharmaceutical interventions fuel...
Dengue viruses are a significant global health concern, causing millions of infections annually and putting approximately half the world's population at risk, as reported by World Health Organization (WHO). Understanding spatial temporal patterns dengue virus spread is crucial for effective prevention future outbreaks. By investigating these patterns, targeted surveillance control measures can be improved, aiding in management outbreaks dengue-affected regions. Curaçao, where endemic, has...
Several studies reported alterations of the human gut microbiota (GM) during COVID-19. To evaluate potential role GM as an early predictor COVID-19 at disease onset, we analyzed microbial samples 315 patients that differed in severity. We observed significant variations diversity and composition associated with increasing severity, reduction short-chain fatty acid producers such
Background West Nile virus (WNV) has an enzootic cycle between birds and mosquitoes, humans being incidental dead-end hosts. Circulation of WNV is increasing public health threat in Europe. While detection notifiable animals the European Union, surveillance based on human case numbers presents some limitations, including reporting delays. Aim We aimed to perform risk mapping circulation leading infections Europe by integrating two types systems: indicator-based event-based surveillance....
The coronavirus disease 2019 (COVID-19) pandemic has particularly affected countries with weakened health services in Latin America, where proper patient management could be a critical step to address the epidemic. In this study, we aimed characterize and identify which epidemiological, clinical, paraclinical risk factors defined COVID-19 infection from first confirmed cases through epidemic wave Venezuela. A retrospective analysis of consecutive suspected admitted sentinel hospital was...
We developed an IgM-based ELISA that identifies the dengue virus serotype of recent infections. Dominant serotypes were detectable in 91.1% samples from travelers and 86.5% residents endemic regions; 97.1% corresponded to identified by PCR. This enables more accurate reporting epidemiologic findings.
Since chikungunya virus emerged in the Caribbean region late 2013, ≈45 countries have experienced outbreaks. We described and quantified spatial temporal events after introduction propagation of into an immunologically naive population from urban north-central Venezuela during 2014. The epidemic curve (n = 810 cases) unraveled within 5 months with a basic reproductive number 3.7 radial spread traveled distance 9.4 km at mean velocity 82.9 m/day. highest disease diffusion speed occurred first...
Digitally delivering healthcare services is very attractive for tuberculosis (TB) management as this disease has a complex diagnosis and lengthy involves multiple medical nonmedical specialists. Especially in low- middle-income countries, eHealth could potentially offer cost-effective solutions to bridge financial, social, time, distance challenges.The goal of the research understand what would make globally applicable gain insight into different TB situations, opportunities, challenges.We...
Guidelines on COVID-19 management are developed as we learn from this pandemic. However, most research has been done hospitalised patients and the impact of disease non-hospitalised their role in transmission not yet well understood. The COVID HOME study conducts among family members who were during acute disease, to guide patient care inform public health guidelines for infection prevention control community household. An ongoing prospective longitudinal observational outpatients was...
Dengue virus (DENV), an arthropod-borne virus, has rapidly spread in recent years. DENV diagnosis is performed through serology, isolation or molecular detection, while genotyping usually done Sanger sequencing of the envelope gene. This study aimed to optimize use shotgun metagenomics and subsequent bioinformatics analysis detect type directly from clinical samples without targeted amplification. Additionally, presence quasispecies (intra-host variation) was revealed by detecting single...
Dengue is a disease endemic in Latin American countries, like Venezuela, and has become one of the most important public health problems. We report five complete coding sequences dengue virus serotype 2 (DENV-2) isolated from DENV-infected patients Venezuela. Phylogenetic analysis placed isolates within American/Asian genotype.
Avian influenza (AI) is a highly contagious viral disease affecting poultry and wild water birds, posing significant global challenges due to its high mortality rates economic impacts. Highly pathogenic avian (HPAI) outbreaks, particularly those caused by H5N1 variants, have surged since their first occurrence in 1959. The HPAI clade 2.3.4.4b viruses notably expanded geographical reach, numerous countries, diverse species, now domestic mammals. Using an ecological niche modelling approach,...