A5076424795- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Insect symbiosis and bacterial influences
- Malaria Research and Control
- Invertebrate Immune Response Mechanisms
- Parasites and Host Interactions
- Parasitic Diseases Research and Treatment
- Viral Infections and Outbreaks Research
- Virology and Viral Diseases
- Insect Resistance and Genetics
- Insect Pest Control Strategies
- COVID-19 epidemiological studies
- Insect Utilization and Effects
- Zoonotic diseases and public health
- HIV Research and Treatment
- Studies on Chitinases and Chitosanases
- Vector-Borne Animal Diseases
- Trypanosoma species research and implications
- Vector-borne infectious diseases
- Travel-related health issues
- Cytomegalovirus and herpesvirus research
- COVID-19 Pandemic Impacts
- Venomous Animal Envenomation and Studies
- Respiratory viral infections research
- Animal Disease Management and Epidemiology
Texas A&M University
2022-2025
Colorado State University
2017-2025
Universidade Federal da Bahia
2022-2024
Fundação Oswaldo Cruz
2007-2021
University of Miami
2008
Texas Biomedical Research Institute
2007
Tulane University
2002
Ezequiel Dias Foundation
2001
A low-cost, equipment-free rapid antigen test distinguishes dengue virus serotypes and Zika in patient sera without detectable cross-reactivity.
Ivermectin is widely used in mass drug administrations for controlling neglected parasitic diseases, and can be lethal to malaria vectors that bite treated humans. Therefore, it could a new tool reduce plasmodium transmission. We tested the hypothesis frequently repeated of ivermectin village residents would clinical episodes children well tolerated with minimal harms.We invited villages (clusters) Burkina Faso participate single-blind (outcomes assessor), parallel-assignment, two-arm,...
A rapid, specific, sensitive, and inexpensive method has been developed that detects RNA from a Zika virus strain associated with the current outbreak.
The burden of dengue continues to increase globally, with an estimated 100 million clinically apparent infections occurring each year. Although most are asymptomatic, patients can present a wide spectrum clinical symptoms ranging from mild febrile illness through severe manifestations bleeding, organ impairment, and hypovolaemic shock due systemic vascular leak syndrome. Clinical diagnosis identification which likely develop disease remain challenging. This study aims improve management...
Background The mosquito Aedes aegypti is one of the most important disease vectors because it transmits two major arboviruses, dengue and yellow fever, which cause significant global morbidity mortality. Chemical insecticides form cornerstone vector control. organophosphate temephos a larvicide recommended by WHO for controlling Ae. aegypti, however, resistance to this compound has been reported in many countries, including Brazil. Methodology/Principal Findings aim study was identify genes...
Background Several arboviruses, including dengue virus (DENV), Zika (ZIKV) and chikungunya (CHIKV), transmitted by Aedes mosquitoes, circulate in northeast Brazil. Diseases caused these viruses are of great public health relevance, however, their epidemiological features areas where the three co-circulate scarce. Here, we present analyses molecular serological diagnostics a prospective study acute febrile patients recruited from May 2015 to 2016 Recife, Methods Two hundred sixty-three with...
B-cell epitope sequences from Zika virus (ZIKV) NS1 protein have been identified using prediction tools. Mapping these onto the surface reveals two major conformational epitopes and a single linear one. Despite an overall average sequence identity of ca. 55% between ZIKV four dengue (DENV) serotypes, were found to be highly conserved. Nevertheless, nonconserved epitope-flanking residues are responsible for dramatically divergent electrostatic potential on regions DENV2 serotypes. These...
In urban settings, chikungunya, Zika, and dengue viruses are transmitted by Aedes aegypti mosquitoes. Since these co-circulate in several regions, coinfection humans vectors may occur, human coinfections have been frequently reported. Yet, little is known about the molecular aspects of virus interactions within hosts how they contribute to arbovirus transmission dynamics. We previously shown that exposed chikungunya Zika same blood meal can become coinfected transmit both simultaneously....
In this Editorial, we list and discuss some of the main challenges faced by population public health authorities in Brazil concerning arbovirus infections, including occurrence concurrent epidemics like ongoing SARS-CoV-2/COVID-19 pandemic.
Antigenic similarities between Zika virus (ZIKV) and other flaviviruses pose challenges to the development of virus-specific diagnostic tools effective vaccines. Starting with a DNA-encoded one-bead-one-compound combinatorial library 508,032 synthetic, non-natural oligomers, we selected characterized small molecules that mimic ZIKV epitopes. High-throughput fluorescence-activated cell sorter-based bead screening was used select bound IgG from ZIKV-immune but not dengue-immune sera. Deep...
The use of Wolbachia as a tool to control insect vectors has recently been suggested. In this context, studies on the prevalence and diversity bacterium in wild populations are relevant. Here, we evaluated two Wolbachiagenes (ftsZ wsp) endosymbiont Aedes albopictus. Using semi-nested polymerase chain reaction, our results showed that 99.3% individuals were superinfected with Wolbachia. regards genetic diversity, genes no variation within or among mosquito populations. An analysis other...
Abstract Catalase is a potent antioxidant, likely involved in post‐blood meal homeostasis mosquitoes. This enzyme breaks down H 2 O , preventing the formation of hydroxyl radical (HO · ). Quiescins are newly classified sulfhydryl oxidases that bear thioredoxin motif at N‐terminal and an ERV1‐like portion C‐terminal. These proteins have major role generating disulfides intra‐ or extracellular environments, thus participate redox reactions. In search for molecules to serve as targets novel...
The innate immune response of insects is one the factors that may dictate their susceptibility to viral infection. Two signaling pathways, Toll and JAK-STAT, RNA interference (RNAi) pathway are involved in Aedes aegypti responses against dengue virus (DENV), however natural differences these antiviral defenses among mosquito populations have not been studied. Here, two field Ae. from distinct ecological environments, Recife other Petrolina (Brazil), a laboratory strain were studied for...
Infectious disease (ID) cohorts are key to advancing public health surveillance, policies, and pandemic responses. Unfortunately, ID often lack funding store share clinical-epidemiological (CE) data high-dimensional laboratory (HDL) long term, which is evident when the link between these elements not kept up date. This becomes particularly apparent smaller fail successfully address initial scientific objectives due limited case numbers, also limits potential pool studies monitor long-term...
The gains made against malaria have stagnated since 2015, threatened further by increasing resistance to insecticides and antimalarials. Improvement in control necessitates a multipronged strategy, which includes the development of novel tools. One such tool is mass drug administration (MDA) with endectocides, primarily ivermectin, has shown promise reducing transmission through lethal sublethal impacts on mosquito vector.