A5060343179- Fibromyalgia and Chronic Fatigue Syndrome Research
- Long-Term Effects of COVID-19
- Musculoskeletal pain and rehabilitation
- Genetic Neurodegenerative Diseases
- Health, psychology, and well-being
- COVID-19 and Mental Health
- Global Maternal and Child Health
- Multiple Sclerosis Research Studies
- Autoimmune and Inflammatory Disorders Research
- Child Nutrition and Water Access
- Muscle Physiology and Disorders
- Workplace Health and Well-being
- Resilience and Mental Health
- Folate and B Vitamins Research
- Olfactory and Sensory Function Studies
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Global Health and Surgery
- Gestational Diabetes Research and Management
- Diet, Metabolism, and Disease
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obesity, Physical Activity, Diet
- Respiratory viral infections research
- Nutrition and Health in Aging
- Phytoestrogen effects and research
London School of Hygiene & Tropical Medicine
2014-2025
B.C. Women's Hospital & Health Centre
2019-2024
University of British Columbia
2021-2024
Women's Health Research Institute
2022-2024
Provincial Health Services Authority
2024
Diakonissenkrankenhaus
2023
University of London
2005-2022
Universidade de São Paulo
2020
Universidad de Londres
2020
PHG Foundation
2010-2015
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) or chronic (CFS) has been used to name a range of conditions characterized by extreme and other disabling symptoms. Attempts estimate the burden disease have limited selection bias, lack diagnostic biomarkers agreed reproducible case definitions. We estimated prevalence incidence ME/CFS in three regions England, discussed implications frequency statistics use different definitions for health social care planning research. compared...
Designed by a group of ME/CFS researchers and health professionals, the European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE) has received funding from Cooperation in Science Technology (COST)-COST action 15111-from 2016 to 2020. The main goal Cost Action was assess existing knowledge experience care delivery for people with (ME/CFS) countries, enhance coordinated research provision this field. We report our findings make recommendations clinical diagnosis,...
We propose a framework for understanding and interpreting the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) that considers wider determinants health long-term temporal variation in pathophysiological features disease phenotype throughout natural history disease. As other chronic diseases, ME/CFS evolves through different stages, from asymptomatic predisposition, progressing to prodromal stage, then symptomatic Disease incidence depends on genetic makeup...
Diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome or ME/CFS is largely based on clinical history, and exclusion identifiable causes chronic fatigue. Characterization cases the impact interventions have been limited due to heterogeneity a lack reliable biomarkers for diagnosis outcome measures. People with (PWME) often report high levels disability, which are difficult measure objectively. The well being family members those who care PWME also likely be affected. This study...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition with unknown aetiology, unclear pathophysiology and no diagnostic test or biomarker available. Many patients report their ME/CFS began after an acute infection, subsequent increased frequency of infections, such as colds influenza, common. These factors imply altered immunological status exists in ME/CFS, at least proportion patients, yet previous studies peripheral immunity have been discrepant...
Introduction A significant proportion of individuals suffering from post COVID-19 condition (PCC, also known as long COVID) can present with persistent, disabling fatigue similar to myalgic encephalomyelitis/chronic syndrome (ME/CFS) and post-viral syndromes. There remains no clear pharmacological therapy for patients this subtype PCC, which be referred post-COVID (PCFS). low dose the opioid antagonist naltrexone (ie, low-dose (LDN)) has emerged an off-label treatment treating other symptoms...
Estudo transversal de base populacional na Cidade Pelotas, Sul do Brasil, entre 1999 e 2000, para descrever a distribuição adiposidade abdominal população acordo com os níveis intervenção identificar fatores risco. O estudo incluiu uma amostra 1.935 adultos (20-69 anos) residentes zona urbana município. Obesidade foi classificada como nível I circunferência da cintura (CCnI) 80-88cm em mulheres 94-102cm homens; II (CCnII) > 88cm 102cm homens. Apresentavam obesidade 62% das 37% dos Os...
To evaluate the role of central adiposity, as evaluated by measurement waist circumference (WC), an independent risk factor for hypertension and type 2 diabetes mellitus in setting a developing country.Population-based, cross-sectional study.A medium-sized town southern Brazil.One thousand ninety-five non-pregnant women, 20 to 69 years old, recruited cluster random sampling between 1999 2000. Their mean WC was 85.3 cm (standard deviation 13.9 cm) 23.3% (n=255) were obese (body mass index >30...
People with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) continue to struggle have their condition recognised as disabling in the face of public and professional prejudice discrimination. The aim this study was compare functional status well-being people well-characterised ME/CFS multiple sclerosis (PWMS), well healthy controls (HCs). In cross-sectional study, we used data collected part UK Biobank actual participant scores from Medical Outcomes Survey Short Form-36 v2™...
Background: The diagnosis of myalgic encephalomyelitis (ME/CFS) in research and clinical practice has largely relied on history, which can be subjective nature. Clinical signs are often subtle, overlap with other conditions, not formally included as part diagnostic workup. characterization biomarkers is needed for better classification patients to monitor treatment response. Hand grip strength (HGS) been used an objective measure muscle fatigue, a primary symptom ME/CFS. We assessed the...
Fatigue is a common symptom in hospitalized and non-hospitalized patients recovering from COVID-19, but no fatigue measurement scales or questions have been validated these populations. The objective of this study was to perform validity assessments the severity scale (FSS) two single-item screening (SISQs) for COVID-19.We examined ≥ 28 days after their first SARS-CoV-2 infection who were acute illness, as well referred persistent symptoms. Patients completed questionnaires through 1 4 Post...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating but poorly-understood disease. ME/CFS symptoms can range from mild to severe, and include immune system effects alongside incapacitating post-exertional disease exacerbation. In this study, we examined immunological profiles of people living with by flow cytometry, focusing on cytotoxic cells, determine whether mild/moderate (n= 43) or severe (n=53) expressed different markers. We found that had increased...
Primary care data show that 765 000 people in England have a general practice (GP) diagnosis of chronic obstructive pulmonary disease (COPD). We hypothesized this underestimates actual prevalence, and compared expected prevalence COPD for English local authority areas with diagnosed COPD. Cross-sectional comparison GP observed model-based estimates (using spirometry without clinical diagnosis) from the Health Survey England. Local underdiagnosis was estimated as ratio to cases. investigated...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling disease characterized by unexplained incapacitating fatigue, accompanied variable multi-systemic symptoms. ME/CFS causes significant personal and public health burden, urgently requires the coordination of research efforts to investigate its etiology pathophysiology develop validate sensitive specific biomarkers confirm diagnosis. This narrative paper describes how people with ME/CFS, together multidisciplinary team...
Autoimmunity and chronic viral infections are recurrent clinical observations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a complex disease with an unknown cause. Given these observations, the regulatory CD4+ T cells (Tregs) show promise to be good candidates for underlying pathology due their known capacity suppress immune responses not only body components but also against infections. Here we discussed overlooked role of chronicity Human Herpes Virus 6 (HHV6), Simplex 1...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease presenting with extreme fatigue, post-exertional malaise, and other symptoms. In the absence of diagnostic biomarker, ME/CFS diagnosed clinically, although laboratory tests are routinely used to exclude alternative diagnoses. this analytical cross-sectional study, we aimed explore potential haematological biochemical markers for ME/CFS, severity. We reviewed test results from 272 people 136 healthy controls...
Abstract Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex disease, whose exact cause remains unclear. A wide range of risk factors has been proposed that helps understanding potential disease pathogenesis. However, there little consistency for many factor associations, thus we undertook an exploratory study using data from the UK ME/CFS Biobank participants. We report on associations in compared with multiple sclerosis participants and healthy controls....
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex chronic condition affecting multiple body systems, with unknown cause, unclear pathogenesis mechanisms, and fluctuating symptoms which may lead to severe debilitation. It frequently reported have been triggered by an infection, but there are no clear differences in exposure to, or seroprevalence of, any particular viruses between people ME/CFS healthy individuals. However, herpes repeatedly hypothesized underlie the...