A5052568487- Listeria monocytogenes in Food Safety
- Salmonella and Campylobacter epidemiology
- Essential Oils and Antimicrobial Activity
- Microbial Inactivation Methods
- Effects and risks of endocrine disrupting chemicals
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Pesticide Exposure and Toxicity
- COVID-19 Impact on Reproduction
- Toxic Organic Pollutants Impact
- Animal testing and alternatives
- Enterobacteriaceae and Cronobacter Research
- Viral gastroenteritis research and epidemiology
- Food Safety and Hygiene
- Contact Dermatitis and Allergies
- Streptococcal Infections and Treatments
- Pregnancy and preeclampsia studies
- Asthma and respiratory diseases
- Mycotoxins in Agriculture and Food
- Per- and polyfluoroalkyl substances research
- Plant Pathogens and Fungal Diseases
- Plant-Microbe Interactions and Immunity
- Insect and Pesticide Research
- Trace Elements in Health
- Pregnancy and Medication Impact
University of Georgia
2009-2024
Charles River Laboratories (United States)
2024
Environmental Protection Agency
2024
Mississippi State University
2024
National Center for Toxicological Research
1988-2024
Food and Drug Administration
2024
Center for Food Safety and Applied Nutrition
2024
Howard University
2024
University of Milan
2024
United States Food and Drug Administration
2024
Leukotriene B4 (LTB4) is a product of the 5-lipoxygenase pathway arachidonic acid metabolism. LTB4 potent chemotactic factor for neutrophils and has been postulated to play an important role in variety pathological conditions including rheumatoid arthritis (RA), psoriasis, inflammatory bowel disease. The such diseases not yet defined but this paper we provide direct evidence that plays critical murine model RA. CP-105,696, (+)-1-(3S,4R)-[3-(4-phenylbenzyl)- 4-hydroxychroman-7-yl]cyclopentane...
ABSTRACT Epidemiological studies have shown a potential association between maternal periodontitis and pregnancy complications. We used pregnant murine model to study the effect of infection with periodontal pathogen Porphyromonas gingivalis on outcomes. Female BALB/c mice were inoculated heat-killed P. (10 9 CFU) in subcutaneous chamber mated 2 weeks later. At gestation day (GD) 7.5, challenged live 7 ( n = 20) or broth (control; 8) sacrificed at GD 16.5. Fetal growth restriction (FGR,...
ABSTRACT Our previous animal studies showed that maternal Porphyromonas gingivalis infection in a subcutaneous chamber is associated with hepatic and uterine translocation, as well systemic induction of inflammatory responses, both which were fetal growth restriction (FGR). However, P. gingivalis- challenged dams had fetuses either FGR (2 standard deviations below mean weight nonchallenged dams) or normal weight. Therefore, the objective this study was to determine whether compromises...
Food-related illness in the United States is estimated to affect over six million people per year and cost economy several billion dollars. These illnesses costs could be reduced if minimum infectious doses were established used as basis of regulations monitoring. However, standard methodologies for dose-response assessment are not yet formulated microbial risk assessment. The objective this study was compare models food-borne pathogens determine which most appropriate a range pathogens....
The fungus Fusarium verticillioides infects maize and produces fumonisins, inhibitors of ceramide synthase. Seeds the cultivar Silver Queen were inoculated with fumonisin-producing or non-fumonisin-producing strains F. verticillioides. Leaf lesion incidence severity effects on root stalk growth significantly correlated fumonisin in roots disruption sphingolipid metabolism roots. Uninoculated seeds grown soil watered solutions B1 exhibited above-ground symptoms indicative...
Listeria monocytogenes, isolated from outbreaks in either human or nonhuman primate populations, was administered orally at doses ranging 10(6) to 10(10) CFU. Four of 10 treated animals delivered stillborn infants. L. monocytogenes fetal tissue, and the pathology consistent with infection as cause pregnancy loss. For all pregnancies resulting stillbirths, maternal feces, indicating that had survived probably colonized gastrointestinal tract. Antibodies antigen-specific lymphocyte...
ABSTRACT A dose-response model using rhesus monkeys as a surrogate for pregnant women indicates that oral exposure to 10 7 CFU of Listeria monocytogenes results in about 50% stillbirths. Ten 33 exposed orally single dose 2 L . had log-logistic predicts affecting animals at CFU, comparable an estimated 6 based on outbreak among but much less than the extrapolated estimate (10 13 CFU) from FDA-U.S. Department Agriculture-CDC risk assessment exponential curve mouse data. Exposure and etiology...
8-2 Fluorotelomer alcohol (FTOH) and its metabolites, perfluorooctanoic acid (PFOA) perfluorononanoic (PFNA), are developmental toxicants but metabolism distribution during pregnancy not known. To examine this, timed-pregnant mice received a single gavage dose (30 mg FTOH/kg body weight) on gestational day (GD) 8. Maternal neonatal serum liver as well fetal homogenate extracts were analyzed using gas chromatography coupled with mass spectrometry. During gestation (GD9 to GD18), maternal...
The behaviour of six species African schistosomes and their hybrids has been compared qualitatively quantitatively in baboons, with a view to finding schistosome high infectivity but low pathogenicity the baboon for use heterologous immunity experiments. This study, which includes first comparative study these primates, is complementary earlier studies rodents were terms egg morphology, snail infectivity, pathogenicity. In rodents, statistically significant differences detected each pair...
The use of antibiotic growth promotants in poultry rearing is a public health concern due to resistance bacteria and the harborage genes. Lupulone, hop β-acid from Humulus lupulus, has been considered as potential feed additive promotant. Here, effect lupulone was evaluated for its on microbiota chicken intestine. intestinal broilers quantified after addition 125 mg L−1 water challenge with Clostridium perfringens. Microbial DNA extracted broiler midgut cecal sections bacterial groups were...
Food‐related illness in the United States is estimated to affect over six million people per year and cost economy several billion dollars. These illnesses costs could be reduced if minimum infectious doses were established used as basis of regulations monitoring. However, standard methodologies for dose‐response assessment are not yet formulated microbial risk assessment. The objective this study was compare dose response models food‐borne pathogens determine which most appropriate a range...
Background: Recent studies have suggested that subclinical infection may be an important cause of low birth weight. Campylobacters are human pathogens, causing septicemia and occasionally abortion, premature labor, or severe perinatal infection. The potential role oral species Campylobacter in mediating adverse pregnancy outcomes animal models has not yet been determined. Our objective was to determine the effects rectus ( C. ) on a mouse model. Methods: On embryonic day (E) 7.5, pregnant...
During the past century, microbiological safety of US food supply has improved; however, many foodborne illnesses and outbreaks occur annually. Hence, opportunities for industry to improve both domestic imported exist through adoption risk-based preventive measures. Challenging issues that are on horizon include demographic changes a population whose immune system is more susceptible opportunistic pathogens, climate will shift where produced, consumers' preferences raw minimally processed...
CP-195543 [(+)-2-(3-benzyl-4-hydroxy-chroman-7-yl)-4-trifluoromethyl-benzoic acid] is a structurally novel, selective and potent leukotriene B4 (LTB4) receptor antagonist. In vitro inhibited [3H]LTB4 binding to high-affinity LTB4 receptors on human neutrophils (HN) murine spleen membranes with IC50 values of 6.8 nM (Ki = 4.9 nM) 37.0 26.9 nM), respectively. mouse neutrophil chemotaxis mediated by 2.4 7.5 nM, Evidence noncompetitive antagonist effects the HN was obtained Scatchard analysis...