Carmen Adella Sîrbu
A5054312365- Multiple Sclerosis Research Studies
- Systemic Sclerosis and Related Diseases
- Polyomavirus and related diseases
- Rheumatoid Arthritis Research and Therapies
- Peripheral Neuropathies and Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Lupus Erythematosus Research
- Cerebral Venous Sinus Thrombosis
- Glioma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Diet and metabolism studies
- Long-Term Effects of COVID-19
- Epilepsy research and treatment
- COVID-19 Clinical Research Studies
- Metabolism and Genetic Disorders
- Toxin Mechanisms and Immunotoxins
- Gene expression and cancer classification
- Neurological disorders and treatments
- Immunotherapy and Immune Responses
- Migraine and Headache Studies
- Bioinformatics and Genomic Networks
- Neuroblastoma Research and Treatments
- Brain Metastases and Treatment
- Nutritional Studies and Diet
- Mycobacterium research and diagnosis
Academy of Romanian Scientists
2023-2025
Carol Davila University of Medicine and Pharmacy
2014-2025
Titu Maiorescu University
2016-2024
"Dunarea de Jos" University of Galati
2024
Emergency University
2014-2024
The University of Queensland
2023
QIMR Berghofer Medical Research Institute
2023
University of Tasmania
2023
The University of Melbourne
2014-2023
Barwon Health
2023
Designed by a group of ME/CFS researchers and health professionals, the European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE) has received funding from Cooperation in Science Technology (COST)-COST action 15111-from 2016 to 2020. The main goal Cost Action was assess existing knowledge experience care delivery for people with (ME/CFS) countries, enhance coordinated research provision this field. We report our findings make recommendations clinical diagnosis,...
The aim of this work was to evaluate sex differences in the incidence multiple sclerosis relapses; assess relationship between and primary progressive disease course; compare effects age duration on relapse incidence. Annualized rates were calculated using MSBase registry. Patients with incomplete data or <1 year follow-up excluded. only included ratio analysis. Relapse incidences over 40 years 70 compared females males Andersen-Gill Tweedie models. Female-to-male ratios stratified by annual...
Objectives: The aim was to analyse risk of relapse phenotype recurrence in multiple sclerosis and characterise the effect demographic clinical features on this phenotype. Methods: Information about relapses collected using MSBase, an international observational registry. Associations between phenotypes history similar or patient characteristics were tested with multivariable logistic regression models. Tendency recur sequentially assessed principal component analysis. Results: Among 14,969...
Background: Time matters in multiple sclerosis (MS). Irreversible neural damage and cell loss occur from disease onset. The MS community has endorsed a management strategy of prompt diagnosis, timely intervention regular proactive monitoring treatment effectiveness activity to improve outcomes people with MS. Objectives: We sought develop internationally applicable quality standards for timely, brain health–focused care. Methods: A panel specialist neurologists participated an iterative,...
Objective: Objective and reproducible evaluation of data quality is paramount importance for studies ‘real-world’ observational data. Here, we summarise a standardised quality, density generalisability process implemented by MSBase, global multiple sclerosis (MS) cohort study. Methods: Error rate, score were developed using all 35,869 patients enrolled in MSBase as November 2015. The was calculated across six domains (follow-up, demography, visits, MS relapses, paraclinical therapy)...
<h3>Objective</h3> To test the hypothesis that immunotherapy prevents long-term disability in relapsing-remitting multiple sclerosis (MS), we modeled outcomes 14,717 patients. <h3>Methods</h3> We studied patients from MSBase followed for ≥1 year, with ≥3 visits, visit per and exposed to MS therapy, a subset of ≥15-year follow-up. Marginal structural models were used compare cumulative hazards 12-month confirmed increase decrease disability, Expanded Disability Status Scale (EDSS) step 6,...
There has been a continued search for more sensitive noninvasive technique detecting sub-clinical acute rejection in heart transplant recipients. Ultrasonic deformation imaging (strain/strain rate) is abnormalities regional systolic function and could potentially be sufficiently to detect changes induced by graft rejection.To assess the use of strain (S) rate (SR) as method monitoring diagnosing recipients.A prospective preliminary study was carried out involving 31 consecutive patients who...
Objectives We conducted a prospective study, MSBASIS, to assess factors leading first treatment discontinuation in patients with clinically isolated syndrome (CIS) and early relapsing-remitting multiple sclerosis (RRMS). Methods The MSBASIS Study, by MSBase Study Group members, enrols seen from CIS onset, reporting baseline demographics, cerebral magnetic resonance imaging (MRI) features Expanded Disability Status Scale (EDSS) scores. Follow-up visits report relapses, EDSS scores, the start...
This study aims to identify cardiovascular risk factors among 91 patients with multiple sclerosis in Bucharest, Romania, using data from medical records and a self-administered questionnaire. The research focuses on smoking status, body mass index, blood sugar, cholesterol, triglycerides, pressure renal function. average age of the was 42.90 ± 10.60 years 74.73% were female. BMI 23.89 kg/m2 4.74 (lower than general population), 41.76% having outside normal limits. majority former smokers...
Background and Objectives: This study aims to identify cardiovascular risk factors among 91 patients with multiple sclerosis in Bucharest, Romania, using data from medical records a self-administered questionnaire. Materials Methods: The research focuses on smoking status, body mass index, blood sugar, cholesterol, triglycerides, pressure, renal function. average age of the was 42.90 ± 10.60 years, 74.73% were female. BMI 23.89 kg/m2 4.74 (lower than general population), 41.76% having...
<h3>Objective:</h3> To investigate the effect of disease-modifying treatment on short-term disability outcomes in secondary progressive multiple sclerosis (SPMS). <h3>Methods:</h3> Using MSBase, an international cohort study, we previously validated a highly accurate definition SPMS. Here, identified patients MSBase who were either untreated or treated with drug when meeting this definition. Propensity score matching was used to select subpopulations comparable baseline characteristics....
Abstract In multiple sclerosis, treatment start or switch is prompted by evidence of disease activity. Whilst immunomodulatory therapies reduce activity, the time required to attain maximal effect unclear. this study we aimed develop a method that allows identification manifest fully and clinically sclerosis treatments (‘therapeutic lag’) on clinical activity represented relapses progression-of-disability events. Data from two registries, MSBase (multinational) OFSEP (French), were used....
Background: The results of head-to-head comparisons injectable immunomodulators (interferon β, glatiramer acetate) have been inconclusive and a comprehensive analysis their effectiveness is needed. Objective: We aimed to compare, in real-world setting, relapse disability outcomes among patients with multiple sclerosis (MS) treated immunomodulators. Methods: Pairwise the international MSBase registry data was conducted using propensity-score matching. four were compared six analyses paired...
<h3>Abstract</h3> <h3>Background:</h3> We compared efficacy and treatment persistence in treatment-naive patients with relapsing-remitting multiple sclerosis (RRMS) initiating natalizumab interferon-β (IFN-β)/glatiramer acetate (GA) therapies, using propensity score–matched cohorts from observational registries. <h3>Methods:</h3> The study population initiated IFN-β/GA the MSBase Registry or Tysabri Observational Program, had ≥3 months of on-treatment follow-up, active RRMS, defined as ≥1...
ME/CFS is a chronic, complex, multisystem disease that often limits the health and functioning of affected patients. Diagnosing patients with challenge, many different case definitions exist are used in clinical practice research. Even after diagnosis, medical treatment very challenging. Symptom relief coping may affect how live their quality life. There no consensus on which diagnostic criteria should be strategies can recommended for The purpose current project was to map landscape...
Videocapillaroscopy is a simple, non-invasive investigation that allows the "in vivo" study of nailfold capillaries. This method inexpensive, easily accepted by patients and results can be interpreted. It mainly used in with Raynaud's phenomenon systemic sclerosis, but this examination also performed on who are suspected having microcirculation alterations, such as rheumatoid arthritis psoriatic arthritis. may aid diagnosis, evaluation prognosis other rheumatic diseases, besides sclerosis....
Background: Infective endocarditis (IE) is a pathological condition caused by various microbial agents that can lead to severe complications affecting the heart. Accurate diagnosis crucial for effective management of patients with IE. Blood culture gold standard identifying primary infectious agents, which key factor in diagnosing IE using modified Duke criteria. Objective: The main objective this study was investigate distribution etiological and most common secondary diagnoses associated...