A5020631714- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Global Maternal and Child Health
- Congenital Anomalies and Fetal Surgery
- Parasitic infections in humans and animals
- COVID-19 epidemiological studies
- Schizophrenia research and treatment
- Dengue and Mosquito Control Research
- Child and Adolescent Psychosocial and Emotional Development
- Amoebic Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Evolution and Genetic Dynamics
- Neuroscience and Neural Engineering
- Zoonotic diseases and public health
- Data Quality and Management
- Gastric Cancer Management and Outcomes
- Health and Medical Studies
- ECG Monitoring and Analysis
- Bacterial Infections and Vaccines
- Esophageal Cancer Research and Treatment
- Virology and Viral Diseases
- Maternal Mental Health During Pregnancy and Postpartum
University Hospital Cologne
2021-2025
University of Cologne
2021-2025
Heidelberg University
2010-2022
University Hospital Heidelberg
2010-2022
German Center for Infection Research
2021
Heidelberg University
2017
Humboldt State University
2016
Institute of Public Health
2010
Background Imaging plays the key role in diagnosing and staging of CE. The description CE-specific imaging features WHO CE cyst classification is based on ultrasound. reproducibility ultrasound-defined cysts variable MR- CT-imaging. This particular importance for that are not accessible by US because increasing availability overuse CT MR imaging. Methodology/Principal Findings Retrospective analysis patients with abdominal an interdisciplinary clinic who had and/or MRI scans performed...
To estimate the risk of microcephaly in babies born to women infected by Zika virus during pregnancy Brazil an epidemic between 2015 and 2016.We obtained data on number notified confirmed cases each Brazilian state November October 2016 from health ministry. For Pernambuco State, one hardest hit, weekly were available August for different definitions microcephaly. The absolute was calculated using average live births reported corresponding time period 2012 2014 assuming two infection rates:...
The burden of dengue continues to increase globally, with an estimated 100 million clinically apparent infections occurring each year. Although most are asymptomatic, patients can present a wide spectrum clinical symptoms ranging from mild febrile illness through severe manifestations bleeding, organ impairment, and hypovolaemic shock due systemic vascular leak syndrome. Clinical diagnosis identification which likely develop disease remain challenging. This study aims improve management...
Dengue infection can cause a wide spectrum of clinical outcomes. The severe manifestations occur sufficiently late in the disease course, during day 4-6 illness, to allow window opportunity for risk stratification. Markers inflammation may be useful biomarkers. We investigated value C-reactive protein (CRP) measured early on illness days 1-3 predict dengue outcome and difference CRP levels between other febrile illnesses (OFI).We performed nested case-control study using data samples...
Background Several arboviruses, including dengue virus (DENV), Zika (ZIKV) and chikungunya (CHIKV), transmitted by Aedes mosquitoes, circulate in northeast Brazil. Diseases caused these viruses are of great public health relevance, however, their epidemiological features areas where the three co-circulate scarce. Here, we present analyses molecular serological diagnostics a prospective study acute febrile patients recruited from May 2015 to 2016 Recife, Methods Two hundred sixty-three with...
Overdiagnosis and overtreatment are rarely discussed in the context of NTDs despite their relevance for patients under care health services with limited resources where risks therapy induced complications often disproportionate to benefit. The advantages cyst staging-based management cystic echinococcosis (CE) not yet fully explored. Questions are: Do inactive cysts (CE 4 CE 5) need treatment is there a difference between which reach CE4 CE5 naturally or by benzimidazole therapy?Analysis...
Current treatment methods do not achieve recovery for most individuals with schizophrenia, and symptoms such as negative cognitive deficits often persist. Aerobic endurance training has been suggested a potential add-on targeting both physical mental health. We performed large-scale multicenter, rater-blind, parallel-group randomized controlled clinical trial in stable schizophrenia. Participants underwent professionally supervised six-month comprising either aerobic (AET) or flexibility,...
Persistent poor psychosocial functioning, which is associated with impairments in cognition, one of the main barriers to recovery schizophrenia. Although cognitive remediation therapy (CRT) has shown general efficacy improving cognition and simultaneously focusing on social behavioural processes may increase its efficacy. In a multicenter, rater-blinded, randomized controlled trial, schizophrenia patients (N = 177) were assigned six months either Integrated Social Cognitive Behavioral Skills...
Empirical evidence supports the efficacy of behavioral online parent training. However, further large trials in school-age children with externalizing behavior problems and analyses on impact additional therapist support are needed. This three-arm randomized controlled trial examined guided unguided web-assisted self-help (WASH) for parents problems. Parents 431 (6-12 years) elevated symptoms were randomly assigned to either treatment as usual (TAU), a 6-month WASH intervention (WASH+TAU),...
Abstract Background Pulmonary vein isolation (PVI) is a first-line treatment option for paroxysmal atrial fibrillation (PAF). Radiofrequency ablation (RFA) or Cryoballoon (CBA) are commonly used modalities. Recent studies demonstrated the superiority and potential benefits of very high-power short-duration (vHPSD) RFA using 70 Watts compared to conventional (<50 Watts). Prospective randomized data comparing vHPSD with frequently CBA in setting PAF lacking. Methods We conducted...
IntroductionEmpirical therapy for the treatment of urinary tract infections should be tailored to current distribution and susceptibility potential pathogens ensure optimal treatment.AimWe aimed provide an up-to-date overview epidemiology Enterobacterales isolated from urine in Germany.MethodsWe retrospectively analysed antimicrobial data 201,152 specimens collected between January 2016 June 2021 in- outpatients. Multiple logistic regression analysis was used evaluate association year...
Severe dengue was perceived as one clinical disease entity until the WHO 2009 classification stratified it into severe vascular leakage, bleeding, and organ dysfunction. The objectives of this study were to investigate potential use categories endpoints for intervention research. 271 patients with among 1734 confirmed followed prospectively in hospital-based observational Latin America Asia. We compared distribution according gender age (below/above 15y), determined relative frequency...
Background: Early identification of severe dengue patients is important regarding patient management and resource allocation. We investigated the association 10 biomarkers (VCAM-1, SDC-1, Ang-2, IL-8, IP-10, IL-1RA, sCD163, sTREM-1, ferritin, CRP) with development severe/moderate (S/MD). Methods: performed a nested case-control study from multi-country study. A total 281 S/MD 556 uncomplicated cases were included. Results: On days 1–3 symptom onset, higher levels any biomarker increased risk...
To assess if electronic health record systems in developing countries can improve on timeliness, availability and accuracy of routine reports staff satisfaction after introducing the system, compared to paper-based alternative.The research was conducted with hospital Tororo District Hospital Uganda. A comparative intervention study qualitative quantitative methods used compare (pre-test) system (post-test) focusing accuracy, timeliness monthly about mothers visiting hospital; as outcome...
Abstract Objective Clinical management of dengue relies on careful monitoring fluid balance combined with judicious intravenous ( IV ) therapy. However, in patients significant vascular leakage, fluids may aggravate serosal accumulation and result respiratory distress. Methods Trained physicians followed suspected cases prospectively at seven hospitals across Asia Latin America, using a comprehensive case report form that included daily clinical assessment detailed documentation parenteral...
To compare the performance of two novel recombinant antigens (EgP29, 2B2t) with imaging in a well-defined cohort surgically treated cystic echinococcosis (CE) patients to determine whether serology reflects surgical cure as defined by imaging.From 223 CE-confirmed national clinical center for echinococcosis, 36 were eligible analysis. Sera tested enzyme-linked immunosorbent assay (ELISA) specific IgG and IgG4 antibodies against EgP29 2B2t antigens. We used hierarchical linear regression...
Subcutaneous implantable cardioverter-defibrillators (S-ICDs) have become established in preventing sudden cardiac death, with some advantages over transvenous defibrillator systems, including a lower incidence of lead failures. Despite technological advancements, S-ICD carriers may suffer from significant complications, such as premature battery depletion (PBD), that led to an advisory for nearly 40 000 patients. This multicentre study evaluated the PBD large set
Abstract Background The European Commission (EC) Horizon 2020 (H2020)-funded ZIKAlliance Consortium designed a multicentre study including pregnant women (PW), children (CH) and natural history (NH) cohorts. Clinical sites were selected over wide geographic range within Latin America the Caribbean, taking into account dynamic course of ZIKV epidemic. Methods Recruitment to PW cohort will take place in antenatal care clinics. be enrolled regardless symptoms followed pregnancy, approximately...
Introduction Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is document risks of adverse birth outcomes prevalence laboratory markers congenital deliveries women experiencing ZIKV during pregnancy, using data from European Commission-funded prospective cohort studies 20 centres 11 countries across Latin America Caribbean. Methods analysis We will carry out a centre-by-centre outcomes, comparing confirmed...