A5090812748- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Ethics in Clinical Research
- Vaccine Coverage and Hesitancy
- Viral Infections and Outbreaks Research
- Ethics in medical practice
- Global Maternal and Child Health
- Antibiotic Resistance in Bacteria
- COVID-19 Impact on Reproduction
- Antibiotic Use and Resistance
- Ethics and bioethics in healthcare
- Malaria Research and Control
- Research on Leishmaniasis Studies
- Nosocomial Infections in ICU
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Insect and Pesticide Research
- Zoonotic diseases and public health
- Patient-Provider Communication in Healthcare
- Trypanosoma species research and implications
- Reproductive tract infections research
- Long-Term Effects of COVID-19
- Gastrointestinal motility and disorders
- Intestinal Malrotation and Obstruction Disorders
Industrial University of Santander
2017-2024
World Health Organization
2022
Sanofi (Mexico)
2013
Asociación Colombiana de Facultades de Ingeniería
2013
Centro Internacional de Entrenamiento e Investigaciones Medicas
2004-2012
Universidad El Bosque
2006
Washington University Medical Center
1998-2000
Jewish Hospital
1998
Barnes-Jewish Hospital
1998
In light of the increasing rate dengue infections throughout world despite vector-control measures, several vaccine candidates are in development.In a phase 3 efficacy trial tetravalent five Latin American countries where is endemic, we randomly assigned healthy children between ages 9 and 16 years 2:1 ratio to receive three injections recombinant, live, attenuated, (CYD-TDV) or placebo at months 0, 6, 12 under blinded conditions. The were then followed for 25 months. primary outcome was...
Children have a lower response rate to antimonial drugs and higher elimination of antimony (Sb) than adults. Oral miltefosine has not been evaluated for pediatric cutaneous leishmaniasis.A randomized, noninferiority clinical trial with masked evaluation was conducted at 3 locations in Colombia where Leishmania panamensis guyanensis predominated. One hundred sixteen children aged 2-12 years parasitologically confirmed leishmaniasis were randomized directly observed treatment meglumine...
Background: The dengue virus is a member of the Flavivirus (FV) genus, which also includes yellow fever virus. Dengue disease caused by any 1 4 serotypes and serious public health concern in Latin America. This study evaluated safety immunogenicity candidate recombinant, live-attenuated, tetravalent vaccine (CYD-TDV) 9–16 year olds Methods: In this randomized, blinded, controlled study, volunteers received either 3 doses CYD-TDV (n = 401) or placebo as first second injection...
American cutaneous leishmaniasis (ACL) has been characterized as a zoonotic disease. However, peridomestic and domestic transmission have recorded in at least nine countries Central South America. The present study was undertaken to identify the etiologic agent of epidemic ACL Department Tolima, Colombia. Leishmania isolates were obtained during diagnosis 56 patients with who consulted local control program three municipalities Tolima. Species identified using monoclonal antibodies isoenzyme...
To prepare for a Phase III dengue vaccine efficacy trial, 20 investigational sites were selected this observational study to identify infections in closed cohort ( N = 3,000 children 9–16 years of age). Of 255 acute febrile episodes experienced by 235 children, 50 (21.3%) considered serologically probable dengue, and 18 (7.7%) virologically confirmed (i.e., NS1 antigen positive) cases. Considering the disease-free at-risk period from start onset symptoms, overall incidence density was 17.7...
According to the World Health Organization, 98% of fatal dengue cases can be prevented; however, endemic countries such as Colombia have recorded higher case fatality rates during recent epidemics. We aimed identify predictors mortality that allow risk stratification and timely intervention in patients with dengue. conducted a hospital-based, case-control (1:2) study two areas (2009-2015). Fatal were defined having either 1) positive serological test (IgM or NS1), 2) virological (RT-PCR...
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to cause very high morbidity and mortality throughout Latin American countries. However, few population-based seroprevalence surveys have been conducted quantify attack rates characterize drivers of transmission.Methods: We a cross-sectional study assess the antibodies against SARS-CoV-2 in ten cities Colombia between September December, 2020. The involved multi-stage cluster sampling at each city....
Abstract Background The European Commission (EC) Horizon 2020 (H2020)-funded ZIKAlliance Consortium designed a multicentre study including pregnant women (PW), children (CH) and natural history (NH) cohorts. Clinical sites were selected over wide geographic range within Latin America the Caribbean, taking into account dynamic course of ZIKV epidemic. Methods Recruitment to PW cohort will take place in antenatal care clinics. be enrolled regardless symptoms followed pregnancy, approximately...
To determine the positive predictive value of ocular cytologic specimens and to describe cytopathologic findings encountered in samples from patients with intraocular neoplasms.Intraocular fluids fine needle aspirates (FNAs) cytologically diagnosed as either suspicious or for malignancy during a 15-year period were reviewed, follow-up was obtained.Seventeen (9 vitreous, 6 anterior chamber, 3 FNAs) identified. The mean patient age 58 years (range, 3-91). Cytologic diagnoses included: lymphoma...
Introduction Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is document risks of adverse birth outcomes prevalence laboratory markers congenital deliveries women experiencing ZIKV during pregnancy, using data from European Commission-funded prospective cohort studies 20 centres 11 countries across Latin America Caribbean. Methods analysis We will carry out a centre-by-centre outcomes, comparing confirmed...
Population based serological surveys are the gold-standard to quantify dengue (DENV) transmission. The purpose of this study was estimate age-specific seroprevalence and force infection DENV in an endemic area Colombia. Between July October 2014, we conducted a household cross-sectional survey among 1.037 individuals aged 2 40 years living randomly selected locations urban Piedecuesta, Santander, In addition, also enrolled 246 indviduals rural "veredas". Participants were asked answer...
Introduction. Surveillance systems play a key role in the detection and control of bacterial resistance. It is necessary to constantly collect information from all institutions because mechanisms resistance can operate different ways between countries, cities even hospitals same area. Therefore local important order learnabout behaviour design appropriate interventions for each institution. Between January 2003 December 2004, Centro Internacional de Entrenamiento e Investigaciones Médicas...
A 74-year-old man from the rural area of Caicedonia, Valle del Cauca Province, was diagnosed with uncontrolled hypertension, stage IV chronic renal failure and severe anemia. Fifteen years earlier, while living in Guaviare he leishmaniasis-with lesions located on right upper lower eyelids, left auricle limbs. At that time, received an incomplete treatment antimonials. The patient had experienced 8 progressive mucosal lip, nasal mucosa eyelids (figure 1). histopathological diagnosis...
To assess the sensitivity of vaginal smear cytologic examination in detecting intraepithelial neoplasia (VAIN) and to evaluate findings cases VAIN.Cases with a histologic diagnosis VAIN were identified from Barnes-Jewish Hospital South North Campus over period five nine years, respectively. Only posthysterectomy patients tissue biopsy obtained within three months included study. Pertinent clinical information was by reviewing medical records. Two pathologists reviewed pathologic...
Introduction. Ethics committees are a necessary resource to guarantee ethical integrity in human research; they must apply international standards their evaluation of research projects involving subjects.Objective. The ethics for Colombia were characterized, and recommendations strengthening them formulated.Materials And Methods. In 2003, 280 groups with subjects selected from list which form part the science technology network Colciencias. (Colciencias is Colombian national agency that...
Providing accurate, evidence-based information to women with Zika infection during pregnancy was problematic because of the high degree uncertainty in diagnosis and associated risk. The 2015-17 virus epidemic overwhelmingly affected countries limited access safe abortion. Understanding women's perspectives on risk communication context an emerging pathogen can help inform response future outbreaks that affect fetal or child development. We conducted a cross-sectional qualitative interview...