A5045242784- Mosquito-borne diseases and control
- Viral Infections and Vectors
- HIV/AIDS Research and Interventions
- Hepatitis B Virus Studies
- Tuberculosis Research and Epidemiology
- Global Maternal and Child Health
- HIV-related health complications and treatments
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Public Health in Brazil
- Malaria Research and Control
- Viral gastroenteritis research and epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV Research and Treatment
- Virology and Viral Diseases
- COVID-19 and Mental Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Child Nutrition and Water Access
- HIV/AIDS drug development and treatment
- COVID-19 epidemiological studies
- Parasites and Host Interactions
- Health, Nursing, Elderly Care
- Diagnosis and treatment of tuberculosis
- Healthcare during COVID-19 Pandemic
- Trypanosoma species research and implications
Universidade de Pernambuco
2016-2025
Universidade Federal de Pernambuco
2006-2020
Hospital Universitário Oswaldo Cruz
2009-2020
London School of Hygiene & Tropical Medicine
2020
Centro Universitário Maurício de Nassau
2010-2012
Fundação Oswaldo Cruz
2002-2009
Universidade de Brasília
2009
Universidade Federal de Goiás
2009
This multicentric population-based study in Brazil is the first national effort to estimate prevalence of hepatitis B (HBV) and risk factors capital cities Northeast, Central-West, Federal Districts (2004-2005). Random multistage cluster sampling was used select persons 13-69 years age. Markers for HBV were tested by enzyme-linked immunosorbent assay. The genotypes determined sequencing surface antigen (HBsAg). Multivariate analyses simple catalytic model performed. Overall, 7,881 included;...
Abstract Background Hepatitis C chronic liver disease is a major cause of transplant in developed countries. This article reports the first nationwide population-based survey conducted to estimate seroprevalence HCV antibodies and associated risk factors urban population Brazil. Methods The cross sectional study was all Brazilian macro-regions from 2005 2009, as stratified multistage cluster sample 19,503 inhabitants aged between 10 69 years, representing individuals living 26 State capitals...
Nosocomial pneumonia has correlated to dental plaque and oropharynx colonization in patients receiving mechanical ventilation. The interruption of this process, by preventing pathogenic bacteria, represents a potential procedure for the prevention ventilator-associated (VAP). study design was prospective, randomized trial verify if oral hygiene through toothbrushing plus chlorhexidine gel at 0.12% reduces incidence ventilatior-associated pneumonia, duration ventilation, length hospital stay...
Abstract Background Tuberculosis is still a great challenge to public health in Brazil and worldwide. Early detection followed by effective therapy extremely important controlling the disease. Recent studies have investigated reasons for delays treatment, but there no agreed definition of what constitutes an "acceptable" delay. This study investigates factors associated with total delay treatment tuberculosis. Methods A cohort adult cases pulmonary tuberculosis diagnosed over two-year period...
Background Tuberculosis is known to have socio-economic determinants at individual and area levels, but it not whether they are independent, interact their relative contributions the burden of tuberculosis. Methods A case–control study was conducted in Recife, Brazil, investigate social tuberculosis, explore relationship between two levels calculate contribution It included 1452 cases tuberculosis diagnosed by services 5808 controls selected random from questionnaires completed for...
Background The measurement of CD4+ T-cell (CD4) counts is a strong predictor progression to AIDS and means monitoring antiviral therapy (ART). success or failure controlling virus levels in untreated patients those taking ART may be associated with treatment adherence, habits, correlated infections unrelated HIV, cancer, immunosuppressive drugs; as well socio-economic psychosocial aspects access healthcare. aim the present study was identify, using multilevel model, factors related...
A population-based hepatitis survey was carried out to estimate the prevalence of B virus (HBV) infection and its predictive factors for state capitals from north, south, southeast regions Brazil. multistage cluster sampling used select, successively, census tracts, blocks, households, residents in age group 10–69 years each capital. The surface antigen (HBsAg) lower than 1% southeast, south regions. Socioeconomic condition associated with HBV north Variables related blood route transmission...
Laboratory confirmation of Zika virus (ZIKV) infection during pregnancy is challenging due to cross-reactivity with dengue (DENV) and limited knowledge about the kinetics anti-Zika antibody responses pregnancy. We described ZIKV DENV serological markers maternal-fetal transfer antibodies among mothers neonates after microcephaly outbreak in Northeast Brazil (2016). included 89 cases 173 neonate controls at time birth their mothers. Microcephaly were defined as newborns a particular head...
Congenital viral infections and the occurrence of septo-optic dysplasia, which is a combination optic nerve hypoplasia, abnormal formation structures along midline brain, pituitary hypofunction, support biological plausibility endocrine dysfunction in Zika-related microcephaly. In this case series we ascertained presence describe 30 children with severe microcephaly from MERG Pediatric Cohort, referred for endocrinological evaluation between February August 2019. Of children, 97% had The...
Abstract Objective To estimate the incidence of epilepsy in children with Zika‐related microcephaly first 24 months life; to characterize associated clinical and electrographic findings; summarize treatment responses. Methods We followed a cohort children, born during 2015‐2016 Zika virus (ZIKV) epidemic Brazil, congenital evidence ZIKV infection on neuroimaging and/or laboratory testing. Neurological assessments were performed at ≤3, 6, 12, 15, 18, 21, life. Serial electroencephalograms...
Defining cases of Zika virus (ZIKV) infection is a critical challenge for epidemiological research. Due to ZIKV’s overlapping clinical features and potential immunologic cross-reactivity with other flaviviruses the current lack an optimal ZIKV-specific diagnostic assay, varying approaches identifying ZIKV infections have been employed date. This paper presents laboratory results criteria developed by Microcephaly Epidemic Research Group defining maternal in cohort pregnant women rash (N =...
Knowledge regarding the risks associated with Zika virus (ZIKV) infections in pregnancy has relied on individual studies relatively small sample sizes and variable risk estimates of adverse outcomes, or surveillance routinely collected data. Using data from Brazilian Cohorts Consortium, this study aims, to estimate outcomes among offspring women RT-PCR-confirmed ZIKV infection during explore heterogeneity between studies.We performed an participant meta-analysis 1548 pregnant 13 studies,...
Background The objectives were to estimate the prevalence of hepatitis A among children and adolescents from Northeast Midwest regions Federal District Brazil identify individual-, household- area-levels factors associated with infection. Methods This population-based survey was conducted in 2004–2005 covered individuals aged between 5 19 years. stratified multistage cluster sampling technique probability proportional size used select 1937 years living capital State capitals 12 states study...
Concomitant treatment of Human Immunodeficiency Virus (HIV) infection and tuberculosis (TB) presents a series challenges for compliance both providers patients. We carried out this study to identify risk factors default from TB in people living with HIV. conducted cohort monitor HIV/TB co-infected subjects Pernambuco, Brazil, on monthly basis, until completion or TB. Logistic regression was used calculate crude adjusted odds ratios, 95% confidence intervals P-values. From 2310 HIV subjects,...
To evaluate the effectiveness and safety of polyunsaturated fatty acids for treatment premenstrual syndrome (PMS) using a graded symptom scale to assess effect this on basal plasma levels prolactin total cholesterol. A randomized, double-blind, placebo-controlled study was conducted with 120 women PMS divided into three groups treated 1 or 2 grams medication placebo. Symptoms were recorded over 6-month period Prospective Record Impact Severity Menstruation (PRISM) calendar. Total cholesterol...
The implications of congenital Zika Virus (ZIKV) infections for pediatric neurodevelopment and behavior remain inadequately studied. aim this study is to investigate patterns in groups children with differening severities ZIKV-related microcephaly prenatal ZIKV exposure the absence microcephaly.We conducted a cross-sectional study, nested cohort, 274 (aged 10-45 months) who were born during peak decline epidemic Northeast Brazil. Participants evaluated between February 2017 August 2019 at...
Abstract Background The COVID-19 pandemic had a major impact on the mental health of healthcare workers (HCWs), especially in low and middle-income countries, which to face additional political, social, economic challenges. We thus aimed assess prevalence outcomes associated factors HCWs treating patients one most affected regions Brazil. Methods used Respondent-Driven Sampling method risks infection symptoms disorders nurses, nursing technicians, physicians who worked frontline metropolitan...
Background While Zika virus (ZIKV) is now widely recognized as a teratogen, the frequency and full spectrum of adverse outcomes congenital ZIKV infection remains incompletely understood. Methods Participants in MERG cohort pregnant women with rash, recruited from surveillance system December/2015-June/2017. Exposure definition was based on combination longitudinal data molecular, serologic (IgM IgG3) plaque reduction neutralization tests for ZIKV. Children were evaluated by team clinical...
Objetivo: identificar os fatores que aumentaram o risco de morte em pessoas com coinfecção por tuberculose e COVID-19. Métodos: Este foi um estudo coorte retrospectivo realizado no estado Pernambuco, Brasil. Foram avaliados 10.572 pacientes diagnosticados tuberculose, independentemente contraírem A identificação dos para COVID-19 realizada meio análise bivariada regressão logística multivariada utilizando método stepwise forward. Resultados: a pulmonar mais prevalente 8.833 (83,5%), seguida...
To evaluate the association between metabolic disorders and death in patients receiving Parenteral Nutrition (PN), according to a proposal for stratification into nutri-tional risk groups, using Nutritional Risk Screening, 2002 (NRS-2002). A cohort with 84 PN, an NRS-2002 score of ≥3, classified two subgroups: moderate (NRS 3-4) severe 5-7). Secondary data from medical nutritional records were used. The outcome variable was "presence death"; exposures: risk. Descriptive, bivariate analyses...