A5035773675- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- ECG Monitoring and Analysis
- Electrostatic Discharge in Electronics
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Phonocardiography and Auscultation Techniques
- Cardiovascular Syncope and Autonomic Disorders
- Mobile Health and mHealth Applications
- Neuroscience and Neural Engineering
- Viral Infections and Immunology Research
- Sarcoidosis and Beryllium Toxicity Research
- Cardiomyopathy and Myosin Studies
- Infective Endocarditis Diagnosis and Management
- Pericarditis and Cardiac Tamponade
- Cardiovascular and Diving-Related Complications
- Cardiovascular Effects of Exercise
- Orthopaedic implants and arthroplasty
- Digital Mental Health Interventions
- Cardiovascular and exercise physiology
NIHR Southampton Biomedical Research Centre
2023-2024
University Hospital Southampton NHS Foundation Trust
2015-2024
Cambridge University Hospitals NHS Foundation Trust
2024
University of Southampton
2021-2023
University of Cambridge
2023
Essex Cardiothoracic Centre
2022
Southampton General Hospital
2021-2022
Abstract Background The subcutaneous ICD established its role in the prevention of sudden cardiac death recent years. occurrence premature battery depletion a large subset potentially affected devices has been cause concern. incidence not studied systematically beyond manufacturer-reported data. Methods Retrospective data and most follow-up on S-ICD from fourteen centers Europe, US, Canada was studied. generator removal or failure reported to investigate depletion, defined as within 60...
Subcutaneous implantable cardioverter-defibrillators (S-ICDs) have become established in preventing sudden cardiac death, with some advantages over transvenous defibrillator systems, including a lower incidence of lead failures. Despite technological advancements, S-ICD carriers may suffer from significant complications, such as premature battery depletion (PBD), that led to an advisory for nearly 40 000 patients. This multicentre study evaluated the PBD large set
MICRA implantation is not commonly done as a day-case procedure. Elective leadless pacemakers are implanted routinely in our centre.
Pre-implant ECG screening is performed to ensure that S-ICD recipients have at least one suitable sensing vector, yet cardiac over-sensing remains the commonest cause of inappropriate shock therapy in population. One explanation would be presence dynamic variations morphology result vector eligibility.Adult ICD patients had a 24-h ambulatory using digital Holter positioned record all three vectors. Using an simulator, automated was then one-minute intervals. In vectors with mean score > 100...
Subcutaneous Implantable Cardioverter-Defibrillators (S-ICDs) are used for prevention of sudden cardiac death triggered by ventricular arrhythmias. T Wave Over Sensing (TWOS) is an inherent risk with S-ICDs which can lead to inappropriate shocks. A major predictor TWOS a high T:R ratio (the between the amplitudes and R waves). Currently, patients' Electrocardiograms (ECGs) screened over 10 s measure determine eligibility S-ICD implantation. Due temporal variations in ratio, not long enough...
A 96-year-old woman presented with a 1-day history of pleuritic chest pain 4 days after pacemaker was implanted for complete heart block. Electrocardiography showed
Cardioembolism is an important cause of ischemic stroke, with several studies showing worse outcome than following other stroke subtypes. Paradoxical embolism a rare cardioembolic stroke. We report case patient presumed paradoxical secondary to thrombus formation on the eustachian valve remnant in right atrium. The was anticoagulated resolution mass upon follow-up assessment. diagnostic, investigative and management strategies are discussed for patients suspected causing Physicians reminded...
Abstract Background Patients with an existing subcutaneous implantable cardiac defibrillator (S-ICD) may develop a pacing indication. When transvenous is not feasible, combining S-ICD and leadless pacemaker (LP) can be reasonable option. There are reports of concomitant use both devices. However, the effect on sensing well studied. We hypothesise that changes R T-wave amplitudes, causing in R:T ratios as perceived by S-ICD, increasing risk for T wave oversensing (TWO) during paced rhythm...
Abstract Background A major predictor of eligibility subcutaneous implantable cardiac defibrillators (S-ICD) is the T:R ratio. The cut-off ratio incorporates a safety margin to accommodate for fluctuations ECG signal amplitudes. We introduce deep learning-based tool that accurately measures degree and explore its role in S-ICD screening. Methods Patients were fitted with Holters 24 h record their vectors. Our was used assess over duration recordings. Multiple values applied, identifying...
Machine learning methods are used in the classification of various cardiovascular diseases through ECG data analysis. The concept varying subcutaneous implantable cardiac defibrillator (S-ICD) eligibility, owing to dynamicity signals, has been introduced before. There practical limitations acquiring longer durations signals for S-ICD screening. This study explored potential use deep screening.This was a retrospective study. A tool provide descriptive analysis T:R ratios over 24 h recordings...
Abstract It is standard cardiology practice for patients suffering from ventricular arrhythmias (the main cause of sudden cardiac death) belonging to high risk populations be treated via the implantation Subcutaneous Implantable cardioverter-defibrillators (S-ICDs). S-ICDs carry a so-called T wave over sensing (TWOS), which can lead inappropriate shocks that an inherent health risk. For this reason, according current patients’ Electrocardiograms (ECGs) are manually screened by cardiologist...
S-ICD eligibility is assessed at pre-implant screening where surface ECG traces are used as surrogates for vectors. In heart failure (HF) patients undergoing diuresis, electrolytes and fluid shifts can cause changes in R T waves. Subsequently, T:R ratio, a major predictor of eligibility, be dynamic.This prospective study with structurally normal hearts HF diuresis. All were fitted Holters® to record their Our deep learning model was analyze the ratios across recordings. Welch two sample...
Abstract Background Peri‐procedural complications associated with cardiac implantable electronic devices are not uncommon. European Society of Cardiology guidelines recommend device checks all within 72 h implant. Heart Rhythm Association expert practical guide on Cardiac (CIEDs) that a chest x‐ray (CXR) should be performed 24 to rule out pneumothorax and document lead positions. First, the rate peri‐procedural CIED implants at our center, as well patient and/or procedural‐related factors...
Abstract Introduction Subcutaneous implantable cardioverter–defibrillators (S-ICDs) were introduced to address limitations associated with the transvenous ICDs (TVICDs). The programming features of S-ICDs is however restricted compared TVICDs. Our investigation aims assess outcomes that have been implanted at our institution. Purpose To a tertiary healthcare centre in United Kingdom. Methods A retrospective analysis was conducted, encompassing data from all individuals who underwent S-ICD...
Abstract Introduction Subcutaneous Implantable cardioverter defibrillators (S-ICDs) are now progressively administered as a day-case procedure. While existing data supports the feasibility and safety of same-day discharge after transvenous ICD implantation, comparable evidence for S-ICDs is not well established. This study addresses this by presenting from most extensive population documented in medical literature. We seek to evaluate S-ICD implantation. Purpose To investigate following...
The risk of complications associated with transvenous ICDs make the subcutaneous implantable cardiac defibrillator (S-ICD) a valuable alternative in patients adult congenital heart disease (ACHD). However, higher S-ICD ineligibility and inappropriate shock rates-mostly caused by T wave oversensing (TWO)- are observed this population. We report novel application deep learning methods to screen for eligibility over longer period than conventional screening.
Subcutaneous implantable cardioverter-defibrillators (S-ICDs) offer potentially distinct advantages over transvenous defibrillator systems. Recent randomized trials showed significantly lower lead failure rates than ICD. Still, S-ICDs remain associated with the risk of inappropriate shocks (IAS). While previous studies have reported varying causes IAS, this study explores a rare cause referred to as 'sense-B-noise.' It was recently described in case series, but its incidence has not been...
Haemodialysis patients who require defibrillator therapy are expected to benefit from the entirely avascular subcutaneous (S-ICD), but haemodialysis is associated with dynamic changes in R and T wave amplitude which can impact S-ICD eligibility. A continuous assessment of eligibility during has not previously been performed.Continuous surface ECG recordings were obtained a cohort undergoing maintenance haemodialysis, without an indication for ICD. Automated vector screening was...
Guidelines recommend that cardiac pacing should be considered in patients suffering from frequent vasovagal syncopal (VVS) episodes. Studies have demonstrated the safety and efficacy of leadless pacemakers (LP) cardioinhibitory populations specifically, rendering them a reasonable alternative to transvenous these patients. However, due paucity data on extraction number concomitant LPs can safely implanted, there are concerns regarding LPs' battery longevity, especially younger who may...
Approximately 5.7% of potential subcutaneous implantable cardioverter-defibrillator (S-ICD) recipients are ineligible by virtue their vector morphology, with higher rates ineligibility observed in some at-risk groups. Mathematical rotation is a novel technique that can generate personalized sensing vector, one maximal R:T ratio, using electrocardiogram (ECG) signal recorded from the present S-ICD location.A cohort patients were identified through ECG screening ICD no ventricular pacing...
Abstract Funding Acknowledgements Type of funding sources: Private company. Main source(s): Dr.Mohamed ElRefai is receiving an unrestricted grant from Boston Scientific. Introduction Adult congenital heart disease (ACHD) and hypertrophic cardiomyopathy (HCM) patients who require defibrillator therapy are often relatively young may several generator replacements in their lifetime. The increased risk complications associated with transvenous ICDs make the subcutaneous (S-ICD) a valuable...
Abstract Funding Acknowledgements Type of funding sources: None. Introduction A subset more than 35,000 S-ICD is under FDA advisory, warning the potential premature battery depletion (PBD), caused by a faulty low-voltage capacitor. Based on internal data, manufacturer projects incidence at 3.7% after 5 years. Data independent from sparse. Methods This study was multicenter effort 14 centers in Europe, US, and Canada. Consecutive patients who received participating were included this...