A5067949026- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- ECG Monitoring and Analysis
- Cardiac electrophysiology and arrhythmias
- Malaria Research and Control
- Genomics, phytochemicals, and oxidative stress
- Mosquito-borne diseases and control
- Cardiac Structural Anomalies and Repair
- Neurological disorders and treatments
- Amino Acid Enzymes and Metabolism
- CRISPR and Genetic Engineering
- Polyamine Metabolism and Applications
- Invertebrate Immune Response Mechanisms
- Dark Matter and Cosmic Phenomena
- Cardiac, Anesthesia and Surgical Outcomes
- Glutathione Transferases and Polymorphisms
- Protein Degradation and Inhibitors
- Astrophysics and Cosmic Phenomena
- HIV Research and Treatment
- Sirtuins and Resveratrol in Medicine
- COVID-19 and healthcare impacts
- Political Dynamics in Latin America
- Muscle activation and electromyography studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Universidad del Rosario
2024
Private University of the North
2024
Universidad de Zaragoza
2024
Hospital Universitari i Politècnic La Fe
2014-2023
Temple University
2012-2023
Centro de Investigación en Red en Enfermedades Cardiovasculares
2021-2023
Fluor (United States)
2023
Universitat Politècnica de València
2023
Instituto de Investigación Sanitaria La Fe
2021-2022
Instituto de Investigación Biomédica de Salamanca
2022
To examine fat biopsy samples from lean insulin-sensitive and obese insulin-resistant nondiabetic individuals for evidence of endoplasmic reticulum (ER) stress.Subcutaneous biopsies were obtained the upper thighs six subjects. Fat homogenates used proteomic (two-dimensional gel MALDI-TOF/TOF), Western blot, RT-PCR analysis.Proteomic analysis revealed 19 differentially upregulated proteins in Three these ER stress-related unfolded protein response (UPR) calreticulin, disulfide-isomerase A3,...
Cigarette smoking, which exposes the lung to high concentrations of reactive oxidant species (ROS) is major risk factor for chronic obstructive pulmonary disease (COPD). Recent studies indicate that ROS interfere with protein folding in endoplasmic reticulum and elicit a compensatory response termed "unfolded response" (UPR). The importance UPR lies its ability alter expression variety genes involved antioxidant defense, inflammation, energy metabolism, synthesis, apoptosis, cell cycle...
Shifts in the gene expression of nuclear protein chronic obstructive pulmonary disease (COPD), a progressive that is characterized by extensive lung inflammation and apoptosis, are common; however, extent elevation core histones, which major components proteins their consequences COPD, has not been characterized, important because extracellular histones cytotoxic to endothelial airway epithelial cells.To investigate role COPD progression.We analyzed proteomes ex-smokers with without disease....
Tubulin is a protein that plays critical role in maintaining cellular structure and facilitating cell division. Inhibiting tubulin polymerization has been shown to be an effective strategy for inhibiting the proliferation of cancer cells. In past, identifying compounds could inhibit required use vitro assays utilizing purified or immunofluorescence fixed This study presents novel approach inhibitors using CRISPR-edited line expresses fluorescently tagged β-tubulin nuclear protein, enabling...
Rapid synthesis of the polyamine catabolic enzyme spermidine/spermine-N1-acetyltransferase (SSAT) in response to increased polyamines is an important homeostatic mechanism. Indirect evidence has suggested that there control mechanism involving release a translational repressor protein allows immediate initiation SSAT without RNA transcription, maturation, or translocation. To identify protein, we used mass spectroscopy-based RNA-protein interaction system and found six proteins bind coding...
Hepatic fibrosis is the primary determinant of mortality in patients with metabolic dysfunction–associated steatohepatitis (MASH). Transforming growth factor–β (TGFβ), a master profibrogenic cytokine, promising therapeutic target that has not yet been translated into an effective therapy part because liabilities associated systemic TGFβ antagonism. We have identified soluble folate receptor γ (FOLR3), which expressed humans but rodents, secreted protein elevated livers MASH those steatotic...
Hypothetical axions provide a compelling explanation for dark matter and could be emitted from the hot solar interior. The CERN Axion Solar Telescope has been searching via their back conversion to x-ray photons in 9-T 10-m long magnet directed toward Sun. We report on an extended run with International Observatory pathfinder detector, doubling previous exposure time. detector was operated xenon-based gas mixture part of new run, providing technical insights future configurations. No counts...
Abstract Background The subcutaneous ICD established its role in the prevention of sudden cardiac death recent years. occurrence premature battery depletion a large subset potentially affected devices has been cause concern. incidence not studied systematically beyond manufacturer-reported data. Methods Retrospective data and most follow-up on S-ICD from fourteen centers Europe, US, Canada was studied. generator removal or failure reported to investigate depletion, defined as within 60...