A5056933637- Obesity, Physical Activity, Diet
- Physical Activity and Health
- Behavioral Health and Interventions
- Cognitive Abilities and Testing
- Schizophrenia research and treatment
- Genetic Associations and Epidemiology
- Genetics and Physical Performance
- Children's Physical and Motor Development
- Physical Education and Training Studies
- Child and Adolescent Psychosocial and Emotional Development
- Motivation and Self-Concept in Sports
- Child Development and Digital Technology
- Advanced Neuroimaging Techniques and Applications
- Nutrition, Genetics, and Disease
- Attention Deficit Hyperactivity Disorder
- Functional Brain Connectivity Studies
- Genetic Mapping and Diversity in Plants and Animals
- Eating Disorders and Behaviors
- Balance, Gait, and Falls Prevention
- Obsessive-Compulsive Spectrum Disorders
- Heart Rate Variability and Autonomic Control
- Myofascial pain diagnosis and treatment
- Sleep and related disorders
- Digital Mental Health Interventions
- Non-Invasive Vital Sign Monitoring
RWTH Aachen University
2020-2024
Vrije Universiteit Amsterdam
2012-2020
Amsterdam University Medical Centers
2020
Amsterdam UMC Location Vrije Universiteit Amsterdam
2016-2017
Amsterdam Public Health
2012-2017
Museo Galileo
2015
University Medical Center
2012
The Netherlands Twin Register (NTR) began in 1987 with data collection twins and their families, including families newborn triplets. Twenty-five years later, the NTR has collected at least one survey for 70,784 children, born after 1985. For majority of twins, longitudinal been done by age-specific surveys. Shortly giving birth, mothers receive a first items on pregnancy birth. At age 2, growth achievement milestones is sent. ages 3, 7, 9/10, 12 parents teachers series surveys that are...
Abstract Over the past decades, Internet use has grown substantially, and it now serves people as a supportive tool that is used regularly and—in large parts of world—inevitably. Some develop problematic use, which may lead to addictive behavior becoming important explore risk factors for compulsive use. Data were analyzed on [with Compulsive Use Scale ( CIUS )] from 5247 monozygotic MZ ) dizygotic DZ adolescent twins registered with N etherlands T win R egister. The participants form sample...
Introduction The aim of this study was to investigate the relative influence genetic and environmental factors on children's leisure time exercise behavior through classic twin design. Methods Data were taken from Netherlands Twin Register. twins 7 (n = 3966 subjects), 10 3562), 12-yr-olds 8687), with longitudinal data for 27% sample. Parents asked indicate regular participation in activities, including frequency duration. Resemblance between monozygotic dizygotic weekly MET-hours spent...
Current treatment methods do not achieve recovery for most individuals with schizophrenia, and symptoms such as negative cognitive deficits often persist. Aerobic endurance training has been suggested a potential add-on targeting both physical mental health. We performed large-scale multicenter, rater-blind, parallel-group randomized controlled clinical trial in stable schizophrenia. Participants underwent professionally supervised six-month comprising either aerobic (AET) or flexibility,...
Exercise behavior during leisure time is a major source of health-promoting physical activity and moderately tracks across childhood adolescence. This study aims to investigate the absolute relative contribution genes environment variance in exercise from age 7 18, elucidate stability change genetic shared environmental factors that underlie this behavior. The Netherlands Twin Register collected data on twins aged approximately 7, 10, 12, 14, 16 18 years (N = 27,332 twins; 48 % males; 47...
Twin studies have estimated the relative contribution of genes and environment to variance in exercise behavior it is known that parental education positively affects levels. This study investigates role as a potential modifier from age 7 18 years. The based on large datasets Netherlands Register ( NTR : N = 24 874 twins; surveys around ages 7, 10, 12, 14, 16 years) two Finnish twin cohorts FinnTwin12 4399; 14 17 years; FinnTwin16 4648; 16, years). Regular participation moderate‐to‐vigorous...
Prior searches for genetic variants (GVs) implicated in initiation of cannabis use have been limited to common single nucleotide polymorphisms (SNPs) typed HapMap samples. Denser SNPs are now available with the completion 1000 Genomes and Genome Netherlands projects. More densely distributed expected track causal better. Therefore we extend search early stages previously untagged low-frequency variants. We run heritability, SNP gene-based analyses age at onset. This is first genome-wide...
Whereas short and problematic sleep are associated with psychological problems in adolescence, causality remains to be elucidated. This study therefore utilized the discordant monozygotic cotwin design cross-lagged models investigate how affect functioning.Adolescent twins (N = 12,803, 13-20 years, 42% male) completed questionnaires on functioning repeatedly over a two-year interval. Monozygotic twin pairs were classified as concordant or for duration trouble sleeping. Resulting subgroups...
Twin studies provide evidence that genetic influences contribute strongly to individual differences in exercise behavior. We hypothesize part of this heritability is explained by variation the dopaminergic reward system. Eight single nucleotide polymorphisms (SNPs DRD1: rs265981, DRD2: rs6275, rs1800497, DRD3: rs6280, DRD4: rs1800955, DBH: rs1611115, rs2519152, and COMT: rs4680) three variable number tandem repeats (VNTRs DRD4, upstream DRD5, DAT1) were investigated for an association with...
Abstract Exercise interventions are nowadays considered as effective add-on treatments in people with schizophrenia but usually associated high dropout rates. Therefore, the present study investigated potential predictors of adherence from a large multicenter study, encompassing two types exercise training, conducted over 6-month period individuals schizophrenia. First, we examined role multiple participants’ characteristics, including levels functioning, symptom severity, cognitive...
Objective A higher prevalence of obesity in lower socioeconomic classes is common Western societies. This study examined the role gene–environment interactions association between parental education and body mass index (BMI) from infancy to onset adulthood. Methods Parentally reported BMI 1 13 self‐reported 14 20 years age were collected 16,646 complete Dutch twin pairs analyzed by genetic modeling. Results At 7 8 age, children whose parents had middle or low educational levels more excess...
The aim of this study was to estimate the contribution genetic and environmental influences on motives for engaging in leisure‐time physical activity. participants were obtained from FinnTwin16 study. A modified version Recreational Exercise Motivation Measure used assess activity 2542 twin individuals (mean age 34.1 years). Linear structural equation modeling investigate motive dimensions. highest heritability estimates found dimensions “enjoyment” [men 33% (95% CI 23–43%), women 53%...
Understanding the sources of large individual differences in sedentary behavior is great importance as this associated with pre-mature mortality and non-communicable diseases. Here, we report on contribution genetic environmental factors to variation objectively assessed (accelerometer) self-reported sitting their shared basis. In addition, overlap risk influencing time moderate-to-vigorous physical activity (MVPA) was estimated. A sample 800 individuals (twins siblings) equipped an...
This population-based study aimed (1) to test the presence of an association between regular voluntary exercise behaviour (EB) that is performed in leisure time and body mass index (BMI) youth (2) investigate causal nature this using a longitudinal design genetically informative subjects.Both EB BMI were assessed repeatedly over 21 458 twin individuals from Netherlands Twin Register (47.5% male) - first by parental report (ages 7, 10 12) subsequently through self-report surveys 14, 16 18)....
Abstract Evidence for the effectiveness of physical activity (PA) in treatment depression prevails outpatients with mild and moderate symptom levels. For inpatient severe depression, evidence-based exists only structured supervised group PA interventions. The Step Away from Depression (SAD) study investigated an individual pedometer intervention (PI) combined diary added to as usual (TAU). In this multicenter randomized controlled trial, 192 patients were TAU or plus PI. two primary outcomes...
Aerobic exercise interventions in people with schizophrenia have been demonstrated to improve clinical outcomes, but findings regarding the underlying neural mechanisms are limited and mainly focus on hippocampal formation. Therefore, we conducted a global exploratory analysis of structural functional adaptations after explored their implications.
Abstract Background Depression in old age is associated with an increased fall risk. Especially cognitively challenging situations, fall-promoting gait deviations could appear due to depression- and age-related cognitive deficits. Aim This study investigates (i) whether there are differences performance between depressed older patients healthy controls (ii) if patterns aggravate when performing a task whilst walking. Methods 16 (mean age: 73.1 ± 5.8 years) 19 73.3 6.1 were included the...