A5044535404- Gut microbiota and health
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Neutropenia and Cancer Infections
- Nutritional Studies and Diet
- Coral and Marine Ecosystems Studies
- Methane Hydrates and Related Phenomena
- Mycobacterium research and diagnosis
- Microbial Community Ecology and Physiology
- Colorectal Cancer Screening and Detection
- Dietary Effects on Health
- Pancreatic and Hepatic Oncology Research
- Muscle metabolism and nutrition
- Plant and fungal interactions
- Atmospheric and Environmental Gas Dynamics
- Respiratory viral infections research
- Intestinal and Peritoneal Adhesions
- Urinary Tract Infections Management
- Phytoestrogen effects and research
- Environmental Impact and Sustainability
- Fermentation and Sensory Analysis
- Life Cycle Costing Analysis
- Eating Disorders and Behaviors
- Cancer survivorship and care
- Food composition and properties
University of Bologna
2019-2024
Marche Polytechnic University
2022
Jackson and Tull (United States)
2021
Abstract The correlation existing between gut microbiota diversity and survival after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has so far been studied in adults. Pediatric studies question whether this association applies to children as well. Stool samples from a multicenter cohort of 90 pediatric allo-HSCT recipients were analyzed using 16S ribosomal RNA amplicon sequencing profile the estimate with Shannon index. A global-to-local networking approach was used...
Wines produced from the same grape cultivars but in different locations possess distinctive qualities leading to consumer's appreciation, preferences, and thus purchase choices. Here, we explore possible importance of microbiomes at soil-plant interface as a determinant terroir properties grapevine production, which confer specific growth performances wine chemo-sensory local scale.In particular, investigated variation microbial communities associated with roots Vitis vinifera cultivar...
Epithelial ovarian cancer (EOC) is one of the most lethal and silent gynecological tumors. Despite appropriate surgery chemotherapy, relapse occurs in over half patients with a poor prognosis. Recently, gut microbiota (GM) was hypothesized to influence efficacy anticancer therapies, but no data are available EOC. Here, by 16S rRNA gene sequencing inferred metagenomics, we profiled GM EOC at diagnosis reconstructed its trajectory along course neoadjuvant or adjuvant chemotherapy up follow-up....
Despite the recent breakthroughs in targeted and immunotherapy for melanoma, overall survival rate remains low. In years, considerable attention has been paid to gut microbiota other modifiable patient factors (e.g., diet body composition), though their role influencing therapeutic responses yet be defined. Here, we characterized a cohort of 31 patients with unresectable IIIC-IV-stage cutaneous melanoma prior initiation or first-line via following methods: (i) fecal microbiome metabolome 16S...
Abstract The gut microbiome (GM) has shown to influence hematopoietic stem cell transplantation (HSCT) outcome. Evidence on levofloxacin (LVX) prophylaxis usefulness before HSCT in pediatric patients is controversial and its impact GM poorly characterized. Post-HSCT parenteral nutrition (PN) oftentimes the first-line nutritional support neutropenic phase, despite emerging benefits of enteral (EN). In this exploratory work, we used a global-to-local networking approach obtain high-resolution...
Background and AimsTo investigate gut microbiome (GM) dynamics in relation to carbapenem-resistant Enterobacterales (CRE) colonization, CRE infection non-CRE development within 2 months after liver transplant (LT).MethodsA single-center, prospective study was performed patients undergoing LT from November 2018 January 2020. GM profiled by 16S rRNA amplicon sequencing of rectal swab taken on the day transplantation fecal samples collected weekly until 1 month LT. A subset subjected shotgun...
Introduction The impact of diet on mental well-being and gut microorganisms in humans is well recognized. However, research the connections between food nutrients, microbiota, health remains limited. To address this, present study aimed to assess effects a personalized diet, based individual needs aligned with Mediterranean principles, depression symptoms, quality life, nutritional intake, microbiota changes among older adults living community. Methods intervention involved regular visits...
Several studies reported alterations of the human gut microbiota (GM) during COVID-19. To evaluate potential role GM as an early predictor COVID-19 at disease onset, we analyzed microbial samples 315 patients that differed in severity. We observed significant variations diversity and composition associated with increasing severity, reduction short-chain fatty acid producers such
Abstract Because of their recognized global importance, there is now the urgent need to map diversity and distribution patterns marine microbial communities. Even if available studies provided some advances in understanding biogeographical microbiomes at scale, degree plasticity local scale it still underexplored, functional implications be dissected. In this scenario here we provide a synoptical study on water column surface sediments from 19 sites 130 km 2 area located 13.5 afar coast...
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Abstract Background The prophylactic use of quinolones in the setting allogeneic hematopoietic stem cell transplantation (allo-HCT) is controversial and solid evidence missing, particularly children. Methods In this single-center retrospective study, we compared outcomes patients receiving (n = 74) or not 70) levofloxacin (LVX) prophylaxis, assessing overall survival, event-free acute graft-versus-host disease (aGvHD) bloodstream infection incidence, infection-related mortality. Gut...
Deep learning methodologies have revolutionized prediction in many fields and show the potential to do same microbial metagenomics. However, deep is still unexplored field of microbiology, with only a few software designed work microbiome data. Within meta-community theory, we foresee new perspectives for development application algorithms human microbiome. In this context, developed G2S, bioinformatic tool taxonomic fecal directly from oral data individual. The uses convolutional neural...
Background Vitamin D (Vit D) deficiency (VDD), associated with diverse health conditions, is commonly treated Vit D3 supplements. However, the gastrointestinal (GI) absorption of in different formulations has not been well studied. Objective We aimed to compare an innovative phospholipids-sucrester matrix biodelivery vehicle-based (sucrosomial ® ) orodispersible preparation against a reference chewable tablet and soft gel capsule (SGC) D-deficient healthy adults. Methods In study 1, 25...
Introduction Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis and hospitalization in infants worldwide. The nasopharyngeal microbiota has been suggested to play a role influencing clinical course RSV bronchiolitis, some evidence provided regarding oral gut microbiota. However, studies have focused on single timepoint, none investigated all three ecosystems at once. Methods Here, we simultaneously reconstructed gut, dynamics 19 with relation duration (more or less...
Faecalibacterium prausnitzii is one of the most prevalent and abundant polyphyletic health-promoting components human gut microbiome with a propensity for dysbiotic decreases. To better understand its biology in gut, we specifically explored divergence pressures acting on F. clades global scale. Five were de novo identified from 55 publicly available genomes 92 high-quality metagenome assembled genomes. Divergence rate indices constructed validated to compare rates among different between...