A5040388807- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Salmonella and Campylobacter epidemiology
- Travel-related health issues
- Global Maternal and Child Health
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Burkholderia infections and melioidosis
- HIV Research and Treatment
- Bacterial Identification and Susceptibility Testing
- Clostridium difficile and Clostridium perfringens research
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- COVID-19 and healthcare impacts
- Patient Satisfaction in Healthcare
- Malaria Research and Control
- Vibrio bacteria research studies
- Viral Infections and Outbreaks Research
- Tuberculosis Research and Epidemiology
- Parasites and Host Interactions
- Pharmaceutical Practices and Patient Outcomes
- Infections and bacterial resistance
Antwerp University Hospital
2016-2025
University of Antwerp
2008-2024
Instituut voor Tropische Geneeskunde
2011-2022
Hospital for Tropical Diseases
2012-2019
FOD Volksgezondheid, Veiligheid van de Voedselketen en Leefmilieu
2015
Research Institute for Tropical Medicine
2010
There are different patterns in the COVID-19 outbreak general population and amongst nursing home patients. We investigate time from symptom onset to diagnosis hospitalization or length of stay (LoS) hospital, whether there differences population. Sciensano collected information on 14,618 hospitalized patients with admissions 114 Belgian hospitals between 14 March 12 June 2020. The distributions event times for patient groups estimated accounting interval censoring right truncation...
The WHO Access, Watch and Reserve (AWaRe) classification has been developed to support countries hospitals in promoting rational use of antibiotics while improving access these essential medicines. We aimed describe patterns worldwide antibiotic according the AWaRe adult inpatient population.The Global Point Prevalence Survey on Antimicrobial Consumption Resistance (Global-PPS) collects hospital data using a standardized PPS methodology. Global-PPS 2015, 2017 2018 data, collected by 664 69...
Abstract In contrast to the many reports of successful real-world cases personalized bacteriophage therapy (BT), randomized controlled trials non-personalized products have not produced expected results. Here we present outcomes a retrospective observational analysis first 100 consecutive BT difficult-to-treat infections facilitated by Belgian consortium in 35 hospitals, 29 cities and 12 countries during period from 1 January 2008 30 April 2022. We assessed how often positive clinical...
In an effort to raise protective antiviral immunity, dendritic cell immunotherapy was evaluated in six adults infected with human immunodeficiency virus (HIV)-1 and stable under highly active antiretroviral therapy (HAART).Autologous monocyte-derived cells electroporated mRNA encoding Gag a chimeric Tat-Rev-Nef protein were administered, whereas patients remained on HAART. Feasibility, safety, immunogenicity responses investigated.Dendritic vaccine preparation administration successful all...
Clostridioides difficile infection (CDI) is a common healthcare-associated and leading cause of gastroenteritis-related mortality worldwide. However, data on CDI-associated are scarce. We aimed to examine the association between CDI all-cause cause-specific mortality. additionally explored contributing causes mortality, including recurrent CDI, hospital- or community-acquired chronic comorbidities, age.
Background Salmonella enterica is a frequent cause of bloodstream infection (BSI) in Asia but few data are available from Cambodia. We describe BSI isolates recovered patients presenting at Sihanouk Hospital Centre Hope, Phnom Penh, Cambodia (July 2007–December 2010). Methodology Blood was cultured as part microbiological prospective surveillance study. Identification performed by conventional methods and serotyping. Antibiotic susceptibilities were assessed using disk diffusion, MicroScan...
To assess the antibiotic prescribing practices of doctors working in Lao People's Democratic Republic and their knowledge local resistance patterns.Doctors attending morning meetings 25 public hospitals four provinces were asked to complete a knowledge, attitude practice survey. The questionnaire contained 43 multiple choice questions that doctor answered at time meeting.The response rate was 83.4% (386/463). Two hundred seventy (59.8%) declared they had insufficient information about...
Cambodia is affected by antibiotic resistance but interventions to reduce the level of require knowledge phenomena that lead inappropriate prescribing. We interviewed physicians working in public hospitals explore drivers prescribing.Hospitals participating a knowledge, attitudes and practices survey prior this study were purposively selected randomly recruited participate focus group discussions. Nvivo version 10 was used inductively code qualitative transcripts manage thematic data...
Background Bloodstream infections (BSI) cause important morbidity and mortality worldwide. In Cambodia, no surveillance data on BSI are available so far. Methods From all adults presenting with SIRS at Sihanouk Hospital Centre of HOPE (July 2007–December 2010), 20 ml blood was cultured. Isolates were identified using standard microbiological techniques; antibiotic susceptibilities assessed disk diffusion MicroScan®, additional E-test, D-test double test where applicable, according to CLSI...
Abstract Background The Global Point Prevalence Survey of Antimicrobial Consumption and Resistance (Global-PPS) provides a methodology to support hospitals worldwide in collecting antimicrobial use data. We aim evaluate the impact Global-PPS on local stewardship (AMS) programmes assess health care professionals’ educational needs barriers for implementing AMS. Methods A cross-sectional survey was disseminated within network. target audience consisted hospital healthcare workers, involved...
Abstract Background Antibiotics and proton pump inhibitors (PPI) are recognized risk factors for acquisition recurrence of Clostridioides difficile infection (CDI), yet combined effects remain unclear. Objectives To assess the short- long-term antibiotics PPIs on CDI recurrence. Methods Population-based study including all 43 152 patients diagnosed with in Sweden (2006–2019), 355 172 matched population controls without CDI. The impact was explored recent (0–30 days) preceding (31–180 use...
This study investigates the screening practices for congenital cytomegalovirus (cCMV) in Flanders, Belgium, with aim of determining frequency neonatal and number diagnoses resulting from it. Flemish hospitals maternity facilities were asked data on infants screened cCMV (PCR-CMV saliva or urine), diagnosed (positive PCR-CMV urine before age 3 weeks). Screening diagnosis rates compared across geographic regions policies. We defined that at least 3% neonates should be screened, given...
Abstract Background Hospitals in low- and middle-income countries (LMIC) face context-specific challenges implementing antimicrobial stewardship (AMS) programmes. The Global Point Prevalence Survey (Global-PPS) project has established a network of hospitals across 90 countries, using point prevalence surveys to monitor use guide AMS activities. However, little is known about implementation these hospitals. Using qualitative research, we aim explore the process LMIC within Global-PPS factors...
Colistin is used as last treatment option for pneumonia associated with multidrug-resistant (MDR) Pseudomonas spp.. Literature about the best administration mode (inhalation versus parenteral treatment) lacking.A retrospective study of 20 intensive care patients a MDR P. aeruginosa receiving colistin sulphomethate sodium (Colistineb®) between 2007 and 2009 was performed. A strain considered if it resistant to at least 6 following antibiotics: piperacillin-tazobactam, ceftazidime, cefepime,...
The alarming global rise of antimicrobial resistance combined with the lack new agents has led to a renewed interest in optimization our current antibiotics. Continuous infusion (CI) time-dependent antibiotics certain theoretical advantages toward efficacy based on pharmacokinetic/pharmacodynamic principles. We reviewed available clinical studies concerning continuous beta-lactam and vancomycin critically ill patients. conclude that CI is not necessarily more advantageous for all only likely...
Campylobacter infection is a common cause of diarrhea among international travelers. We studied antibiotic resistance patterns isolates obtained from travelers according to travel destination. Three collections between 2007 and 2014 (Institute Tropical Medicine, the "Laboratoire Hospitalier Universitaire de Bruxelles "and Belgian National Reference Centre for Campylobacter) were used. Isolates tested minimal inhibitory concentration (MIC) values (E-test macromethod) fluoroquinolones,...
Background Enteric fever remains a major public health problem in low resource settings and antibiotic resistance is increasing. In Asia, an increasing proportion of infections caused by Salmonella enterica serovar Paratyphi A, which for long time was assumed to cause milder clinical syndrome compared Typhi. Methodology A retrospective chart review study conducted 254 unique cases blood culture confirmed enteric who presented at referral adult hospital Phnom Penh, Cambodia between 2008 2015....
Antibiotic misuse is widespread in resource-limited countries such as Cambodia where the burden of infectious diseases high and access to antibiotics unrestricted. We explored healthcare seeking behaviour related obtaining drivers antibiotic Cambodian community. In-depth interviews were held with family members patients being admitted hospitals private pharmacies termed pharmacy attendants catchment areas hospitals. Nurses who run community primary centres located within hospital invited...