A5029481092- Bacteriophages and microbial interactions
- Antifungal resistance and susceptibility
- Bacterial biofilms and quorum sensing
- Microbial infections and disease research
- Genomics and Phylogenetic Studies
- Monoclonal and Polyclonal Antibodies Research
- Oral microbiology and periodontitis research
- Salmonella and Campylobacter epidemiology
- Fungal Infections and Studies
- Plant Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Ocular Surface and Contact Lens
- Probiotics and Fermented Foods
- Microbial Community Ecology and Physiology
- Vibrio bacteria research studies
- Listeria monocytogenes in Food Safety
- Protein purification and stability
- Viral Infectious Diseases and Gene Expression in Insects
- Bacterial Genetics and Biotechnology
- Biosensors and Analytical Detection
- Antibiotic Resistance in Bacteria
- Antimicrobial Peptides and Activities
- Antimicrobial Resistance in Staphylococcus
- Medical and Biological Ozone Research
- RNA and protein synthesis mechanisms
University of Minho
2016-2025
Administração Regional de Saúde de Lisboa e Vale do Tejo
2024-2025
Universidade Nova de Lisboa
2025
Institute of Mechanical Engineering and Industrial Mangement
2023-2024
Nova Medical (United States)
2024
European Society of Clinical Microbiology and Infectious Diseases
2023
ORCID
2021
Institute for Biotechnology and Bioengineering
2007-2020
Universidade do Porto
2016
Gheorghe Asachi Technical University of Iași
2010
Most cases of candidiasis have been attributed to C. albicans, but recently, non- Candida albicans (NCAC) species identified as common pathogens. The ability form biofilms has important clinical repercussions due their increased resistance antifungal therapy and the yeast cells within withstand host immune defenses. Given this importance biofilm growth form, aim study was characterize produced by three NCAC species, namely parapsilosis, tropicalis glabrata. forming isolates glabrata...
The global threat to public health posed by emerging multidrug-resistant bacteria in the past few years necessitates development of novel approaches combat bacterial infections. Endolysins encoded viruses (or phages) represent one promising avenue investigation. These enzyme-based antibacterials efficiently kill Gram-positive upon contact specific cell wall hydrolysis. However, a major hurdle their exploitation as against Gram-negative pathogens is impermeable lipopolysaccharide layer...
The interest for natural antimicrobial compounds has increased due to alterations in consumer positions towards the use of chemical preservatives foodstuff and food processing surfaces. Bacteriophages fit class their effectiveness controlling bacterial pathogens agro-food industry led development different phage products already approved by USFDA USDA. majority these are be used farm animals or animal such as carcasses, meats also agricultural horticultural products. Treatment with specific...
Biofilm formation occurs spontaneously on both inert and living systems is an important bacterial survival strategy. In humans bioflms are responsible for many pathologies, most of them associated with the use medical devices. A major problem biofilms their inherent tolerance to host defences antibiotic therapies; there therefore urgent need develop alternative ways prevent control biofilm-associated clinical infections. Several in vitro experiments have shown that phages able infect biofilm...
Phages are recognized as the most abundant and diverse entities on planet. Their diversity is determined predominantly by their dynamic adaptation capacities when confronted with different selective pressures in an endless cycle of coevolution a widespread group bacterial hosts. At end infection cycle, progeny virions rigid cell wall that hinders release into environment opportunity to start new cycle. Consequently, phages encode hydrolytic enzymes, called endolysins, digest peptidoglycan....
Abstract In contrast to the many reports of successful real-world cases personalized bacteriophage therapy (BT), randomized controlled trials non-personalized products have not produced expected results. Here we present outcomes a retrospective observational analysis first 100 consecutive BT difficult-to-treat infections facilitated by Belgian consortium in 35 hospitals, 29 cities and 12 countries during period from 1 January 2008 30 April 2022. We assessed how often positive clinical...
Objectives: To quantitatively compare the antibiotic susceptibility of biofilms formed by coagulase-negative staphylococci (CoNS) Staphylococcus epidermidis and haemolyticus with planktonic cultures.
Abstract Background Poultry meat is one of the most important sources human campylobacteriosis, an acute bacterial enteritis which a major problem worldwide. Campylobacter coli and jejuni are common species associated with this disease. These pathogens live in intestinal tract avian under commercial conditions they spread rapidly to infect high proportion flock, makes their treatment prevention very difficult. Bacteriophages (phages) naturally occurring predators bacteria specificity also...
ABSTRACT Staphylococcus epidermidis is an important cause of nosocomial infections. Virulence attributable to elaboration biofilms on medical surfaces that protect the organisms from immune system clearance. Even though leukocytes can penetrate biofilms, they fail phagocytose and kill bacteria. The properties make biofilm bacteria resistant are not well characterized. In order better understand mechanisms resistance in system, we evaluated antibody penetration throughout antibody-mediated...
Resistance rates are increasing among several problematic Gram-negative pathogens, a fact that has encouraged the development of new antimicrobial agents. This paper characterizes Salmonella phage endolysin (Lys68) and demonstrates its potential effectiveness when combined with organic acids towards pathogens. Biochemical characterization reveals Lys68 is more active at pH 7.0, maintaining 76.7% activity stored 4°C for two months. Thermostability tests showed only completely inactivated upon...